Modeling hematopoietic system response caused by chronic exposure to ionizing radiation.

Akushevich, Igor V

Veremeyeva, Galina A

Dimov, Georgy P

Ukraintseva, Svetlana V

Arbeev, Konstantin G

Akleyev, Alexander V

Yashin, Anatoly I

Germany

2017-06-06T17:16:57Z

2017-06-06T17:16:57Z

2011-05

A new model of the hematopoietic system response in humans chronically exposed to ionizing radiation describes the dynamics of the hematopoietic stem cell compartment as well as the dynamics of each of the four blood cell types (lymphocytes, neutrophiles, erythrocytes, and platelets). The required model parameters were estimated based on available results of human and experimental animal studies. They include the steady-state number of hematopoietic stem cells and peripheral blood cell lines in an unexposed organism, amplification parameters for each blood line, parameters describing proliferation and apoptosis, parameters of feedback functions regulating the steady-state numbers, and characteristics of radiosensitivity related to cell death and non-lethal cell damage. The model predictions were tested using data on hematological measurements (e.g., blood counts) performed in 1950-1956 in the Techa River residents chronically exposed to ionizing radiation since 1949. The suggested model of hematopoiesis is capable of describing experimental findings in the Techa River Cohort, including: (1) slopes of the dose-effect curves reflecting the inhibition of hematopoiesis due to chronic ionizing radiation, (2) delay in effect of chronic exposure and accumulated character of the effect, and (3) dose-rate patterns for different cytopenic states (e.g., leukopenia, thrombocytopenia).

https://www.ncbi.nlm.nih.gov/pubmed/21259022

1432-2099

https://hdl.handle.net/10161/14854

eng

Springer Science and Business Media LLC

Radiat Environ Biophys

10.1007/s00411-011-0351-3

Blood Platelets

Computer Simulation

Dose-Response Relationship, Radiation

Erythrocytes

Feedback

Hematopoiesis

Hematopoietic Stem Cells

Hematopoietic System

Humans

Lymphocytes

Models, Biological

Neutrophils

Radiation Injuries

Radiation Tolerance

Radiation, Ionizing

Stochastic Processes

Modeling hematopoietic system response caused by chronic exposure to ionizing radiation.

Journal article

Arbeev, Konstantin G|0000-0002-4195-7832

https://www.ncbi.nlm.nih.gov/pubmed/21259022

299

311

2

Center for Population Health & Aging

Duke

Duke Cancer Institute

Duke Population Research Center

Duke Population Research Institute

Institutes and Centers

Institutes and Provost's Academic Units

Physics

Sanford School of Public Policy

School of Medicine

Social Science Research Institute

Staff

Trinity College of Arts & Sciences

University Institutes and Centers

Published

50