Chemotactic movement of a polarity site enables yeast cells to find their mates.
| dc.contributor.author | Ghose, Debraj | |
| dc.contributor.author | Jacobs, Katherine | |
| dc.contributor.author | Ramirez, Samuel | |
| dc.contributor.author | Elston, Timothy | |
| dc.contributor.author | Lew, Daniel | |
| dc.date.accessioned | 2022-03-01T15:11:53Z | |
| dc.date.available | 2022-03-01T15:11:53Z | |
| dc.date.issued | 2021-06 | |
| dc.date.updated | 2022-03-01T15:11:53Z | |
| dc.description.abstract | How small eukaryotic cells can interpret dynamic, noisy, and spatially complex chemical gradients to orient growth or movement is poorly understood. We address this question using Saccharomyces cerevisiae, where cells orient polarity up pheromone gradients during mating. Initial orientation is often incorrect, but polarity sites then move around the cortex in a search for partners. We find that this movement is biased by local pheromone gradients across the polarity site: that is, movement of the polarity site is chemotactic. A bottom-up computational model recapitulates this biased movement. The model reveals how even though pheromone-bound receptors do not mimic the shape of external pheromone gradients, nonlinear and stochastic effects combine to generate effective gradient tracking. This mechanism for gradient tracking may be applicable to any cell that searches for a target in a complex chemical landscape. | |
| dc.identifier | 2025445118 | |
| dc.identifier.issn | 0027-8424 | |
| dc.identifier.issn | 1091-6490 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Proceedings of the National Academy of Sciences | |
| dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | |
| dc.relation.isversionof | 10.1073/pnas.2025445118 | |
| dc.subject | Saccharomyces cerevisiae | |
| dc.subject | Saccharomyces cerevisiae Proteins | |
| dc.subject | Computational Biology | |
| dc.subject | Chemotaxis | |
| dc.subject | Cell Polarity | |
| dc.title | Chemotactic movement of a polarity site enables yeast cells to find their mates. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Lew, Daniel|0000-0001-7482-3585 | |
| pubs.begin-page | e2025445118 | |
| pubs.end-page | e2025445118 | |
| pubs.issue | 22 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Cell Biology | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Pharmacology & Cancer Biology | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.publication-status | Published | |
| pubs.volume | 118 |
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