Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.

dc.contributor.author

Chang, AS

dc.contributor.author

Bennett, SM

dc.contributor.author

Noor, MAF

dc.coverage.spatial

United States

dc.date.accessioned

2011-06-21T17:32:21Z

dc.date.issued

2010-10-27

dc.description.abstract

The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibilities, often with limited success, suggesting that hybrid sterility and inviability are frequently caused by complex interactions between multiple loci and not by single or a small number of gene pairs. Our previous study showed that the nature of epistasis between sterility-conferring QTL in the Drosophila persimilis-D. pseudoobscura bogotana species pair is highly specific. Here, we further dissect one of the three QTL underlying hybrid male sterility between these species and provide evidence for multiple factors within this QTL. This result indicates that the number of loci thought to contribute to hybrid dysfunction may have been underestimated, and we discuss how linkage and complex epistasis may be characteristic of the genetics of hybrid incompatibilities. We further pinpoint the location of one locus that confers hybrid male sterility when homozygous, dubbed "mule-like", to roughly 250 kilobases.

dc.description.version

Version of Record

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/21060872

dc.identifier.eissn

1932-6203

dc.identifier.uri

https://hdl.handle.net/10161/4589

dc.language

eng

dc.language.iso

en_US

dc.publisher

Public Library of Science (PLoS)

dc.relation.ispartof

PLoS One

dc.relation.isversionof

10.1371/journal.pone.0015377

dc.relation.journal

Plos One

dc.subject

Animals

dc.subject

Chromosome Mapping

dc.subject

Drosophila

dc.subject

Epistasis, Genetic

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Infertility, Male

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Male

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Quantitative Trait Loci

dc.title

Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.

dc.title.alternative
dc.type

Journal article

duke.date.pubdate

2010-10-27

duke.description.issue

10

duke.description.volume

5

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/21060872

pubs.begin-page

e15377

pubs.issue

10

pubs.organisational-group

Biology

pubs.organisational-group

Duke

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.publication-status

Published online

pubs.volume

5

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