Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation.


Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles.





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Publication Info

Sachan, Roger, Panupong Jaipan, Jennifer Y Zhang, Simone Degan, Detlev Erdmann, Jonathan Tedesco, Lyndsi Vanderwal, Shane J Stafslien, et al. (2017). Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation. International journal of bioprinting, 3(2). p. 004. 10.18063/ijb.2017.02.004 Retrieved from

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