Scholarly Articles
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Item type: Item , Access status: Open Access , Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.(Cancer cell, 2024-06) Finlay, John B; Ireland, Abbie S; Hawgood, Sarah B; Reyes, Tony; Ko, Tiffany; Olsen, Rachelle R; Abi Hachem, Ralph; Jang, David W; Bell, Diana; Chan, Joseph M; Goldstein, Bradley J; Oliver, Trudy GThe olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse model of high-grade metastatic ONB exhibiting a NEUROD1+ immature neuronal phenotype. We demonstrate that globose basal cells (GBCs) are a permissive cell of origin for ONB and that ONBs exhibit cell fate heterogeneity that mimics normal GBC developmental trajectories. ASCL1 loss in RPM ONB leads to emergence of non-neuronal histopathologies, including a POU2F3+ microvillar-like state. Similar to small-cell lung cancer (SCLC), mouse and human ONBs exhibit mutually exclusive NEUROD1 and POU2F3-like states, an immune-cold tumor microenvironment, intratumoral cell fate heterogeneity comprising neuronal and non-neuronal lineages, and cell fate plasticity-evidenced by barcode-based lineage tracing and single-cell transcriptomics. Collectively, our findings highlight conserved similarities between ONB and neuroendocrine tumors with significant implications for ONB classification and treatment.Item type: Item , Access status: Open Access , Impact of HIV Status on Fruit and Vegetable Consumption Among Older Adults in Tanzania: A Cross-Sectional Data Analysis(2025-12-24) Mosha, Mary; Paulo, Heavenlight; Ayodele, Victoria Temitayo; Wajanga, Bahati; Perry, Mirlene; Muiruri, CharlesItem type: Item , Access status: Open Access , Expanding healthcare access in rural sub-Saharan Africa.(Perspectives in public health, 2024-11) Anand, S; Ayodele, V; Ashraf, A; Shilleh, MA; Rahim, FO; Mmbaga, BT; Rugakingira, AWhile healthcare delivery in sub-Saharan Africa (SSA) has made notable strides, the benefits of improved access predominantly favour urban areas, leaving rural communities largely underserved. A multitude of barriers contribute to this disparity, including inadequate funding, a shortage of trained medical professionals, insufficient transportation, underdeveloped infrastructure, and entrenched educational and cultural beliefs. As rural SSA populations grapple with escalating burdens in infectious diseases such as HIV, malaria, tuberculosis, and heightened risks during childbirth and pregnancy, it becomes imperative to confront these obstacles in healthcare delivery and enhance healthcare provision in these regions.Item type: Item , Access status: Open Access , Scaling back aid for Africa is a strategic misstep for the United States(Global Security Health Science and Policy, 2025-01-01) Rahim, FO; Haque, H; Karthik, R; Ayodele, V; Beyrer, C; Bekele, APolicy shifts in US foreign aid under the Trump administration have had far-reaching consequences