Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Parker, Daniel

Sloane, Richard

Pieper, Carl F

Hall, Katherine S

Kraus, Virginia B

Kraus, William E

Huebner, Janet L

Ilkayeva, Olga R

Bain, James R

Newby, L Kristin

Cohen, Harvey Jay

Morey, Miriam C

2018-07-30T18:09:37Z

2018-07-30T18:09:37Z

2018-05-22

2018-07-30T18:09:36Z

Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers in adults aged 30 to over 80. Biomarkers were quantified in 961 adults. Tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor I (TNFR-I), tumor necrosis factor receptor II (TNFR-II), interleukin (IL)-2, IL-6, VCAM-I, D-Dimer, G-CSF, regulated on activation, normal T cell expressed and secreted (RANTES), matrix metalloproteinase-3 (MMP-3), adiponectin, and paraoxonase activity were measured by ELISA. Acylcarnitines and amino acids (AAs) were measured by mass spectrometry and reduced to a single factor using principal components analysis (PCA). Glycine was analyzed separately. The relationship between age and biomarkers was analyzed by linear regression with sex, race, and body mass index (BMI) as covariates. Age was positively correlated with TNF-α, TNFR-I, TNFR-II, IL-6, IL-2, VCAM-1, D-Dimer, MMP-3, adiponectin, acylcarnitines, and AAs. Age was negative correlated with G-CSF, RANTES, and paraoxonase activity. BMI was significant for all biomarkers except IL-2, VCAM-1, RANTES, paraoxonase activity, and the AA factor. Excluding MMP-3, greater BMI was associated with potentially adverse changes in biomarker concentrations. Age-related changes in immune and metabolic biomarkers, known to be associated with poor outcomes in older adults, begin as early as the thirties.

1079-5006

1758-535X

https://hdl.handle.net/10161/17283

Oxford University Press (OUP)

The journals of gerontology. Series A, Biological sciences and medical sciences

10.1093/gerona/gly121

Science & Technology

Life Sciences & Biomedicine

Geriatrics & Gerontology

Gerontology

Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Conference

Parker, Daniel|0000-0001-8512-1044

Pieper, Carl F|0000-0003-4809-1725

Kraus, Virginia B|0000-0001-8173-8258

Kraus, William E|0000-0003-1930-9684

Ilkayeva, Olga R|0000-0002-9779-0883

Bain, James R|0000-0002-8917-9187

Newby, L Kristin|0000-0002-6394-8187

S226

S226

School of Medicine

Duke

Center for the Study of Aging and Human Development

Institutes and Centers

Medicine, Endocrinology, Metabolism, and Nutrition

Medicine

Clinical Science Departments

Sarah Stedman Nutrition & Metabolism Center

Duke Molecular Physiology Institute

Duke Clinical Research Institute

Medicine, Cardiology

Published

66