Vesicoureteral reflux and the extracellular matrix connection.

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2016-05-02

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Abstract

Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.

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10.1007/s00467-016-3386-5

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Tokhmafshan, Fatima, Patrick D Brophy, Rasheed A Gbadegesin and Indra R Gupta (2016). Vesicoureteral reflux and the extracellular matrix connection. Pediatr Nephrol. 10.1007/s00467-016-3386-5 Retrieved from https://hdl.handle.net/10161/12222.

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Scholars@Duke

Gbadegesin

Rasheed Adebayo Gbadegesin

Wilburt C. Davison Distinguished Professor

Molecular genetics of glomerular disease
Genetic risk factors for childhood onset idiopathic nephrotic syndrome


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