for global health, particularly on the African continent. The withdrawal from the World Health Organization and the suspension of foreign aid have significantly disrupted US global health initiatives. While programmes such as PEPFAR have retained some support, the shutdown on USAID operations–a critical agency for health and disease response across 47 sub-Saharan African countries–poses substantial challenges. These cutbacks not only threaten public health efforts but also diminish strategic investment opportunities, given Africa’s rapidly growing economies and potential for high economic returns. Furthermore, reducing aid endangers healthcare and biomedical innovations that have been instrumental in combating diseases such as Ebola and HIV. In the past, US-funded initiatives have contributed to Africa’s pharmaceutical manufacturing capacity and technological advancements, fostering mutual economic benefits. The shift in foreign aid policy risks weakening US global influence, creating a vacuum that geopolitical competitors, such as China and Russia, are poised to exploit. In this paper, we argue that sustained investment in African health initiatives is essential for strengthening economic partnerships, enhancing global health security, and reinforcing US geopolitical standing.Item type: Item , Access status: Open Access , The Evolution and Impact of the Nasal Positive Pressure Oxygenation Device (SuperNO2VA™) in Modern Anesthesia.(Cureus, 2025-07) Zhitny, Vladislav P; Dixon, Brett; Jannoud, Ryan; Sills, Joelle; Carillo, Ariana R; Wajda, Michael C; Primm, Aaron N; Mendelson, BrianThe nasal positive pressure oxygenation device, SuperNO2VA™ (Vyaire Medical™), represents a significant advancement in airway management and perioperative care, particularly in patients at high risk for hypoxemia. This paper traces the historical development, underlying technology, and clinical adoption of the device, emphasizing its role in improving patient outcomes. By addressing gaps in traditional airway management and leveraging innovative design, the SuperNO2VA™ device has become a useful tool in modern anesthesiology.Item type: Item , Access status: Open Access , Canadian Spine Society: 25th Annual Scientific Conference, February 25 to 28, 2025, Fairmont Le Manoir Richelieu, La Malbaie, Charlevoix, Que., Canada.(Canadian journal of surgery. Journal canadien de chirurgie, 2025-11) Chan, Vivien; Gausper, Adeesya; Liu, Andy; Andras, Lindsay M; Illingworth, Kenneth D; Skaggs, David L; Imbeault, Rachelle; Dufresne, Justin; Parent, Stefan; Deschênes, Sylvain; Roy-Beaudry, Marjolaine; Legler, Jack; Benaroch, Lee; Pirshahid, Ali Ahmadi; Serhan, Olivia; Cheng, Draydon; Bartley, Debra; Carey, Timothy; Rasoulinejad, Parham; Singh, Supriya; Thornley, Patrick; Skaik, Khaled; Belanger, Genevieve; Phan, Philippe; Stratton, Alexandra; Matthew, Coyle; Kingwell, Stephen; Tsai, Eve; Wai, Eugene; Fonteyne, Hannah; Hryniuk, Sarah