Delayed mortality among solid organ transplant recipients hospitalized for COVID-19.
| dc.contributor.author | Heldman, Madeleine R | |
| dc.contributor.author | Kates, Olivia S | |
| dc.contributor.author | Safa, Kassem | |
| dc.contributor.author | Kotton, Camille N | |
| dc.contributor.author | Multani, Ashrit | |
| dc.contributor.author | Georgia, Sarah J | |
| dc.contributor.author | Steinbrink, Julie M | |
| dc.contributor.author | Alexander, Barbara D | |
| dc.contributor.author | Blumberg, Emily A | |
| dc.contributor.author | Haydel, Brandy | |
| dc.contributor.author | Hemmige, Vagish | |
| dc.contributor.author | Hemmersbach-Miller, Marion | |
| dc.contributor.author | La Hoz, Ricardo M | |
| dc.contributor.author | Moni, Lisset | |
| dc.contributor.author | Condor, Yesabeli | |
| dc.contributor.author | Flores, Sandra | |
| dc.contributor.author | Munoz, Carlos G | |
| dc.contributor.author | Guitierrez, Juan | |
| dc.contributor.author | Diaz, Esther I | |
| dc.contributor.author | Diaz, Daniela | |
| dc.contributor.author | Vianna, Rodrigo | |
| dc.contributor.author | Guerra, Giselle | |
| dc.contributor.author | Loebe, Matthias | |
| dc.contributor.author | Yabu, Julie M | |
| dc.contributor.author | Kramer, Kailey Hughes | |
| dc.contributor.author | Tanna, Sajal D | |
| dc.contributor.author | Ison, Michael G | |
| dc.contributor.author | Rakita, Robert M | |
| dc.contributor.author | Malinis, Maricar | |
| dc.contributor.author | Azar, Marwan M | |
| dc.contributor.author | McCort, Margaret E | |
| dc.contributor.author | Singh, Pooja P | |
| dc.contributor.author | Velioglu, Arzu | |
| dc.contributor.author | Mehta, Sapna A | |
| dc.contributor.author | van Duin, David | |
| dc.contributor.author | Goldman, Jason D | |
| dc.contributor.author | Lease, Erika D | |
| dc.contributor.author | Wald, Anna | |
| dc.contributor.author | Limaye, Ajit P | |
| dc.contributor.author | Fisher, Cynthia E | |
| dc.contributor.author | UW Covid-19 SOT Study Team | |
| dc.date.accessioned | 2022-10-03T11:03:32Z | |
| dc.date.available | 2022-10-03T11:03:32Z | |
| dc.date.issued | 2022-02 | |
| dc.date.updated | 2022-10-03T11:03:31Z | |
| dc.description.abstract | IntroductionMost studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month of illness onset. Delayed mortality in SOT recipients hospitalized for COVID-19 has not been fully examined.MethodsWe used data from a multicenter registry to calculate mortality by 90 days following initial SARS-CoV-2 detection in SOT recipients hospitalized for COVID-19 and developed multivariable Cox proportional-hazards models to compare risk factors for death by days 28 and 90.ResultsVital status at day 90 was available for 936 of 1117 (84%) SOT recipients hospitalized for COVID-19: 190 of 936 (20%) died by 28 days and an additional 56 of 246 deaths (23%) occurred between days 29 and 90. Factors associated with mortality by day 90 included: age > 65 years [aHR 1.8 (1.3-2.4), p =<0.001], lung transplant (vs. non-lung transplant) [aHR 1.5 (1.0-2.3), p=0.05], heart failure [aHR 1.9 (1.2-2.9), p=0.006], chronic lung disease [aHR 2.3 (1.5-3.6), p<0.001] and body mass index ≥ 30 kg/m 2 [aHR 1.5 (1.1-2.0), p=0.02]. These associations were similar for mortality by day 28. Compared to diagnosis during early 2020 (March 1-June 19, 2020), diagnosis during late 2020 (June 20-December 31, 2020) was associated with lower mortality by day 28 [aHR 0.7 (0.5-1.0, p=0.04] but not by day 90 [aHR 0.9 (0.7-1.3), p=0.61].ConclusionsIn SOT recipients hospitalized for COVID-19, >20% of deaths occurred between 28 and 90 days following SARS-CoV-2 diagnosis. Future investigations should consider extending follow-up duration to 90 days for more complete mortality assessment. | |
| dc.identifier | 6536752 | |
| dc.identifier.issn | 1058-4838 | |
| dc.identifier.issn | 1537-6591 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | |
| dc.relation.isversionof | 10.1093/cid/ciac159 | |
| dc.subject | UW Covid-19 SOT Study Team | |
| dc.title | Delayed mortality among solid organ transplant recipients hospitalized for COVID-19. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Heldman, Madeleine R|0000-0002-9424-1870 | |
| duke.contributor.orcid | Steinbrink, Julie M|0000-0003-0771-3647 | |
| duke.contributor.orcid | Alexander, Barbara D|0000-0001-5868-0529 | |
| pubs.begin-page | ciac159 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.publication-status | Published |
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