Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.

dc.contributor.author

Olson, Lyra B

dc.contributor.author

Naqvi, Ibtehaj A

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Turner, Daniel J

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Morrison, Sarah A

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Kraft, Bryan D

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Chen, Lingye

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Sullenger, Bruce A

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Nair, Smita K

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Que, Loretta G

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Levy, Jerrold H

dc.date.accessioned

2021-04-01T13:38:58Z

dc.date.available

2021-04-01T13:38:58Z

dc.date.issued

2021-03-30

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2021-04-01T13:38:57Z

dc.description.abstract

The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown. Patients with leukemia may display altered thromboinflammatory responses. We report a 53-year-old man presenting with acute leukemia and COVID-19 who developed thrombotic complications and acute respiratory distress syndrome. Multiple analyses, including rotational thromboelastometry and flow cytometry on blood and bronchoalveolar lavage, are reported to characterize coagulation and immune profiles. The patient developed chemotherapy-induced neutropenia that may have protected his lungs from granulocyte-driven hyperinflammatory acute lung injury. However, neutropenia also alters viral clearing, potentially enabling ongoing viral propagation. This case depicts a precarious equilibrium between leukemia and COVID-19.

dc.identifier

02054229-202104000-00009

dc.identifier.issn

2575-3126

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2575-3126

dc.identifier.uri

https://hdl.handle.net/10161/22473

dc.language

eng

dc.publisher

Ovid Technologies (Wolters Kluwer Health)

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A&A practice

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10.1213/xaa.0000000000001432

dc.title

Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report.

dc.type

Journal article

duke.contributor.orcid

Nair, Smita K|0000-0001-7019-1912

duke.contributor.orcid

Levy, Jerrold H|0000-0003-3766-4962

pubs.begin-page

e01432

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4

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School of Medicine

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Surgery, Cardiovascular and Thoracic Surgery

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Anesthesiology, Cardiothoracic

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Duke

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Surgery

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Clinical Science Departments

pubs.organisational-group

Anesthesiology

pubs.publication-status

Published

pubs.volume

15

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