Periodic limb movements during sleep and risk of hypertension: A systematic review.

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2023-02

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Abstract

Background

Several studies suggest an association between periodic limb movements during sleep (PLMS) and hypertension; however, a systematic evaluation of this relationship is lacking.

Methods

We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio, comparing the risk of hypertension in persons with PLMS (defined by the level of periodic limb movements per hour of sleep depended on individual studies) versus those without PLMS. After assessing heterogeneity and bias, the pooled risk ratio and 95% confidence intervals (CIs) were determined using a random-effect, generic inverse variance method of DerSimonian and Laird.

Results

Out of 572 potentially relevant articles, six eligible studies were included in the data analysis. Studies (6 cross-sectional) included 8949 participants. The statistical heterogeneity of this study was insignificant, with an I2 of 0%. A funnel plot and Egger's regression asymmetry test showed no publication bias with P-value ≥0.05. The pooled risk ratio of hypertension in patients with PLMS was 1.26 (95% CI, 1.12-1.41).

Conclusions

Our analysis demonstrates an increased hypertension risk among patients with PLMS. Prospective or interventional studies are needed to confirm this association.

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Humans, Nocturnal Myoclonus Syndrome, Hypertension, Polysomnography, Prospective Studies, Cross-Sectional Studies, Sleep

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https://hdl.handle.net/10161/29396

Published Version (Please cite this version)

10.1016/j.sleep.2023.01.008

Publication Info

Srivali, Narat, Charat Thongprayoon, Supawit Tangpanithandee, Pajaree Krisanapan, Michael A Mao, Andrey Zinchuk, Brain B Koo, Wisit Cheungpasitporn, et al. (2023). Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep medicine, 102. pp. 173–179. 10.1016/j.sleep.2023.01.008 Retrieved from https://hdl.handle.net/10161/29396.

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Srivali

Narat Srivali

Assistant Professor of Medicine

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