Pulmonary blastomycosis presenting as primary lung cancer.

dc.contributor.author

Hussaini, Syed Mohammed Qasim

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Madut, Deng

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Tong, Betty C

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Pavlisko, Elizabeth N

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Schell, Wiley A

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Perfect, John R

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Thielman, Nathan M

dc.date.accessioned

2019-06-21T17:45:28Z

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2019-06-21T17:45:28Z

dc.date.issued

2018-07-18

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2019-06-21T17:45:26Z

dc.description.abstract

BACKGROUND:Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentation of blastomycosis may easily be mistaken for other infectious or non-infectious etiologies. CASE PRESENTATION:We present the case of a 52-year-old African-American male and former smoker that presented to his primary care provider with a 2-week history of non-productive cough, night sweats and weight loss. Initially diagnosed with primary lung malignancy, the patient was subsequently found to have pulmonary blastomycosis mimicking lung cancer. The patient underwent a successful course of treatment with posaconazole. CONCLUSIONS:Chronic blastomycosis can present with clinical and radiographic features indistinguishable from thoracic malignancies. There is no clinical syndrome specific for blastomycosis, thus a high degree of suspicion is required for early diagnosis. In this case report, we review recent evidence in radiographic features, diagnostic considerations and treatment of the disease.

dc.identifier

10.1186/s12879-018-3244-0

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1471-2334

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1471-2334

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https://hdl.handle.net/10161/18966

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eng

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Springer Science and Business Media LLC

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BMC infectious diseases

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10.1186/s12879-018-3244-0

dc.subject

Lung

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Humans

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Blastomyces

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Blastomycosis

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Lung Neoplasms

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Triazoles

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DNA, Fungal

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Antifungal Agents

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Diagnosis, Differential

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Tomography, X-Ray Computed

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Middle Aged

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Male

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Positron Emission Tomography Computed Tomography

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Pulmonary blastomycosis presenting as primary lung cancer.

dc.type

Journal article

duke.contributor.orcid

Hussaini, Syed Mohammed Qasim|0000-0002-8006-5343

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Madut, Deng|0000-0003-4023-3928

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Tong, Betty C|0000-0002-3345-3124

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Pavlisko, Elizabeth N|0000-0001-9598-3369

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Perfect, John R|0000-0002-6606-9460|0000-0003-3465-5518

duke.contributor.orcid

Thielman, Nathan M|0000-0001-8152-2879

pubs.begin-page

336

pubs.issue

1

pubs.organisational-group

Staff

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Duke

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Medicine

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Clinical Science Departments

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School of Medicine

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Duke Global Health Institute

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Pathology

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Medicine, Infectious Diseases

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Duke Cancer Institute

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Institutes and Centers

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Surgery, Cardiovascular and Thoracic Surgery

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Surgery

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Molecular Genetics and Microbiology

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Basic Science Departments

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Published

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18

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