MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.
dc.contributor.author | Wang, Meng-Yun | |
dc.contributor.author | Jia, Ming | |
dc.contributor.author | He, Jing | |
dc.contributor.author | Zhou, Fei | |
dc.contributor.author | Qiu, Li-Xin | |
dc.contributor.author | Sun, Meng-Hong | |
dc.contributor.author | Yang, Ya-Jun | |
dc.contributor.author | Wang, Jiu-Cun | |
dc.contributor.author | Jin, Li | |
dc.contributor.author | Wang, Ya-Nong | |
dc.contributor.author | Wei, Qing-Yi | |
dc.date.accessioned | 2021-07-08T15:54:15Z | |
dc.date.available | 2021-07-08T15:54:15Z | |
dc.date.issued | 2017-03 | |
dc.date.updated | 2021-07-08T15:54:13Z | |
dc.description.abstract | MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G and rs10900598 G>T) in MDM4 and gastric cancer risk in an Eastern Chinese Population. In logistic regression analysis, a significantly decreased GCa risk was associated with the rs1380576 GG variant genotype (adjusted odds ratio [OR] =0.74, 95% confidence interval [CI] =0.56-0.98) under a recessive model, which remained significant after correction by the false-positive reporting probability. This risk was more evident in subgroups of older subjects, males, never smokers, never drinkers and cancers of non-cardia. We then performed SNP-mRNA expression correlation analysis and found that the GG variant genotype was associated with significantly decreased expression of MDM4 mRNA in normal cell lines for 44 Chinese (P=0.032 for GG vs. CC) as well as for 269 multi-ethnic subjects (P<0.0001 for GG vs. CC). Our results suggest that the MDM4 rs1380576 G variant may be markers for GCa susceptibility. Larger, independent studies are warranted to validate our findings. | |
dc.identifier | 14666 | |
dc.identifier.issn | 1949-2553 | |
dc.identifier.issn | 1949-2553 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Impact Journals, LLC | |
dc.relation.ispartof | Oncotarget | |
dc.relation.isversionof | 10.18632/oncotarget.14666 | |
dc.subject | Humans | |
dc.subject | Stomach Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Cell Cycle Proteins | |
dc.subject | Proto-Oncogene Proteins | |
dc.subject | Nuclear Proteins | |
dc.subject | RNA, Messenger | |
dc.subject | Neoplasm Staging | |
dc.subject | Prognosis | |
dc.subject | Survival Rate | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Longitudinal Studies | |
dc.subject | Follow-Up Studies | |
dc.subject | Prospective Studies | |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | |
dc.subject | Genotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | China | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Real-Time Polymerase Chain Reaction | |
dc.subject | Biomarkers, Tumor | |
dc.title | MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population. | |
dc.type | Journal article | |
duke.contributor.orcid | Wei, Qing-Yi|0000-0002-3845-9445|0000-0003-4115-4439 | |
pubs.begin-page | 19547 | |
pubs.end-page | 19555 | |
pubs.issue | 12 | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Population Health Sciences | |
pubs.organisational-group | Duke Global Health Institute | |
pubs.organisational-group | Medicine, Medical Oncology | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.publication-status | Published | |
pubs.volume | 8 |
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