MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.

dc.contributor.author

Wang, Meng-Yun

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Jia, Ming

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He, Jing

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Zhou, Fei

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Qiu, Li-Xin

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Sun, Meng-Hong

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Yang, Ya-Jun

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Wang, Jiu-Cun

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Jin, Li

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Wang, Ya-Nong

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Wei, Qing-Yi

dc.date.accessioned

2021-07-08T15:54:15Z

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2021-07-08T15:54:15Z

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2017-03

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2021-07-08T15:54:13Z

dc.description.abstract

MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G and rs10900598 G>T) in MDM4 and gastric cancer risk in an Eastern Chinese Population. In logistic regression analysis, a significantly decreased GCa risk was associated with the rs1380576 GG variant genotype (adjusted odds ratio [OR] =0.74, 95% confidence interval [CI] =0.56-0.98) under a recessive model, which remained significant after correction by the false-positive reporting probability. This risk was more evident in subgroups of older subjects, males, never smokers, never drinkers and cancers of non-cardia. We then performed SNP-mRNA expression correlation analysis and found that the GG variant genotype was associated with significantly decreased expression of MDM4 mRNA in normal cell lines for 44 Chinese (P=0.032 for GG vs. CC) as well as for 269 multi-ethnic subjects (P<0.0001 for GG vs. CC). Our results suggest that the MDM4 rs1380576 G variant may be markers for GCa susceptibility. Larger, independent studies are warranted to validate our findings.

dc.identifier

14666

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1949-2553

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1949-2553

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https://hdl.handle.net/10161/23443

dc.language

eng

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Impact Journals, LLC

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Oncotarget

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10.18632/oncotarget.14666

dc.subject

Humans

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Stomach Neoplasms

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Genetic Predisposition to Disease

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Cell Cycle Proteins

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Proto-Oncogene Proteins

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Nuclear Proteins

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RNA, Messenger

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Neoplasm Staging

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Prognosis

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Survival Rate

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Risk Factors

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Case-Control Studies

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Longitudinal Studies

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Follow-Up Studies

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Prospective Studies

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Reverse Transcriptase Polymerase Chain Reaction

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Genotype

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Polymorphism, Single Nucleotide

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Adult

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Aged

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Aged, 80 and over

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Middle Aged

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China

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Female

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Male

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Young Adult

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Real-Time Polymerase Chain Reaction

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Biomarkers, Tumor

dc.title

MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.

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Journal article

duke.contributor.orcid

Wei, Qing-Yi|0000-0002-3845-9445|0000-0003-4115-4439

pubs.begin-page

19547

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19555

pubs.issue

12

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School of Medicine

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Duke Cancer Institute

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Population Health Sciences

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Duke Global Health Institute

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Medicine, Medical Oncology

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Duke

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Institutes and Centers

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Basic Science Departments

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Medicine

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Clinical Science Departments

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Published

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8

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