The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

dc.contributor.author

Rozenblatt-Rosen, Orit

dc.contributor.author

Regev, Aviv

dc.contributor.author

Oberdoerffer, Philipp

dc.contributor.author

Nawy, Tal

dc.contributor.author

Hupalowska, Anna

dc.contributor.author

Rood, Jennifer E

dc.contributor.author

Ashenberg, Orr

dc.contributor.author

Cerami, Ethan

dc.contributor.author

Coffey, Robert J

dc.contributor.author

Demir, Emek

dc.contributor.author

Ding, Li

dc.contributor.author

Esplin, Edward D

dc.contributor.author

Ford, James M

dc.contributor.author

Goecks, Jeremy

dc.contributor.author

Ghosh, Sharmistha

dc.contributor.author

Gray, Joe W

dc.contributor.author

Guinney, Justin

dc.contributor.author

Hanlon, Sean E

dc.contributor.author

Hughes, Shannon K

dc.contributor.author

Hwang, E Shelley

dc.contributor.author

Iacobuzio-Donahue, Christine A

dc.contributor.author

Jané-Valbuena, Judit

dc.contributor.author

Johnson, Bruce E

dc.contributor.author

Lau, Ken S

dc.contributor.author

Lively, Tracy

dc.contributor.author

Mazzilli, Sarah A

dc.contributor.author

Pe'er, Dana

dc.contributor.author

Santagata, Sandro

dc.contributor.author

Shalek, Alex K

dc.contributor.author

Schapiro, Denis

dc.contributor.author

Snyder, Michael P

dc.contributor.author

Sorger, Peter K

dc.contributor.author

Spira, Avrum E

dc.contributor.author

Srivastava, Sudhir

dc.contributor.author

Tan, Kai

dc.contributor.author

West, Robert B

dc.contributor.author

Williams, Elizabeth H

dc.contributor.author

Human Tumor Atlas Network

dc.date.accessioned

2020-05-01T13:27:37Z

dc.date.available

2020-05-01T13:27:37Z

dc.date.issued

2020-04

dc.date.updated

2020-05-01T13:27:34Z

dc.description.abstract

Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.

dc.identifier

S0092-8674(20)30346-9

dc.identifier.issn

0092-8674

dc.identifier.issn

1097-4172

dc.identifier.uri

https://hdl.handle.net/10161/20573

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Cell

dc.relation.isversionof

10.1016/j.cell.2020.03.053

dc.subject

Human Tumor Atlas Network

dc.title

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

dc.type

Journal article

duke.contributor.orcid

Hwang, E Shelley|0000-0002-8571-1148

pubs.begin-page

236

pubs.end-page

249

pubs.issue

2

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Biostatistics & Bioinformatics

pubs.organisational-group

Duke

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Basic Science Departments

pubs.publication-status

Published

pubs.volume

181

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
PIIS0092867420303469.pdf
Size:
2.66 MB
Format:
Adobe Portable Document Format
Description:
Published version