The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle.

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2021-10-22

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Abstract

Abstract

Inducible heme oxygenase (HO)-1 catalyzes the breakdown of heme to biliverdin, iron and carbon monoxide (CO). CO binds to cytochrome c oxidase and alters mitochondrial redox balance and coordinately regulates mitochondrial quality control (MQC) during oxidant stress and inflammation. The hypothesis presented is that skeletal muscle HO-1/CO system helps modulate components in the MQC cycle during metabolic stress.

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10.1249/jes.0000000000000277

Publication Info

Gasier, Heath G, Hagir B Suliman and Claude A Piantadosi (2021). The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle. Exercise and sport sciences reviews, Publish Ahead of Print. 10.1249/jes.0000000000000277 Retrieved from https://hdl.handle.net/10161/24126.

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Scholars@Duke

Gasier

Heath Gasier

Associate Professor in Anesthesiology

Dr. Gasier is a physiologist and nutritionist. His research is focused on understanding how breathing altered PO2 impacts cell physiology in the lung, brain, and skeletal muscle. Emphasis is placed on mitochondrial quality control (dynamics, mitophagy, and biogenesis) and bioenergetics. He uses in vivo and in vitro models, and employs an array of methods (e.g., confocal and electron microscopy, Seahorse respiration, immunoblotting, RT-qPCR, ELISA’s, isotope tracers, and 10X genomics) for hypothesis testing. The goal of his research is to improve the operational capacity of divers and safety of hyperoxia in hyperbaric and critical care medicine. Dr. Gasier believes in a hands-on mentoring approach and individualized training plans based on mentee’s aspirations. He is committed to lifetime learning and contributing to knowledge advancement. 


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