Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
dc.contributor.author | Bonsignori, Mattia | |
dc.contributor.author | Montefiori, David C | |
dc.contributor.author | Wu, Xueling | |
dc.contributor.author | Chen, Xi | |
dc.contributor.author | Hwang, Kwan-Ki | |
dc.contributor.author | Tsao, Chun-Yen | |
dc.contributor.author | Kozink, Daniel M | |
dc.contributor.author | Parks, Robert J | |
dc.contributor.author | Tomaras, Georgia D | |
dc.contributor.author | Crump, John A | |
dc.contributor.author | Kapiga, Saidi H | |
dc.contributor.author | Sam, Noel E | |
dc.contributor.author | Kwong, Peter D | |
dc.contributor.author | Kepler, Thomas B | |
dc.contributor.author | Liao, Hua-Xin | |
dc.contributor.author | Mascola, John R | |
dc.contributor.author | Haynes, Barton F | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2017-03-02T19:17:35Z | |
dc.date.available | 2017-03-02T19:17:35Z | |
dc.date.issued | 2012-04 | |
dc.description.abstract | Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities. | |
dc.identifier | ||
dc.identifier | JVI.07163-11 | |
dc.identifier.eissn | 1098-5514 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | American Society for Microbiology | |
dc.relation.ispartof | J Virol | |
dc.relation.isversionof | 10.1128/JVI.07163-11 | |
dc.subject | AIDS Vaccines | |
dc.subject | Antibodies, Neutralizing | |
dc.subject | Antibody Specificity | |
dc.subject | Antigens, CD4 | |
dc.subject | B-Lymphocytes | |
dc.subject | Binding Sites | |
dc.subject | Epitopes | |
dc.subject | HIV Antibodies | |
dc.subject | HIV Envelope Protein gp120 | |
dc.subject | HIV Infections | |
dc.subject | HIV-1 | |
dc.subject | Humans | |
dc.subject | Immunoglobulin Variable Region | |
dc.subject | Neutralization Tests | |
dc.subject | Phylogeny | |
dc.title | Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. | |
dc.type | Journal article | |
duke.contributor.orcid | Bonsignori, Mattia|0000-0003-2973-2101 | |
duke.contributor.orcid | Montefiori, David C|0000-0003-0856-6319 | |
duke.contributor.orcid | Tomaras, Georgia D|0000-0001-8076-1931 | |
duke.contributor.orcid | Crump, John A|0000-0002-4529-102X | |
pubs.author-url | ||
pubs.begin-page | 4688 | |
pubs.end-page | 4692 | |
pubs.issue | 8 | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Human Vaccine Institute | |
pubs.organisational-group | Global Health Institute | |
pubs.organisational-group | Immunology | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Duke Human Vaccine Institute | |
pubs.organisational-group | Medicine, Infectious Diseases | |
pubs.organisational-group | Molecular Genetics and Microbiology | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Surgery | |
pubs.organisational-group | Surgery, Surgical Sciences | |
pubs.organisational-group | Surgery, Surgical Sciences Section for AIDS Research & Development | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 86 |
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