Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study.

Tyson, Crystal C

Lin, Pao-Hwa

Corsino, Leonor

Batch, Bryan C

Allen, Jenifer

Sapp, Shelly

Barnhart, Huiman

Nwankwo, Chinazo

Burroughs, Jasmine

Svetkey, Laura P

2018-12-01T16:33:06Z

2018-12-01T16:33:06Z

2016-08

2018-12-01T16:33:03Z

Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) for adults with normal kidney function, evidence is lacking regarding its safety and efficacy in chronic kidney disease (CKD). We aimed to test the effects of the DASH diet on serum electrolytes and BP in adults with moderate CKD.In a prospective before-after feeding study, 11 adults with an estimated glomerular filtration rate of 30-59 mL/min/1.73 m(2) and medication-treated hypertension were provided a reduced-sodium, run-in diet for 1 week followed by a reduced-sodium, DASH diet for 2 weeks. Changes in serum electrolytes and BP were compared pre-post DASH.Eleven participants underwent feeding; 1 completed 1 week and 10 completed 2 weeks of DASH. Compared with baseline, DASH modestly increased serum potassium at 1 week (mean ± standard deviation, +0.28 ± 0.4 mg/dL; P = 0.043) but had no significant effect on potassium at 2 weeks (+0.15 ± 0.28 mg/dL; P = 0.13). Serum bicarbonate was reduced (-2.5 ± 3.0 mg/dL; P = 0.03) at 2 weeks. Neither incident hyperkalemia nor new onset metabolic acidosis was observed. Clinic BP and mean 24-h ambulatory BP was unchanged. DASH significantly reduced mean nighttime BP (-5.3 ± 5.8 mmHg; P = 0.018), and enhanced percent declines in both nocturnal systolic BP (-2.1% to -5.1%; P = 0.004) and diastolic BP (-3.7% to -10.0%; P = 0.008).These pilot data suggest that a reduced-sodium DASH dietary pattern does not cause acute metabolic events in adults with moderate CKD and may improve nocturnal BP. Definitive studies are needed to determine long-term effects of DASH in CKD.

sfw046

2048-8505

2048-8513

https://hdl.handle.net/10161/17678

eng

Oxford University Press (OUP)

Clinical kidney journal

10.1093/ckj/sfw046

DASH diet

blood pressure

kidney disease

metabolic side effects

Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study.

Journal article

Lin, Pao-Hwa|0000-0001-5982-9241

Corsino, Leonor|0000-0001-6859-9097

Batch, Bryan C|0000-0002-7138-2064

Barnhart, Huiman|0000-0003-0988-3439

Svetkey, Laura P|0000-0002-3675-1282

592

598

4

School of Medicine

Duke

Duke Clinical Research Institute

Institutes and Centers

Biostatistics & Bioinformatics

Basic Science Departments

Medicine, Endocrinology, Metabolism, and Nutrition

Medicine

Clinical Science Departments

Duke Molecular Physiology Institute

Medicine, Nephrology

Psychiatry & Behavioral Sciences, Behavioral Medicine

Psychiatry & Behavioral Sciences

Published

9