Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers.

Meyer, Sarah A

Westreich, Daniel J

Patel, Emily

Ehlinger, Elizabeth P

Kalilani, Linda

Lovingood, Rachel V

Denny, Thomas N

Swamy, Geeta K

Permar, Sallie R

Egypt

2017-04-01T20:34:51Z

2017-04-01T20:34:51Z

2014

HIV-1 and CMV are important pathogens transmitted via breastfeeding. Furthermore, perinatal CMV transmission may impact growth and disease progression in HIV-exposed infants. Although maternal antiretroviral therapy reduces milk HIV-1 RNA load and postnatal transmission, its impact on milk CMV load is unclear. We examined the relationship between milk CMV and HIV-1 load (4-6 weeks postpartum) and the impact of antiretroviral treatment in 69 HIV-infected, lactating Malawian women and assessed the relationship between milk CMV load and postnatal growth in HIV-exposed, breastfed infants through six months of age. Despite an association between milk HIV-1 RNA and CMV DNA load (0.39 log(10) rise CMV load per log(10) rise HIV-1 RNA load, 95% CI 0.13-0.66), milk CMV load was similar in antiretroviral-treated and untreated women. Higher milk CMV load was associated with lower length-for-age (-0.53, 95% CI: -0.96, -0.10) and weight-for-age (-0.40, 95% CI: -0.67, -0.13) Z-score at six months in exposed, uninfected infants. As the impact of maternal antiretroviral therapy on the magnitude of postnatal CMV exposure may be limited, our findings of an inverse relationship between infant growth and milk CMV load highlight the importance of defining the role of perinatal CMV exposure on growth faltering of HIV-exposed infants.

https://www.ncbi.nlm.nih.gov/pubmed/24723745

1098-0997

https://hdl.handle.net/10161/13925

eng

Hindawi Limited

Infect Dis Obstet Gynecol

10.1155/2014/989721

Adult

Anti-Retroviral Agents

Body Height

Body Weight

Breast Feeding

Cohort Studies

Cytomegalovirus Infections

DNA, Viral

Female

HIV Infections

Humans

Infectious Disease Transmission, Vertical

Mastitis

Milk, Human

Mothers

Young Adult

Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers.

Journal article

Swamy, Geeta K|0000-0001-5092-6993

https://www.ncbi.nlm.nih.gov/pubmed/24723745

989721

Basic Science Departments

Clinical Science Departments

Duke

Duke Human Vaccine Institute

Global Health Institute

Immunology

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Duke Human Vaccine Institute

Midwifery Service

Molecular Genetics and Microbiology

Obstetrics and Gynecology

Obstetrics and Gynecology, Maternal Fetal Medicine

Pediatrics

Pediatrics, Infectious Diseases

School of Medicine

University Institutes and Centers

Published

2014