Browsing by Subject "microneedle"
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Item Open Access Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation.(International journal of bioprinting, 2017-01) Sachan, Roger; Jaipan, Panupong; Zhang, Jennifer Y; Degan, Simone; Erdmann, Detlev; Tedesco, Jonathan; Vanderwal, Lyndsi; Stafslien, Shane J; Negut, Irina; Visan, Anita; Dorcioman, Gabriela; Socol, Gabriel; Cristescu, Rodica; Chrisey, Douglas B; Narayan, Roger JTransdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles.