<i>Curvularia alcornii</i> Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.
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2021-11
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We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical intervention and antifungal therapy, infection progressed. We review the literature on invasive Curvularia infection to inform diagnosis and management.
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Narayanasamy, Shanti, Adam R Williams, Wiley A Schell, Rebekah W Moehring, Barbara D Alexander, Thuy Le, Ramesh A Bharadwaj, Michelle McGauvran, et al. (2021). Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature. Open forum infectious diseases, 8(11). p. ofab536. 10.1093/ofid/ofab536 Retrieved from https://hdl.handle.net/10161/26021.
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Scholars@Duke
Shanti Narayanasamy
Adam Richard Williams
Wiley Alexander Schell
Rebekah Moehring
My research is focused on optimizing the use of antimicrobials and preventing healthcare-associated infections via interventions made by antimicrobial stewardship programs in acute care hospitals. I aim to develop, implement, and evaluate the utility of outcomes important in assessing the success of hospital antimicrobial stewardship programs, which will then serve as a means to optimize program development. I am also an active clinician with expertise in the diagnosis and treatment of infectious diseases. I am uniquely positioned to study antimicrobial stewardship program optimization in my role as Co-director for Research of the Duke Antimicrobial Stewardship Outreach Network. This network’s mission is to develop practical approaches and support for implementation of antimicrobial stewardship in the community hospital setting, which includes outcomes assessments that utilize benchmarking to network data. This network is made up of >30 community hospitals which share a common data infrastructure, access to comparative antimicrobial use data, consultation with Duke liaison pharmacists and physicians, and educational materials. In addition, I serve as medical director of the Duke University Hospital Antimicrobial Stewardship and Evaluation Team (ASET) and actively practice front-line stewardship at my home institution.
Barbara Dudley Alexander
Clinical research related to infectious complications of solid organ and bone marrow transplantation, with a particular interest in the treatment and rapid diagnosis of fungal disease. Training the next generation of Transplant Infectious Disease Physicians is a special focus of mine as the Principal Investigator of our Interdisciplinary T32 Training Program funded the NIH.
Thuy Le
Jacob Niall Schroder
John Robert Perfect
Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.
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