Electrically evoked saccades from the dorsomedial frontal cortex and frontal eye fields: a parametric evaluation reveals differences between areas.

dc.contributor.author

Tehovnik, EJ

dc.contributor.author

Sommer, MA

dc.coverage.spatial

Germany

dc.date.accessioned

2016-03-25T03:27:24Z

dc.date.issued

1997-12

dc.description.abstract

Using electrical stimulation to evoke saccades from the dorsomedial frontal cortex (DMFC) and frontal eye fields (FEF) of rhesus monkeys, parametric tests were conducted to compare the excitability properties of these regions. Pulse frequency and pulse current, pulse frequency and train duration, and pulse current and pulse duration were varied to determine threshold functions for a 50% probability of evoking a saccade. Also a wide range of frequencies were tested to evoke saccades, while holding all other parameters constant. For frequencies beyond 150 Hz, the probability of evoking saccades decreased for the DMFC, whereas for the FEF this probability remained at 100%. To evoke saccades readily from the DMFC, train durations of greater than 200 ms were needed; for the FEF, durations of less than 100 ms were sufficient. Even though the chronaxies of neurons residing in the DMFC and FEF were similar (ranging from 0.1 to 0.24 ms) significantly higher currents were required to evoke saccades from the DMFC than FEF. Thus the stimulation parameters that are optimal for evoking saccades from the DMFC differ from those that are optimal for evoking saccades from the FEF. Although the excitability of neurons in the DMFC and FEF are similar (due to similar chronaxies), we suggest that the density of saccade-relevant neurons is higher in the FEF than in the DMFC.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/9438704

dc.identifier.issn

0014-4819

dc.identifier.uri

https://hdl.handle.net/10161/11760

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Exp Brain Res

dc.subject

Animals

dc.subject

Chronaxy

dc.subject

Electric Stimulation

dc.subject

Fixation, Ocular

dc.subject

Frontal Lobe

dc.subject

Macaca mulatta

dc.subject

Neurons

dc.subject

Saccades

dc.subject

Visual Fields

dc.title

Electrically evoked saccades from the dorsomedial frontal cortex and frontal eye fields: a parametric evaluation reveals differences between areas.

dc.type

Journal article

duke.contributor.orcid

Sommer, MA|0000-0001-5061-763X

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/9438704

pubs.begin-page

369

pubs.end-page

378

pubs.issue

3

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Biomedical Engineering

pubs.organisational-group

Center for Cognitive Neuroscience

pubs.organisational-group

Duke

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

Neurobiology

pubs.organisational-group

Pratt School of Engineering

pubs.organisational-group

School of Medicine

pubs.organisational-group

University Institutes and Centers

pubs.publication-status

Published

pubs.volume

117

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
TehovnikSommer1997.pdf
Size:
450.84 KB
Format:
Adobe Portable Document Format
Description:
Published version