Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE.

Sundman, Mark

Doraiswamy, P Murali

Morey, Rajendra A

Switzerland

2015-12-03T14:34:13Z

2015

Traumatic brain injury (TBI) has been increasingly accepted as a major external risk factor for neurodegenerative morbidity and mortality. Recent evidence indicates that the resultant chronic neurobiological sequelae following head trauma may, at least in part, contribute to a pathologically distinct disease known as Chronic Traumatic Encephalopathy (CTE). The clinical manifestation of CTE is variable, but the symptoms of this progressive disease include impaired memory and cognition, affective disorders (i.e., impulsivity, aggression, depression, suicidality, etc.), and diminished motor control. Notably, mounting evidence suggests that the pathology contributing to CTE may be caused by repetitive exposure to subconcussive hits to the head, even in those with no history of a clinically evident head injury. Given the millions of athletes and military personnel with potential exposure to repetitive subconcussive insults and TBI, CTE represents an important public health issue. However, the incidence rates and pathological mechanisms are still largely unknown, primarily due to the fact that there is no in vivo diagnostic tool. The primary objective of this manuscript is to address this limitation and discuss potential neuroimaging modalities that may be capable of diagnosing CTE in vivo through the detection of tau and other known pathological features. Additionally, we will discuss the challenges of TBI research, outline the known pathology of CTE (with an emphasis on Tau), review current neuroimaging modalities to assess the potential routes for in vivo diagnosis, and discuss the future directions of CTE research.

http://www.ncbi.nlm.nih.gov/pubmed/26441507

1662-4548

https://hdl.handle.net/10161/10960

eng

Frontiers Media SA

Front Neurosci

10.3389/fnins.2015.00334

Chronic Traumatic Encephalopathy (CTE)

Positron Emission Tomography (PET)

Tau

Traumatic brain injury (TBI)

concussion

neuroimaging

Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/26441507

334

Clinical Science Departments

Duke

Duke Institute for Brain Sciences

Duke Science & Society

Duke-UNC Center for Brain Imaging and Analysis

Initiatives

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Geriatrics

Psychiatry & Behavioral Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience

School of Medicine

University Institutes and Centers

Published online

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