Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.

dc.contributor.author

Bonsignori, Mattia

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Montefiori, David C

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Wu, Xueling

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Chen, Xi

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Hwang, Kwan-Ki

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Tsao, Chun-Yen

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Kozink, Daniel M

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Parks, Robert J

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Tomaras, Georgia D

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Crump, John A

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Kapiga, Saidi H

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Sam, Noel E

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Kwong, Peter D

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Kepler, Thomas B

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Liao, Hua-Xin

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Mascola, John R

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Haynes, Barton F

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United States

dc.date.accessioned

2017-03-02T19:17:35Z

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2017-03-02T19:17:35Z

dc.date.issued

2012-04

dc.description.abstract

Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/22301150

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JVI.07163-11

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1098-5514

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https://hdl.handle.net/10161/13785

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eng

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American Society for Microbiology

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J Virol

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10.1128/JVI.07163-11

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AIDS Vaccines

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Antibodies, Neutralizing

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Antibody Specificity

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Antigens, CD4

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B-Lymphocytes

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Binding Sites

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Epitopes

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HIV Antibodies

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HIV Envelope Protein gp120

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HIV Infections

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HIV-1

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Humans

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Immunoglobulin Variable Region

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Neutralization Tests

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Phylogeny

dc.title

Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.

dc.type

Journal article

duke.contributor.orcid

Bonsignori, Mattia|0000-0003-2973-2101

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Montefiori, David C|0000-0003-0856-6319

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Tomaras, Georgia D|0000-0001-8076-1931

duke.contributor.orcid

Crump, John A|0000-0002-4529-102X

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/22301150

pubs.begin-page

4688

pubs.end-page

4692

pubs.issue

8

pubs.organisational-group

Basic Science Departments

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Clinical Science Departments

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Duke

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Duke Cancer Institute

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Duke Human Vaccine Institute

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Global Health Institute

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Immunology

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Institutes and Centers

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Institutes and Provost's Academic Units

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Medicine

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Medicine, Duke Human Vaccine Institute

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Medicine, Infectious Diseases

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Molecular Genetics and Microbiology

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Pathology

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School of Medicine

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Surgery

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Surgery, Surgical Sciences

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Surgery, Surgical Sciences Section for AIDS Research & Development

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University Institutes and Centers

pubs.publication-status

Published

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86

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