Genomic and Functional Variation at a Normal Human Centromere

dc.contributor.advisor	Sullivan, Beth A
dc.contributor.author	AldrupMacDonald, Megan Elizabeth
dc.date.accessioned	2015-09-01T20:10:27Z
dc.date.available	2016-07-01T04:30:05Z
dc.date.issued	2015
dc.department	Genetics and Genomics
dc.description.abstract	Centromeres are chromosomal loci essential for genome stability. Their malfunction can cause chromosome instability associated with cancer, infertility, and birth defects. This study focused on an intriguing centromere on human chromosome 17, which displays normal functional variation. Centromere identity can be found on either of two large arrays of repetitive DNA. We investigated inter-individual sequence variation on these two arrays and found association between array size, array variation, and centromere function. Our data suggest a functional influence of DNA sequence at this critical epigenetic locus.
dc.identifier.uri	https://hdl.handle.net/10161/10555
dc.subject	Genetics
dc.subject	Biology
dc.subject	Molecular biology
dc.subject	alpha satellite DNA
dc.subject	Centromere
dc.subject	human variation
dc.title	Genomic and Functional Variation at a Normal Human Centromere
dc.type	Master's thesis
duke.embargo.months	10

Files

Now showing 1 - 1 of 1