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  • ItemOpen Access
  • ItemOpen Access
    Renewal and Accoglienza in Tasso’s Rome
    (California Italian Studies) Driscoll, Kate
  • ItemOpen Access
    Detection of small microplastics in the surface freshwater samples of Yangcheng Lake, China
    (Heliyon, 2024-11) Xu, Zhenyu; Earnhardt, Natalie; Kotsifaki, Domna G
  • ItemOpen Access
    Margie Gillis: The indelible art of an integrated artist
    (Dance Chronicle, 2018-05-04) Dickinson, B
    This article examines the life and work of Canadian choreographer and performer Margie Gillis, identifying her as an integrated artist and considering her work through perspectives from artists, cognitive scientists, Tibetan Buddhists, and individuals in the medical field who have explored the concept of nonlocality. The essay examines Gillis’s ability to create strong connections between the audience and herself as performer, and posits that this bond results from Gillis’s strongly communicated visual, physical, intellectual, spiritual, and emotional aspects. The artists interviewed and referenced in this paper are Irene Dowd, Risa Steinberg, and, predominantly, Margie Gillis.
  • ItemOpen Access
    PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling.
    (Nucleic acids research, 2024-10) Yang, Yang; Jayaprakash, Deepika; Jhujh, Satpal S; Reynolds, John J; Chen, Steve; Gao, Yanzhe; Anand, Jay Ramanlal; Mutter-Rottmayer, Elizabeth; Ariel, Pablo; An, Jing; Cheng, Xing; Pearce, Kenneth H; Blanchet, Sophie-Anne; Nandakumar, Nandana; Zhou, Pei; Fradet-Turcotte, Amélie; Stewart, Grant S; Vaziri, Cyrus
    RNF168 orchestrates a ubiquitin-dependent DNA damage response to regulate the recruitment of repair factors, such as 53BP1 to DNA double-strand breaks (DSBs). In addition to its canonical functions in DSB signaling, RNF168 may facilitate DNA replication fork progression. However, the precise role of RNF168 in DNA replication remains unclear. Here, we demonstrate that RNF168 is recruited to DNA replication factories in a manner that is independent of the canonical DSB response pathway regulated by Ataxia-Telangiectasia Mutated (ATM) and RNF8. We identify a degenerate Proliferating Cell Nuclear Antigen (PCNA)-interacting peptide (DPIP) motif in the C-terminus of RNF168, which together with its Motif Interacting with Ubiquitin (MIU) domain mediates binding to mono-ubiquitylated PCNA at replication factories. An RNF168 mutant harboring inactivating substitutions in its DPIP box and MIU1 domain (termed RNF168 ΔDPIP/ΔMIU1) is not recruited to sites of DNA synthesis and fails to support ongoing DNA replication. Notably, the PCNA interaction-deficient RNF168 ΔDPIP/ΔMIU1 mutant fully rescues the ability of RNF168-/- cells to form 53BP1 foci in response to DNA DSBs. Therefore, RNF168 functions in DNA replication and DSB signaling are fully separable. Our results define a new mechanism by which RNF168 promotes DNA replication independently of its canonical functions in DSB signaling.
  • ItemOpen Access
    Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
    (Scientific Reports, 2024-12-01) Giles, E; Heifets, A; Artía, Z; Inde, Z; Liu, Z; Zhang, Z; Wang, Z; Su, Z; Chung, Z; Frangos, ZJ; Li, Y; Yen, Y; Sidorova, YA; Tse-Dinh, YC; He, Y; Tang, Y; Li, Y; Pérez-Pertejo, Y; Gupta, YK; Zhu, Y; Sun, Y; Li, Y; Chen, Y; Aldhamen, YA; Hu, Y; Zhang, YJ; Zhang, X; Yuan, X; Wang, X; Qin, X; Yu, X; Xu, X; Qi, X; Lu, X; Wu, X; Blanchet, X; Foong, WE; Bradshaw, WJ; Gerwick, WH; Kerr, WG; Hahn, WC; Donaldson, WA; Van Voorhis, WC; Zhang, W; Tang, W; Li, W; Houry, WA; Lowther, WT; Clayton, WB; Van Hung Le, V; Ronchi, VP; Woods, VA; Scoffone, VC; Maltarollo, VG; Dolce, V; Maranda, V; Segers, VFM; Namasivayam, V; Gunasekharan, V; Robinson, VL; Banerji, V; Tandon, V; Thai, VC; Pai, VP; Desai, UR; Baumann, U; Chou, TF; Chou, T; O’Mara, TA; Banjo, T; Su, T; Lan, T; Ogunwa, TH; Hermle, T; Corson, TW; O’Meara, TR; Kotzé, TJ; Herdendorf, TJ; Richardson, TI; Kampourakis, T; Gillingwater, TH; Jayasinghe, TD; Teixeira, TR; Ikegami, T; Moreda, TL; Haikarainen, T; Akopian, T; Abaffy, T; Swart, T; Mehlman, T; Teramoto, T; Azeem, SM; Dallman, S; Brady-Kalnay, SM; Sarilla, S; Van Doren, SR; Marx, SO; Olson, SH; Poirier, S; Waggoner, SN
    Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-54655-z, published online 02 April 2024 The original version of this Article contained errors. In the original version of this article, Ellie Giles was omitted from the Author list. Additionally, the following Affiliation information has been updated: 1. Affiliation 25 was incorrect. Affiliation 25 ‘Queensland University of Technology, Brisbane, USA.’ now reads, ‘Queensland University of Technology, Brisbane, Australia.’ 2. Marta Giorgis was incorrectly affiliated with the ‘University of Aberdeen, Aberdeen, UK.’ The correct Affiliation is listed below: ‘University of Turin, Turin, Italy.’ 3. Affiliations 52, 125 and 261 were duplicated. As a result, the correct Affiliation for Andrew B. Herr, Benjamin Liou, David A. Hildeman, Joseph J. Maciag, Ying Sun, Durga Krishnamurthy, and Stephen N. Waggoner is: ‘Cincinnati Children’s Hospital Medical Center, Cincinnati, USA.’ Furthermore, an outdated version of Figure 1 was typeset. The original Figure 1 and accompanying legend appear below. (Figure presented.) Pairs of representative compounds extracted from AI patents (right) and corresponding prior patents (left) for clinical-stage programs (CDK792,93, A2Ar-antagonist94,95, MALT196,97, QPCTL98,99, USP1100,101, and 3CLpro102,103). The identical atoms between the chemical structures are highlighted in red. Lastly, The Acknowledgements section contained an error. “See Supplementary section S1.” now reads, “See Supplementary section S2.” The original Article has been corrected.
  • ItemOpen Access
    Bryospheres in oligotrophic headwater streams provide nutrient-dense habitats and dominate stream nutrient cycling
    (Freshwater Science, 2024) Steele, Jessee JB; Thellman, Audrey N; Vought, Olivia K; Rosi, Emma J; Wooster, Tammy; Solomon, Christopher T; Bernhardt, Emily S
  • ItemOpen Access
    Differential Mnemonic Contributions of Cortical Representations during Encoding and Retrieval.
    (Journal of cognitive neuroscience, 2024-10) Howard, Cortney M; Huang, Shenyang; Hovhannisyan, Mariam; Cabeza, Roberto; Davis, Simon W
    Several recent fMRI studies of episodic and working memory representations converge on the finding that visual information is most strongly represented in occipito-temporal cortex during the encoding phase but in parietal regions during the retrieval phase. It has been suggested that this location shift reflects a change in the content of representations, from predominantly visual during encoding to primarily semantic during retrieval. Yet, direct evidence on the nature of encoding and retrieval representations is lacking. It is also unclear how the representations mediating the encoding-retrieval shift contribute to memory performance. To investigate these two issues, in the current fMRI study, participants encoded pictures (e.g., picture of a cardinal) and later performed a word recognition test (e.g., word "cardinal"). Representational similarity analyses examined how visual (e.g., red color) and semantic representations (e.g., what cardinals eat) support successful encoding and retrieval. These analyses revealed two novel findings. First, successful memory was associated with representational changes in cortical location (from occipito-temporal at encoding to parietal at retrieval) but not with changes in representational content (visual vs. semantic). Thus, the representational encoding-retrieval shift cannot be easily attributed to a change in the nature of representations. Second, in parietal regions, stronger representations predicted encoding failure but retrieval success. This encoding-retrieval "flip" in representations mimics the one previously reported in univariate activation studies. In summary, by answering important questions regarding the content and contributions to the performance of the representations mediating the encoding-retrieval shift, our findings clarify the neural mechanisms of this intriguing phenomenon.
  • ItemOpen Access
    Neurotoxicology and Public Health Issues of Cannabis and Cannabinoids.
    (Neurotoxicology, 2024-10) Leung, Maxwell CK; Levin, Edward D
  • ItemOpen Access
    Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.
    (bioRxiv, 2024-09-10) Cammarata, Celine M; Pei, Yingming; Shields, Brenda C; Lim, Shaun SX; Hawley, Tammy; Li, Jennifer Y; St Amand, David; Brunel, Nicolas; Tadross, Michael R; Glickfeld, Lindsey L