Southon; Parent, Eric; Huang, Eric; Stampe, Kyle; Beaulieu, Marie J; Chan, Monica; Thevasagayam, Gloria; Marino-Merlo, Gabriela; Malhotra, Armaan K; Lozano, Christopher S; Salaheen, Zaid; Malvea, Anahita; Shakil, Husain; Yefet, Leeor; Moghaddamjou, Ali; Molot-Toker, Sam; Witiw, Christopher D; Wilson, Jefferson R; Christian, Eisha; Quon, Jennifer L; Dirks, Peter B; Drake, James M; Rutka, James T; Kulkarni, Abhaya V; Zeller, Reinhard; Lebel, David E; Ibrahim, George M; Dionne, Antoine; Joncas, Julie; Barchi, Soraya; Parent, Stefan; Mac-Thiong, Jean-Marc; Yoon, Samuel; Aboelmagd, Karim; Sivakuganandan, Archana; Zulfiqar, Amna; Murphy, Anne; Moll, Stanley; Sorbara, Julia; Rocos, Brett; Lebel, David; Camp, Mark; Chan, Vivien; Shumilak, Geoffrey; Malhotra, Armaan K; Dansby, Jalen; Liu, Andy M; Chan-Tai-Kong, Andrew Michael; Lebel, David E; Illingworth, Kenneth D; Skaggs, David L; Lu, Daisy A; Wang, Zhi; Clar, Monique; Al-Shakfa, M Fidaa; Shen, Jesse; Rasoulinejad, Parham; Miyanji, Firoz; Kantar, Karim; Carey, Timothy; Bailey, Chris; Ghag, Ravi; Lanting, Brent; Singh, Supriya; Urquhart, Jennifer; Lung, Tiffany; Sardar, Zeeshan; Basu, Saumayajit; Gupta, Manish; Lewis, Stephen; Eissa, Abdullah T; Kato, So; Lenke, Lawrence; Jones, Kristen; Nielsen, Christopher; Basu, Saumyajit; Kelly, Michael; Smith, Justin; Strantzas, Samuel; Qiu, Yong; Pellise, Ferran; Alanay, Ahmet; Quraishi, Nasir; Gray, Randolph; Yoshida, Go; Aziz, Amer; Lewis, Stephen; Chaves, Jennyfer Paulla Galdino; Hsu, Brian; Sima, Stone; Singh, Bhisham; Kulkarni, Vinay; Diwan, Ashish; Ludwig, Taryn; Moghaddam, Farbod; Aminghafari, Mina; Choi, May; Nicholls, Fred; Seider, Eliana; Daunt, Lauren; Vashishth, Vanessa; Abbas, Aazad; Cadieux, Chloe; Lewis, Stephen; Ahmadi, Ali; Brzozowski, Pawel; Toobaie, Asra; Rasoulinejad, Parham; Fernandes, Renan Rodrigues; Young, James J; Urquhart, Jennifer; Bailey, Chris; McIntosh, Greg; Glennie, Andrew; Fisher, Charles; Perruccio, Anthony V; Rampersaud, Raja; Glennie, Andrew; Urquhart, Jennifer; Mishreky, Amir; Fisher, Charles; Rampersaud, Raja; Bailey, Chris; MacLean, Mark A; Julien, Lisa; Patriquin, Glenn; Leblanc, Jason; Greene, Ryan; Alant, Jacob; Barry, Sean; Glennie, R Andrew; Oxner, William; Christie, Sean D; Pedro, Karlo; Abbas, Aazad; Bailey, Christopher; Urquhart, Jennifer; MacIntosh, Greg; Glennie, Andrew; Fisher, Charles; Phan, Philippe; Rampersaud, Y Raja; Smith, Daniel P; Bigney, Erin E; Hebert, Jeffrey; Richardson, Eden A; Manson, Neil A; Abraham, Edward; Zein, Abdullah; Holt, Kyra; Isaac, Hannah; Kearney, Jill; Small, Chris; Evaniew, Nathan; Alduwaisan, Abdullah; Smith, Victoria; Whittaker, Tara; Eckenswiller, Denise; Soumbasis, Elias; Tanguay, Robert; Jacobs, W Bradley; Thomas, Kenneth C; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Nahanni, Celina; Lung, Tiffany S; Young, James J; Cadieux, Chloe N; Du, Jin