S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair.

dc.contributor.author

Nandate, Koichiro

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Sharma, Deepak

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Olivar, Hernando

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Hallman, Matthew

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Ramaiah, Ramesh

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Joffe, Aaron

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Roche, Anthony

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Krishnamoorthy, Vijay

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United States

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2017-11-09T18:52:44Z

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2017-11-09T18:52:44Z

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2017

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BACKGROUND: Thoracic Endovascular Aortic Repair (TEVAR) has substantially decreased the mortality and major complications from aortic surgery. However, neurological complications such as spinal cord ischemia may still occur after TEVAR. S-100β is a biomarker of central nervous system injury, and oxidant injury plays an important role in neurological injury. In this pilot study, we examined the trends of S-100β and antioxidant capacity in the CSF during and after TEVAR. METHODS: We recruited 10 patients who underwent elective TEVAR. CSF samples were collected through a lumbar catheter at the following time points: before the start of surgery (T0) and immediately (T1) and 24 (T2) and 48 hours (T3) after the deployment of the aortic stent. S-100β and CSF antioxidant capacity were analyzed with the use of commercially available kits. RESULTS: We observed that the level of S-100β in all of the subjects at 24 hours after the deployment of the aortic stent (T2) increased. However, the levels of S-100β at T1 and T3 were comparable to the baseline value. The antioxidant capacity remained unchanged. No patient had a clinical neurologic complication. CONCLUSIONS: Our observations may indicate biochemical/subclinical central nervous system injury attributable to the deployment of the aortic stent.

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https://www.ncbi.nlm.nih.gov/pubmed/28740858

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2356-7872

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https://hdl.handle.net/10161/15741

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eng

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Hindawi Limited

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Int Sch Res Notices

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10.1155/2017/6875195

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S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair.

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Journal article

duke.contributor.orcid

Krishnamoorthy, Vijay|0000-0003-4153-2348

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https://www.ncbi.nlm.nih.gov/pubmed/28740858

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6875195

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Anesthesiology

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Anesthesiology, Critical Care Medicine

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Clinical Science Departments

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Duke

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School of Medicine

pubs.publication-status

Published online

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2017

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