Point-of-care diagnostics for invasive aspergillosis: nearing the finish line.

dc.contributor.author

Jenks, Jeffrey D

dc.contributor.author

Hoenigl, Martin

dc.date.accessioned

2023-08-01T17:53:08Z

dc.date.available

2023-08-01T17:53:08Z

dc.date.issued

2020-10

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2023-08-01T17:53:08Z

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Introduction

The spectrum of disease caused by Aspergillus spp. is dependent on the immune system of the host, with invasive aspergillosis (IA) its most severe manifestation. Early and reliable diagnosis of Aspergillus disease is important to decrease associated morbidity and mortality from IA.

Areas covered

The following review searched Pub Med for literature published since 2007 and will give an update on the current point-of-care diagnostic strategies for the diagnosis of IA, discuss needed areas of improvement for these tests, and future directions.

Expert opinion

Several new diagnostic tests for IA - including point-of-care tests - are now available to complement conventional galactomannan (GM) testing. In particular, the Aspergillus-specific Lateral Flow Device (LFD) test and the sōna Aspergillus GM Lateral Flow Assay (LFA) are promising for the diagnosis of IA in patients with hematologic malignancy, although further evaluation in the non-hematology setting is needed. In addition, a true point-of-care test, particularly for easily obtained specimens like serum or urine that can be done at the bedside or in the Clinic in a matter of minutes is needed, such as the lateral flow dipstick test, which is under current evaluation. Lastly, improved diagnostic algorithms to diagnose IA in non-neutropenic patients is needed.
dc.identifier.issn

1473-7159

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1744-8352

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https://hdl.handle.net/10161/28620

dc.language

eng

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Informa UK Limited

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Expert review of molecular diagnostics

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10.1080/14737159.2020.1820864

dc.subject

Humans

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Aspergillosis

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Disease Susceptibility

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Sensitivity and Specificity

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Reproducibility of Results

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Algorithms

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Disease Management

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Clinical Decision-Making

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Point-of-Care Testing

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Invasive Fungal Infections

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Point-of-care diagnostics for invasive aspergillosis: nearing the finish line.

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Journal article

duke.contributor.orcid

Jenks, Jeffrey D|0000-0001-6632-9587

pubs.begin-page

1009

pubs.end-page

1017

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10

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Duke

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School of Medicine

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Clinical Science Departments

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Medicine

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Medicine, Infectious Diseases

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Published

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20

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