    Inhibition stabilization enables cortical circuits to encode sensory signals across diverse contexts. Somatostatin-expressing (SST) interneurons are well-suited for this role through their strong recurrent connectivity with excitatory pyramidal cells. We developed a cortical circuit model predicting that SST cells become increasingly important for stabilization as sensory input strengthens. We tested this prediction in mouse primary visual cortex by manipulating excitatory input to SST cells, a key parameter for inhibition stabilization, with a novel cell-type specific pharmacological method to selectively block glutamatergic receptors on SST cells. Consistent with our model predictions, we find antagonizing glutamatergic receptors drives a paradoxical facilitation of SST cells with increasing stimulus contrast. In addition, we find even stronger engagement of SST-dependent stabilization when the mice are aroused. Thus, we reveal that the role of SST cells in cortical processing gradually switches as a function of both input strength and behavioral state.
  • ItemOpen Access
    Demographic History and English Culture
    (Journal of Medieval and Early Modern Studies, 2024-09-01) Werlin, J
    In England, the period from the late Middle Ages through early modernity was bookended by demographic change. On one edge, there was the Black Death and subsequent plague pandemics, which halved the population, reshaping English society in their wake. On the other, there was the demographic transition of the mid-eighteenth century, which reduced death rates and led to modern family structures. Between these two epochal events, demographic trends shaped English customs and values, and were in turn shaped by them. The articles in this special issue draw on cutting-edge demographic research to offer new interpretations of the effects of plague, patterns of marriage, evolving forms of labor, and the morality of crime and charity, among other subjects. Together, they illustrate how quantitative studies in historical demography can shed light on key transformations in culture and society—and vice versa.
  • ItemOpen Access
    Challenges to Improving Palliative Care and the Role of an Anesthesiologist
    (ASA Monitor, 2024-11-01) Karnati, Rohit; Yi, Peter; Anwar, Muhammad A Farooq
  • ItemOpen Access
    Let the Music Play: Live Music Fosters Collective Effervescence and Leads to Lasting Positive Outcomes.
    (Personality & social psychology bulletin, 2024-10) Koefler, Nicole; Naidu, Esha; Gabriel, Shira; Schneider, Veronica; Pascuzzi, Gabriela S; Paravati, Elaine
    This work examined the power of live music events to enhance wellbeing through collective effervescence (CE)-the sense of sacredness and connection felt when in large groups. Four studies (N = 789) using both university and community samples examined the relationship between live music events and CE and how this relationship contributes to positive, lasting outcomes. Results suggest that CE is highly related to positive outcomes associated with attending live music events. CE uniquely predicted meaning in life and enjoyment during the event above and beyond related constructs. Feeling CE was also related to greater meaning in life during the event and continued happiness a week after live music events. Further, CE mediated effects between various elements of live music events (e.g., parasocial bonds with the artist) and positive lasting outcomes. In summary, CE plays a key role in the lasting wellbeing that follows live music events.
  • ItemOpen Access
    2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
    (Journal of the American College of Cardiology, 2024-09) Writing Committee Members; Thompson, Annemarie; Fleischmann, Kirsten E; Smilowitz, Nathaniel R; de Las Fuentes, Lisa; Mukherjee, Debabrata; Aggarwal, Niti R; Ahmad, Faraz S; Allen, Robert B; Altin, S Elissa; Auerbach, Andrew; Berger, Jeffrey S; Chow, Benjamin; Dakik, Habib A; Eisenstein, Eric L; Gerhard-Herman, Marie; Ghadimi, Kamrouz; Kachulis, Bessie; Leclerc, Jacinthe; Lee, Christopher S; Macaulay, Tracy E; Mates, Gail; Merli, Geno J; Parwani, Purvi; Poole, Jeanne E; Rich, Michael W; Ruetzler, Kurt; Stain, Steven C; Sweitzer, BobbieJean; Talbot, Amy W; Vallabhajosyula, Saraschandra; Whittle, John; Williams, Kim Allan

