S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair.
dc.contributor.author | Nandate, Koichiro | |
dc.contributor.author | Sharma, Deepak | |
dc.contributor.author | Olivar, Hernando | |
dc.contributor.author | Hallman, Matthew | |
dc.contributor.author | Ramaiah, Ramesh | |
dc.contributor.author | Joffe, Aaron | |
dc.contributor.author | Roche, Anthony | |
dc.contributor.author | Krishnamoorthy, Vijay | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2017-11-09T18:52:44Z | |
dc.date.available | 2017-11-09T18:52:44Z | |
dc.date.issued | 2017 | |
dc.description.abstract | BACKGROUND: Thoracic Endovascular Aortic Repair (TEVAR) has substantially decreased the mortality and major complications from aortic surgery. However, neurological complications such as spinal cord ischemia may still occur after TEVAR. S-100β is a biomarker of central nervous system injury, and oxidant injury plays an important role in neurological injury. In this pilot study, we examined the trends of S-100β and antioxidant capacity in the CSF during and after TEVAR. METHODS: We recruited 10 patients who underwent elective TEVAR. CSF samples were collected through a lumbar catheter at the following time points: before the start of surgery (T0) and immediately (T1) and 24 (T2) and 48 hours (T3) after the deployment of the aortic stent. S-100β and CSF antioxidant capacity were analyzed with the use of commercially available kits. RESULTS: We observed that the level of S-100β in all of the subjects at 24 hours after the deployment of the aortic stent (T2) increased. However, the levels of S-100β at T1 and T3 were comparable to the baseline value. The antioxidant capacity remained unchanged. No patient had a clinical neurologic complication. CONCLUSIONS: Our observations may indicate biochemical/subclinical central nervous system injury attributable to the deployment of the aortic stent. | |
dc.identifier | ||
dc.identifier.issn | 2356-7872 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Hindawi Limited | |
dc.relation.ispartof | Int Sch Res Notices | |
dc.relation.isversionof | 10.1155/2017/6875195 | |
dc.title | S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair. | |
dc.type | Journal article | |
duke.contributor.orcid | Krishnamoorthy, Vijay|0000-0003-4153-2348 | |
pubs.author-url | ||
pubs.begin-page | 6875195 | |
pubs.organisational-group | Anesthesiology | |
pubs.organisational-group | Anesthesiology, Critical Care Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.publication-status | Published online | |
pubs.volume | 2017 |
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