Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
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2016-01
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Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
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Galloway-Peña, Jessica, Meredith E Clement, Batu K Sharma Kuinkel, Felicia Ruffin, Anthony R Flores, Howard Levinson, Samuel A Shelburne, Zack Moore, et al. (2016). Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease. Open Forum Infect Dis, 3(1). p. ofw042. 10.1093/ofid/ofw042 Retrieved from https://hdl.handle.net/10161/13304.
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Scholars@Duke
Felicia Ruffin
Vance Garrison Fowler
Determinants of Outcome in Patients with Staphylococcus aureus Bacteremia
Antibacterial Resistance
Pathogenesis of Bacterial Infections
Tropical medicine/International Health
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