    Aim

    The "2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery" provides recommendations to guide clinicians in the perioperative cardiovascular evaluation and management of adult patients undergoing noncardiac surgery.

    Methods

    A comprehensive literature search was conducted from August 2022 to March 2023 to identify clinical studies, reviews, and other evidence conducted on human subjects that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline.

    Structure

    Recommendations from the "2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery" have been updated with new evidence consolidated to guide clinicians; clinicians should be advised this guideline supersedes the previously published 2014 guideline. In addition, evidence-based management strategies, including pharmacological therapies, perioperative monitoring, and devices, for cardiovascular disease and associated medical conditions, have been developed.
  • ItemOpen Access
    ERAS/STS 2024 Expert Consensus Statement on Perioperative Care in Cardiac Surgery: Continuing the Evolution of Optimized Patient Care and Recovery.
    (Journal of cardiothoracic and vascular anesthesia, 2024-10) Gregory, Alexander; Ender, Joerg; Shaw, Andrew D; Denault, André; Ibekwe, Stephanie; Stoppe, Christian; Alli, Ahmad; Manning, Michael W; Brodt, Jessica L; Galhardo, Carlos; Sander, Michael; Zarbock, Alexander; Fletcher, Nick; Ghadimi, Kamrouz; Grant, Michael C
  • ItemOpen Access
    Heart failure diagnostic accuracy, intraoperative fluid management, and postoperative acute kidney injury: a single-centre prospective observational study.
    (British journal of anaesthesia, 2024-10) Mathis, Michael R; Ghadimi, Kamrouz; Benner, Andrew; Jewell, Elizabeth S; Janda, Allison M; Joo, Hyeon; Maile, Michael D; Golbus, Jessica R; Aaronson, Keith D; Engoren, Milo C; Michigan Congestive Heart Failure Investigators

    Background

    The accurate diagnosis of heart failure (HF) before major noncardiac surgery is frequently challenging. The impact of diagnostic accuracy for HF on intraoperative practice patterns and clinical outcomes remains unknown.

    Methods

    We performed an observational study of adult patients undergoing major noncardiac surgery at an academic hospital from 2015 to 2019. A preoperative clinical diagnosis of HF was defined by keywords in the preoperative assessment or a diagnosis code. Medical records of patients with and without HF clinical diagnoses were reviewed by a multispecialty panel of physician experts to develop an adjudicated HF reference standard. The exposure of interest was an adjudicated diagnosis of heart failure. The primary outcome was volume of intraoperative fluid administered. The secondary outcome was postoperative acute kidney injury (AKI).

    Results

    From 40 659 surgeries, a stratified subsample of 1018 patients were reviewed by a physician panel. Among patients with adjudicated diagnoses of HF, those without a clinical diagnosis (false negatives) more commonly had preserved left ventricular ejection fractions and fewer comorbidities. Compared with false negatives, an accurate diagnosis of HF (true positives) was associated with 470 ml (95% confidence interval: 120-830; P=0.009) lower intraoperative fluid administration and lower risk of AKI (adjusted odds ratio:0.39, 95% confidence interval 0.18-0.89). For patients without adjudicated diagnoses of HF, non-HF was not associated with differences in either fluids administered or AKI.