Tong; Rampersaud, Raja; Glennie, Andrew; Dunning, Cynthia; Jones, Emma; Oxner, William; Lobo, Kaike; Łajczak, Paweł; Santos, Claudia; Rajab, Numa; Oliveira, Rafael; Silva, Yasmin Picanco; Barbosa, Ramon Guerra; Silva, Yan GMD; Abbas, Aazad; Sahi, Gurjovan; Du, Jin Tong; Johnson, Michael; Buchel, Edward; Toor, Jay; Kulkarni, Ronit; Bertolino, Melanie; Walton, Chase; Rivas, Gabriella; Glaser, John; Reitman, Charles A; Lawrence, James; Ravinsky, Robert; Pedro, Karlo; Fehlings, Michael; Alvi, Mohammed; Essa, Ahmad; Shakil, Husain; Malhotra, Armaan K; Nathens, Avery B; Badhiwala, Jetan; Yuan, Eva Y; He, Yingshi; Mathieu, Francois; Sklar, Michael C; Wilson, Jefferson; Witiw, Christopher D; Yoon, Samuel; Reda, Luke A; Malhotra, Armaan; Shakil, Hussain; Fehlings, Michael G; Witiw, Christopher D; Wilson, Jefferson R; Badhiwala, Jetan H; Sadiqi, Said; Muijs, Sander PJ; Dandurand, Charlotte; Dvorak, Marcel F; Oner, F Cumhur; AO Spine Knowledge Forum Trauma and Infection; Dionne, Antoine; Richard-Denis, Andréane; Phan, Philippe; Mputu, Pascal Mputu; Mac-Thiong, Jean-Marc; Le, Vivian Huong Hoang Thien; Mputu, Pascal Mputu; Richard-Denis, Andreane; Bernard, Francis; Cavayas, Yiorgos Alexandros; Dionne, Antoine; Mac-Thiong, Jean-Marc; Attabib, Najmedden A; Hong, Heather A; Kurban, Dilnur; Yang, Tianyu; Fallah, Nader; Cheng, Christiana L; Humphreys, Suzanne; Noonan, Vanessa K; El-Mughayyar, Dana; Craig, Michael; O'Connell, Colleen; Rick Hansen Spinal Cord Injury Registry Network; Shakil, Husain; Hu, Zixuan; Smith, Christopher W; Malhotra, Armaan K; Essa, Ahmad; Ling, Hui M; Khan, Zakariya M; Sejdic, Ervin; Colak, Errol; Witiw, Christopher D; Duguay, Maude; Hernandez, Juan David Cifuentes; Mac-Thiong, Jean-Marc; Dionne, Antoine; Bensoussan, Natan; Richard-Denis, Andreane; Carrier, Louis; Blanchard, Jocelyn; LaRue, Bernard; Paquette, Ariane; Silva, Yan Gabriel Morais; Nielsen, Christopher J; Bhatt, Vaidehi; Lewis, Stephen J; Rampersaud, Y Raja; Rosenstein, Brent; Montpetit, Chanelle; Vaillancourt, Nicolas; Dover, Geoffrey; Weiss, Christina; Papula, Lee Ann; Melek, Antonys; Fortin, Maryse; Fazlollahi, Ali M; Barak, Uri; Kalhor, Samira; Nguyen, Joshua Hien; Santaguida, Carlo; Raj, Ruheksh; Lewkonia, Peter; Rogan, Kyle; Marchuk, Allison; Barrett, Erin; Masson, Anand; Pratt, Brandy; Michaud, Danielle; Skyrda, Kateryna; Simms, Sierra; Yang, Michael; Herrington, Brandon J; Urquhart, Jennifer C; Rasoulinejad, Parham; Siddiqi, Fawaz; Gurr, Kevin; Bailey, Christopher S; Chayer, Mathieu; Phan, Philippe; Arnoux, Pierre-Jean; Wang, Zhi; Rawlinson, Jeremy; Aruwajoye, Olumide; Aubin, Carl-Éric; Samhat, Hussein; Pedro, Karlo M; Pirshahid, Ali Ahmadi; Charest-Morin, Raphaële; Gore, Genevieve; Filion, Kristian B; Lasry, Oliver; Levett, Jordan J; Dea, Nicolas; Evanview, Nathan; McIntosh, Greg; Weber, Michael H; Rinott, Nadav; Laflamme, Mathieu; McIntosh, Greg; Evaniew, Nathan; Weber, Michael