Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways.
| dc.contributor.author | Chen, Po-Han | |
| dc.contributor.author | Chi, Jen-Tsan | |
| dc.contributor.author | Boyce, Michael | |
| dc.date.accessioned | 2020-01-01T16:55:44Z | |
| dc.date.available | 2020-01-01T16:55:44Z | |
| dc.date.issued | 2018-08 | |
| dc.date.updated | 2020-01-01T16:55:44Z | |
| dc.description.abstract | In metazoans, thousands of intracellular proteins are modified with O-linked β-N-acetylglucosamine (O-GlcNAc) in response to a wide range of stimuli and stresses. In particular, a complex and evolutionarily conserved interplay between O-GlcNAcylation and oxidative stress has emerged in recent years. Here, we review the current literature on the connections between O-GlcNAc and oxidative stress, with a particular emphasis on major signaling pathways, such as KEAP1/NRF2, FOXO, NFκB, p53 and cell metabolism. Taken together, this work sheds important light on the signaling functions of protein glycosylation and the mechanisms of stress responses alike and illuminates how the two are integrated in animal cell physiology. | |
| dc.identifier | 4935241 | |
| dc.identifier.issn | 0959-6658 | |
| dc.identifier.issn | 1460-2423 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Glycobiology | |
| dc.relation.isversionof | 10.1093/glycob/cwy027 | |
| dc.subject | Animals | |
| dc.subject | Humans | |
| dc.subject | Acetylglucosamine | |
| dc.subject | Signal Transduction | |
| dc.subject | Oxidative Stress | |
| dc.title | Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Chi, Jen-Tsan|0000-0003-3433-903X | |
| duke.contributor.orcid | Boyce, Michael|0000-0002-2729-4876 | |
| pubs.begin-page | 556 | |
| pubs.end-page | 564 | |
| pubs.issue | 8 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Pharmacology & Cancer Biology | |
| pubs.organisational-group | Radiation Oncology | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine, Rheumatology and Immunology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Biochemistry | |
| pubs.publication-status | Published | |
| pubs.volume | 28 |