Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.

van den Berg, Stéphanie M

de Moor, Marleen HM

McGue, Matt

Pettersson, Erik

Terracciano, Antonio

Verweij, Karin JH

Amin, Najaf

Derringer, Jaime

Esko, Tõnu

van Grootheest, Gerard

Hansell, Narelle K

Huffman, Jennifer

Konte, Bettina

Lahti, Jari

Luciano, Michelle

Matteson, Lindsay K

Viktorin, Alexander

Wouda, Jasper

Agrawal, Arpana

Allik, Jüri

Bierut, Laura

Broms, Ulla

Campbell, Harry

Smith, George Davey

Eriksson, Johan G

Ferrucci, Luigi

Franke, Barbera

Fox, Jean-Paul

de Geus, Eco JC

Giegling, Ina

Gow, Alan J

Grucza, Richard

Hartmann, Annette M

Heath, Andrew C

Heikkilä, Kauko

Iacono, William G

Janzing, Joost

Jokela, Markus

Kiemeney, Lambertus

Lehtimäki, Terho

Madden, Pamela AF

Magnusson, Patrik KE

Northstone, Kate

Nutile, Teresa

Ouwens, Klaasjan G

Palotie, Aarno

Pattie, Alison

Pesonen, Anu-Katriina

Polasek, Ozren

Pulkkinen, Lea

Pulkki-Råback, Laura

Raitakari, Olli T

Realo, Anu

Rose, Richard J

Ruggiero, Daniela

Seppälä, Ilkka

Slutske, Wendy S

Smyth, David C

Sorice, Rossella

Starr, John M

Sutin, Angelina R

Tanaka, Toshiko

Verhagen, Josine

Vermeulen, Sita

Vuoksimaa, Eero

Widen, Elisabeth

Willemsen, Gonneke

Wright, Margaret J

Zgaga, Lina

Rujescu, Dan

Metspalu, Andres

Wilson, James F

Ciullo, Marina

Hayward, Caroline

Rudan, Igor

Deary, Ian J

Räikkönen, Katri

Arias Vasquez, Alejandro

Costa, Paul T

Keltikangas-Järvinen, Liisa

van Duijn, Cornelia M

Penninx, Brenda WJH

Krueger, Robert F

Evans, David M

Kaprio, Jaakko

Pedersen, Nancy L

Martin, Nicholas G

Boomsma, Dorret I

2021-05-03T20:33:46Z

2021-05-03T20:33:46Z

2014-07

2021-05-03T20:33:44Z

Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.

0001-8244

1573-3297

https://hdl.handle.net/10161/22753

eng

Springer Science and Business Media LLC

Behavior genetics

10.1007/s10519-014-9654-x

Humans

Models, Statistical

Personality

Anxiety Disorders

Personality Assessment

Phenotype

Genome-Wide Association Study

Neuroticism

Extraversion, Psychological

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.

Journal article

Costa, Paul T|0000-0003-4375-1712

295

313

4

School of Medicine

Psychiatry & Behavioral Sciences, Behavioral Medicine

Duke

Psychiatry & Behavioral Sciences

Clinical Science Departments

Published

44