    Conclusions

    An accurate preoperative diagnosis of heart failure before noncardiac surgery is associated with reduced intraoperative fluid administration and less acute kidney injury. Targeted efforts to improve preoperative diagnostic accuracy for heart failure may improve perioperative outcomes.
  • ItemOpen Access
    Overcoming Challenges to Research Success in Cardiothoracic Anesthesiology Fellowship Training.
    (Journal of cardiothoracic and vascular anesthesia, 2024-10) Bottiger, Brandi A; Ghadimi, Kamrouz; Cherry, Anne; Mazzeffi, Michael
  • ItemOpen Access
    Intraoperative fluid management in adult spinal deformity surgery: variation analysis and association with outcomes
    (Spine Deformity, 2024-01-01) Cetik, RM; Gum, JL; Lafage, R; Smith, JS; Bess, S; Mullin, JP; Kelly, MP; Diebo, BG; Buell, TJ; Scheer, JK; Line, BG; Lafage, V; Klineberg, EO; Kim, HJ; Passias, PG; Kebaish, KM; Eastlack, RK; Daniels, AH; Soroceanu, A; Mundis, GM; Hostin, RA; Protopsaltis, TS; Hamilton, DK; Hart, RA; Gupta, MC; Lewis, SJ; Schwab, FJ; Lenke, LG; Shaffrey, CI; Ames, CP; Burton, DC
    Purpose: To evaluate the variability in intraoperative fluid management during adult spinal deformity (ASD) surgery, and analyze the association with complications, intensive care unit (ICU) requirement, and length of hospital stay (LOS). Methods: Multicenter comparative cohort study. Patients ≥ 18 years old and with ASD were included. Intraoperative intravenous (IV) fluid data were collected including: crystalloids, colloids, crystalloid/colloid ratio (C/C), total IV fluid (tIVF, ml), normalized total IV fluid (nIVF, ml/kg/h), input/output ratio (IOR), input–output difference (IOD), and normalized input–output difference (nIOD, ml/kg/h). Data from different centers were compared for variability analysis, and fluid parameters were analyzed for possible associations with the outcomes. Results: Seven hundred ninety-eight patients with a median age of 65.2 were included. Among different surgical centers, tIVF, nIVF, and C/C showed significant variation (p < 0.001 for each) with differences of 4.8-fold, 3.7-fold, and 4.9-fold, respectively. Two hundred ninety-two (36.6%) patients experienced at least one in-hospital complication, and ninety-two (11.5%) were IV fluid related. Univariate analysis showed significant relations for: LOS and tIVF (ρ = 0.221, p < 0.001), IOD (ρ = 0.115, p = 0.001) and IOR (ρ = −0.138, p < 0.001); IV fluid-related complications and tIVF (p = 0.049); ICU stay and tIVF, nIVF, IOD and nIOD (p < 0.001 each); extended ICU stay and tIVF (p < 0.001), nIVF (p = 0.010) and IOD (p < 0.001). Multivariate analysis controlling for confounders showed significant relations for: LOS and tIVF (p < 0.001) and nIVF (p = 0.003); ICU stay and IOR (p = 0.002), extended ICU stay and tIVF (p = 0.004). Conclusion: Significant variability and lack of standardization in intraoperative IV fluid management exists between different surgical centers. Excessive fluid administration was found to be correlated with negative outcomes. Level of evidence: III.
  • ItemOpen Access
    Impact of Prior Cervical Fusion on Patients Undergoing Thoracolumbar Deformity Correction.
    (Spine, 2024-08) Singh, Manjot; Balmaceno-Criss, Mariah; Daher, Mohammad; Lafage, Renaud; Eastlack, Robert K; Gupta, Munish C; Mundis, Gregory M; Gum, Jeffrey L; Hamilton, Kojo D; Hostin, Richard; Passias, Peter G; Protopsaltis, Themistocles S; Kebaish, Khaled M; Lenke, Lawrence G; Ames, Christopher P; Burton, Douglas C; Lewis, Stephen M; Klineberg, Eric O; Kim, Han Jo; Schwab, Frank J; Shaffrey, Christopher I; Smith, Justin S; Line, Breton G; Bess, Shay; Lafage, Virginie; Diebo, Bassel G; Daniels, Alan H; ISSG

    Study design

    Retrospective analysis of prospectively collected data.

    Objective

    Evaluate the impact of prior cervical constructs on upper instrumented vertebrae (UIV) selection and postoperative outcomes among patients undergoing thoracolumbar deformity correction.

    Background

    Surgical planning for adult spinal deformity (ASD) patients involves consideration of spinal alignment and existing fusion constructs.

    Methods

    ASD patients with (ANTERIOR or POSTERIOR) and without (NONE) prior cervical fusion who underwent thoracolumbar fusion were included. Demographics, radiographic alignment, patient-reported outcome measures (PROMs), and complications were compared. Univariate and multivariate analyses were performed on POSTERIOR patients to identify parameters predictive of UIV choice and to evaluate postoperative outcomes impacted by UIV selection.

    Results

    Among 542 patients, with 446 NONE, 72 ANTERIOR, and 24 POSTERIOR patients, mean age was 64.4 years and 432 (80%) were female. Cervical fusion patients had worse preoperative cervical and lumbosacral deformity, and PROMs (P<0.05). In the POSTERIOR cohort, preoperative LIV was frequently below the cervicothoracic junction (54%) and uncommonly (13%) connected to the thoracolumbar UIV. Multivariate analyses revealed that higher preoperative cervical SVA (coeff=-0.22, 95%CI=-0.43--0.01, P=0.038) and C2SPi (coeff=-0.72, 95%CI=-1.36--0.07, P=0.031), and lower preoperative thoracic kyphosis (coeff=0.14, 95%CI=0.01-0.28, P=0.040) and thoracolumbar lordosis (coeff=0.22, 95%CI=0.10-0.33, P=0.001) were predictive of cranial UIV. Two-year postoperatively, cervical patients continued to have worse cervical deformity and PROMs (P<0.05) but had comparable postoperative complications. Choice of thoracolumbar UIV below or above T6, as well as the number of unfused levels between constructs, did not affect patient outcomes.

