<i>Curvularia alcornii</i> Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.

Abstract

We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical intervention and antifungal therapy, infection progressed. We review the literature on invasive Curvularia infection to inform diagnosis and management.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1093/ofid/ofab536

Publication Info

Narayanasamy, Shanti, Adam R Williams, Wiley A Schell, Rebekah W Moehring, Barbara D Alexander, Thuy Le, Ramesh A Bharadwaj, Michelle McGauvran, et al. (2021). Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature. Open forum infectious diseases, 8(11). p. ofab536. 10.1093/ofid/ofab536 Retrieved from https://hdl.handle.net/10161/26021.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Scholars@Duke

Narayanasamy

Shanti Narayanasamy

Adjunct Assistant Professor of Global Health
Williams

Adam Richard Williams

Assistant Professor of Surgery
Schell

Wiley Alexander Schell

Associate Professor Emeritus in Medicine
Moehring

Rebekah Moehring

Associate Professor of Medicine
Alexander

Barbara Dudley Alexander

Professor of Medicine

Clinical research related to infectious complications of solid organ and bone marrow transplantation, with a particular interest in the treatment and rapid diagnosis of fungal disease. Training the next generation of Transplant Infectious Disease Physicians is a special focus of mine as the Principal Investigator of our Interdisciplinary T32 Training Program funded the NIH. 

Le

Thuy Le

Associate Professor of Medicine
Schroder

Jacob Niall Schroder

Assistant Professor of Surgery
Perfect

John Robert Perfect

James B. Duke Distinguished Professor of Medicine

Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.