H; Dea, Nicolas; Liu, Andy; Tuchman, Alexander; Mikhail, Christopher; Chan, Vivien; McDonald, James; Zaldivar, Julien; Dea, Nicolas; Koegl, Nikolaus; McIntosh, Greg; Evaniew, Nathan; Lonjon, Guillaume; Vassal, Matthieu; Dhenin, Alexandre; Perez, Alexis; Dupuy, Martin; Challier, Vincent; Castelain, Jean-Etienne; Ghailane, Soufiane; Campana, Matthieu; Lebhar, Jonathan; Guerin, Gilles; Pellet, Nicolas; Sabah, Yann; Chevillotte, Thomas; Darnis, Alice; Cristini, Joseph; Ferracci, François-Xavier; Delambre, Jérôme; Queinnec, Steffen; Delmotte, Alexandre; Marinho, Paulo; Gauthe, Rémi; Hannequin, Pierre; Gilard, Vianney; Meyblum, Jean; Perrin, Alexis; Pietton, Raphaël; Lonjon, Nicolas; Gennari, Antoine; Malhotra, Armaan K; Shakil, Husain; Essa, Ahmad; Evaniew, Nathan; Canadian Spine Outcomes and Research Network (CSORN) Investigators; Witiw, Christopher D; Wilson, Jefferson R; Dea, Nicolas; Al-Shawwa, Abdul; Craig, Michael; Ost, Kalum; Jacobs, W Bradley; Evaniew, Nathan; Lewkonia, Peter; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Thomas, Kenneth C; Yang, Michael MH; Adad, Julien-Cohen; Cadotte, David W; Wangai, Isaac; Nataraj, Andrew; Hojanepesov, Osman; Cadotte, David; Skarsgard, Matthew; Evaniew, Nathan; Paquet, Jerome; Dhaliwal, Perry; Attabib, Najmedden; Urquhart, Jennifer; Dea, Nicolas; Bailey, Chris; Karthikeyan, Vishwathsen; Shakil, Husain; Malhotra, Armaan; Lozano, Christopher; Wilson, Jefferson; Fehlings, Michael; Badhiwala, Jetan; Koegl, Nikolaus; McIntosh, Greg; Dea, Nicolas; Evaniew, Nathan; Charest-Morin, Raphaële; Kurtz, Daniel; Phan, Philippe; Sun, Christopher; Cho, Newton; Al-Shawwa, Abdul; Jacobs, Bradley; Evaniew, Nathan; Bouchard, Jacques; Casha, Steven; duPlessis, Stephan; Lewkonia, Peter; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Thomas, Kenneth; Yang, Michael; Cohen-Adad, Julien; Cadotte, David; Charest-Morin, Raphaële; Hansen, Landon; Yip, Stephen; Dea, Nicolas; Goodwin, Rory C; Fisher, Charles G; Bettegowda, Chetan; Versteeg, Anne L; Sahgal, Arjun; Laufer, Ilya; Rhines, Laurence; Sciubba, Daniel; Schuster, James; Weber, Michael; Lazary, Aron; Boriani, Stefano; Bettegowda, Chetan; Fehlings, Michael; Clarke, Michelle; Arnold, Paul; Gokaslan, Ziya; Fisher, Charles; Versteeg, Anne; Weber, Michael; De La Garza Ramos, Rafael; Shin, John; Pahuta, Mark; Luzatti, Alessandro; Disch, Alexander; Gasbarrini, Alessandro; Verlaan, Jorrit-Jan; Teixeira, William; Sahgal, Arjun; Laufer, Ilya; Lazary, Aron; Chou, Dean; Fisher, Charles; Gokaslan, Ziya; Fehlings, Michael; Rhines, Laurence; Mesfin, Addisu; Sciubba, Daniel; Bettegowda, Chetan; Goldschlager, Tony; Netzer, Cordula; Clarke, Michelle; O'Toole, John; Boriani, Stefano; Barzilai, Ori; Kawahara, Nori; Kumar, Naresh; Dea, Nicolas; Reynolds, Jeremy; Goodwin, Rory; Charest-Morin, Raphaële; AO Spine Knowledge Forum Tumor; Shakil, Husain; Malhotra, Armaan K; Essa, Ahmad; Karthikeyan, Vishwathsen; Lozano, Christopher S; Badhiwala, Jetan H; Sahgal, Arjun; Dea, Nicolas; Fehlings, Michael