    Conclusions

    Among patients who underwent thoracolumbar deformity correction, prior cervical fusion was associated with more severe spinopelvic deformity and PROMs preoperatively. The choice of thoracolumbar UIV was strongly predicted by their baseline cervical and thoracolumbar alignment. Despite their poor preoperative condition, these patients still experienced significant improvements in their thoracolumbar alignment and PROMs after surgery, irrespective of UIV selection.

    Level of evidence

    IV.
  • ItemOpen Access
    Does comorbid depression and anxiety portend poor long-term outcomes following surgery for lumbar spondylolisthesis? Five-year analysis of the Quality Outcomes Database.
    (Journal of neurosurgery. Spine, 2024-09) DiDomenico, Joseph; Farber, S Harrison; Virk, Michael S; Godzik, Jakub; Johnson, Sarah E; Bydon, Mohamad; Mummaneni, Praveen V; Bisson, Erica F; Glassman, Steven D; Chan, Andrew K; Chou, Dean; Fu, Kai-Ming; Shaffrey, Christopher I; Asher, Anthony L; Coric, Domagoj; Potts, Eric A; Foley, Kevin T; Wang, Michael Y; Knightly, John J; Park, Paul; Shaffrey, Mark E; Slotkin, Jonathan R; Haid, Regis W; Uribe, Juan S; Turner, Jay D

    Objective

    Depression and anxiety are associated with poor outcomes following spine surgery. However, the influence of these conditions on achieving a minimal clinically important difference (MCID) following lumbar spine surgery, as well as the potential compounding effects of comorbid depression and anxiety, is not well understood. This study explores the impact of comorbid depression and anxiety on long-term clinical outcomes following surgical treatment for degenerative lumbar spondylolisthesis.

    Methods

    This study was a retrospective analysis of the multicenter, prospectively collected Quality Outcomes Database (QOD). Patients with surgically treated grade 1 lumbar spondylolisthesis from 12 centers were included. Preoperative baseline characteristics and comorbidities were recorded, including self-reported depression and/or anxiety. Pre- and postoperative patient-reported outcomes (PROs) were recorded: the numeric rating scale (NRS) score for back pain (NRS-BP), NRS score for leg pain (NRS-LP), Oswestry Disability Index (ODI), and EQ-5D. Patients were grouped into 3 cohorts: no self-reported depression or anxiety (non-SRD/A), self-reported depression or anxiety (SRD/A), or presence of both comorbidities (SRD+A). Changes in PROs over time, satisfaction rates, and rates of MCID were compared. A multivariable regression analysis was performed to establish independent associations.

    Results

    Of the 608 patients, there were 452 (74.3%) with non-SRD/A, 81 (13.3%) with SRD/A, and 75 (12.3%) with SRD+A. Overall, 91.8% and 80.4% of patients had ≥ 24 and ≥ 60 months of follow-up, respectively. Baseline PROs were universally inferior for the SRD+A cohort. However, at 60-month follow-up, changes in all PROs were greatest for the SRD+A cohort, resulting in nonsignificant differences in absolute NRS-BP, NRS-LP, ODI, and EQ-5D across the 3 groups. MCID was achieved for the SRD+A cohort at similar rates to the non-SRD/A cohort. All groups achieved > 80% satisfaction rates with surgery without significant differences across the cohorts (p = 0.79). On multivariable regression, comorbid depression and anxiety were associated with worse baseline PROs, but they had no impact on 60-month PROs or 60-month achievement of MCIDs.

    Conclusions

    Despite lower baseline PROs, patients with comorbid depression and anxiety achieved comparable rates of MCID and satisfaction after surgery for lumbar spondylolisthesis to those without either condition. This quality-of-life benefit was durable at 5-year follow-up. These data suggest that patients with self-reported comorbid depression and anxiety should not be excluded from consideration of surgical intervention and often substantially benefit from surgery.

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