Long-term outcome and impact of surgery on adults with coronary arteries originating from the opposite coronary cusp.

dc.contributor.author

Krasuski, Richard A

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Magyar, Dari

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Hart, Stephen

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Kalahasti, Vidyasagar

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Lorber, Richard

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Hobbs, Robert

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Pettersson, Gosta

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Blackstone, Eugene

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United States

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2015-12-03T17:52:03Z

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2011-01-18

dc.description.abstract

BACKGROUND: An anomalous coronary artery from the opposite sinus of Valsalva may increase sudden death risk in children and young adults, and surgical intervention is often recommended. The impact of this lesion when recognized in the adult and its management are ill defined. METHODS AND RESULTS: We reviewed 210 700 cardiac catheterizations performed over a 35-year period at a single institution and identified 301 adults with an anomalous coronary artery from the opposite sinus of Valsalva, either anomalous right coronary artery from the left cusp or anomalous left main coronary artery from the right cusp. Patients were stratified by the pathway of the anomalous artery and the chosen treatment. Among the 301 patients with anomalous coronary artery from the opposite sinus of Valsalva (0.14% of the cohort), 79% had anomalous right coronary artery from the left cusp, and 18% had an interarterial course (IAC). Patients with IAC were younger (52±13 versus 59±13 years; P=0.001) and more likely to undergo surgical intervention (52% versus 27%; P<0.001), but mortality was not increased with IAC. Among the 54 patients with IAC, 28 underwent surgical repair with no perioperative deaths. Patients evaluated since 2000 were significantly more likely to be referred for surgery (P=0.004). Surgical patients were more likely to have abnormal stress tests (90% versus 43%; P=0.01) and had more extensive atherosclerosis but less diabetes mellitus (0% versus 23%; P=0.01). Long-term survival at 10 years appeared similar in both groups. CONCLUSIONS: In this single-center cohort study of patients with an anomalous coronary artery from the opposite sinus of Valsalva, surgical management appears to have been favored recently. Despite no perioperative mortality, a positive impact on long-term survival was not observed. The impact of surgery in older adults with anomalous coronary arteries arising from the opposite coronary sinus with IAC deserves further study.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/21200009

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CIRCULATIONAHA.109.921106

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1524-4539

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https://hdl.handle.net/10161/11032

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eng

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Ovid Technologies (Wolters Kluwer Health)

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Circulation

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10.1161/CIRCULATIONAHA.109.921106

dc.subject

Adult

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Aged

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Cardiac Catheterization

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Cohort Studies

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Coronary Vessel Anomalies

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Coronary Vessels

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Female

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Humans

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Male

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Middle Aged

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Myocardial Revascularization

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Retrospective Studies

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Sinus of Valsalva

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Survival Rate

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Thoracic Arteries

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Treatment Outcome

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Vascular Surgical Procedures

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Long-term outcome and impact of surgery on adults with coronary arteries originating from the opposite coronary cusp.

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Journal article

duke.contributor.orcid

Krasuski, Richard A|0000-0003-3150-5215

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/21200009

pubs.begin-page

154

pubs.end-page

162

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2

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Clinical Science Departments

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Duke

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Medicine

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Medicine, Cardiology

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School of Medicine

pubs.publication-status

Published

pubs.volume

123

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