SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

dc.contributor.author

Huot, Nicolas

dc.contributor.author

Rascle, Philippe

dc.contributor.author

Petitdemange, Caroline

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Contreras, Vanessa

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Stürzel, Christina M

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Baquero, Eduard

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Harper, Justin L

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Passaes, Caroline

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Legendre, Rachel

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Varet, Hugo

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Madec, Yoann

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Sauermann, Ulrike

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Stahl-Hennig, Christiane

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Nattermann, Jacob

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Saez-Cirion, Asier

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Le Grand, Roger

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Keith Reeves, R

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Paiardini, Mirko

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Kirchhoff, Frank

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Jacquelin, Beatrice

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Müller-Trutwin, Michaela

dc.date.accessioned

2021-10-01T13:52:36Z

dc.date.available

2021-10-01T13:52:36Z

dc.date.issued

2021-02-24

dc.date.updated

2021-10-01T13:52:32Z

dc.description.abstract

Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.

dc.identifier

10.1038/s41467-021-21402-1

dc.identifier.issn

2041-1723

dc.identifier.issn

2041-1723

dc.identifier.uri

https://hdl.handle.net/10161/23870

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Nature communications

dc.relation.isversionof

10.1038/s41467-021-21402-1

dc.subject

Lymphoid Tissue

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Lymph Nodes

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Killer Cells, Natural

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CD4-Positive T-Lymphocytes

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K562 Cells

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Animals

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Macaca

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Humans

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Simian Acquired Immunodeficiency Syndrome

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Fluorescent Antibody Technique

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Flow Cytometry

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Cell Differentiation

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Algorithms

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Female

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Male

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Simian immunodeficiency virus

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NK Cell Lectin-Like Receptor Subfamily C

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Transcriptome

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Chlorocebus aethiops

dc.title

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

dc.type

Journal article

pubs.begin-page

1282

pubs.issue

1

pubs.organisational-group

School of Medicine

pubs.organisational-group

Surgery, Surgical Sciences

pubs.organisational-group

Duke

pubs.organisational-group

Surgery

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

12

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