<i>Curvularia alcornii</i> Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.


We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical intervention and antifungal therapy, infection progressed. We review the literature on invasive Curvularia infection to inform diagnosis and management.





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Publication Info

Narayanasamy, Shanti, Adam R Williams, Wiley A Schell, Rebekah W Moehring, Barbara D Alexander, Thuy Le, Ramesh A Bharadwaj, Michelle McGauvran, et al. (2021). Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature. Open forum infectious diseases, 8(11). p. ofab536. 10.1093/ofid/ofab536 Retrieved from https://hdl.handle.net/10161/26021.

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Shanti Narayanasamy

Adjunct Assistant Professor of Global Health

Adam Richard Williams

Assistant Professor of Surgery

Wiley Alexander Schell

Associate Professor Emeritus in Medicine

Rebekah Moehring

Associate Professor of Medicine

Barbara Dudley Alexander

Professor of Medicine

Clinical research related to infectious complications of solid organ and bone marrow transplantation, with a particular interest in the treatment and rapid diagnosis of fungal disease. Training the next generation of Transplant Infectious Disease Physicians is a special focus of mine as the Principal Investigator of our Interdisciplinary T32 Training Program funded the NIH. 


Thuy Le

Associate Professor of Medicine

Jacob Niall Schroder

Assistant Professor of Surgery

John Robert Perfect

James B. Duke Distinguished Professor of Medicine

Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.

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