RIPK3: Beyond Necroptosis.

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2019-01

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Abstract

In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.

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10.1016/j.immuni.2018.12.031

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Evans, Azia S, and Carolyn B Coyne (2019). RIPK3: Beyond Necroptosis. Immunity, 50(1). pp. 1–3. 10.1016/j.immuni.2018.12.031 Retrieved from https://hdl.handle.net/10161/22580.

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Coyne

Carolyn Coyne

George Barth Geller Distinguished Professor of Immunology

We study the pathways by which microorganisms cross cellular barriers and the mechanisms by which these barriers restrict microbial infections. Our studies primarily focus on the epithelium that lines the gastrointestinal tract and on placental trophoblasts, the cells that comprise a key cellular barrier of the human placenta. Our work is highly multidisciplinary and encompasses aspects of cell biology, immunology, and microbiology. Our long-term goals are to identify pathogen- and host-specific therapeutic targets to prevent or treat microbial infections and ultimately to alleviate the morbidity and mortality caused by these infections.


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