G; Kiss, Alex; Witiw, Christopher D; Redelmeier, Donald A; Wilson, Jefferson R; Kwan, William Chu; Koegl, Nikolaus; Dea, Nicolas; Fisher, Charles; Charest-Morin, Raphaële; Rocha, Alexandra; Renaud, Matthew; Urquhart, Jennifer; Singh, Supriya; Caceres, Marco Perez; Ahmed, Omer; Freire, Véronique; Shen, Jesse; Al-Shakfa, Fidaa; Boulé, Danielle; Wang, Zhi; Lozano, Christopher S; Malhotra, Armaan K; Karthikeyan, Vishwathsen; Shakil, Husain; Balasubramaniam, Neevya; Wilson, Jefferson R; Witiw, Christopher; Jacobs, W Bradley; Wang, Zhi; Dhaliwal, Perry; Santaguida, Carlo; Bailey, Chris; Bangsboll, Emily; Roach, Koren; Duncan, Neil; Salo, Paul; Bouchard, Jacques; Ronsky, Janet; Swamy, Ganesh; Ngana, Germain Sophie; Nassrullah, Zain; Alhantoobi, Mohamed; Al-Assiri, Suhail S; Al-Zailaie, Abdulaziz; Ngetich, Geofrey; Kwok, Desmond; Pahuta, Markian; Martinyuk, Amanda; Guha, Daipayan; Evaniew, Nathan; Malholtra, Armaan K; Charest-Morin, Raphaële; Soroceanu, Alex; Jacobs, W Bradley; Cadotte, David W; Dea, Nicolas; Halabian, Negeen; Deng, Jiawen; Alvi, Mohammed Ali; Pedro, Karlo M; Fehlings, Michael G; Cho, Newton; Al-Shawwa, Abdul; Jacobs, Bradley; Evaniew, Nathan; Lewkonia, Peter; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Thomas, Kenneth; Yang, Michael; Cadotte, David; Siddiqi, Omar; Urquhart, Jennifer; Fernandes, Renan Rodrigues; Wangai, Isaac; Walker, Taryn; Alanezi, Turki; Raj, Ruheksh; Bailey, Chris; Barbosa, Ramon Guerra; Pimenta, Newton; Silva, Yan; Tobin, Jacqueline; Martin, John; Kouame, Mark; Rivas, Gabriella; Reitman, Charles; Glaser, John; Lawrence, James; Ravinsky, Robert; Alfawaz, Thamer; Zhang, Tinghua; Dea, Nicolas; Evaniew, Nathan; Phan, Philippe; Outcomes, Canadian Spine; Network, Research; Karthikeyan, Vishwathsen; Shakil, Husain; Malhotra, Armaan; Lozano, Christopher; Wilson, Jefferson; Silva, Yan GMD; Barbosa, Ramon; de Souza Rodrigues Júnior, Erenaldo; Filho, Carlos Alberto Assunção; Gomes, Rodrigo; de Oliveira, Luis Fernando Weber; Fay, Mary; Christie, Sean; Barry, Sean; Lethbridge, Lynn; Oxner, William; Johnston, Emily; Glennie, Andrew; Belanger, Geneviève L; Wai, Eugene K; Skaik, Khaled; Smith-Forrester, Jenna; Rowicki, Michelle; Gillis, Justina; Jones, Karen; Freeman, Jason; Mitchell, Matt; MacLean, Emily; Hollahan, Renee; Hardy, Leslie; MacDonald, Christina; Decker, Alissa; Barry, Sean; Glennie, Andrew; Oxner, William; Weise, Lutz; Christie, Sean; Barter, Lauren; Glennie, Andrew; Christie, Sean; Zwicker, Cynthia Dunning; Oxner, Bill; Jaffe, Rachael; Malhotra, Armaan; Shakil, Husain; Witiw, Christopher; Bradley, Sarah; Martin, John; Rivas, Gabriella; Seeger, Sydney; Glaser, John; Reitman, Charles; Lawrence, James; Ravinsky, Robert; Daunt, Lauren I; Vashishth, Vanessa; Seider, Eliana; Abbas, Aazad; Daziano, Mauricio Campos; Rienmüller, Anna C; Ames, Christopher; Lewis, Stephen J; Kow, Chien Yew; Moghaddam, Farbod; Choi, May; Nicholls, Fred; Cadieux, Chloe; Rienmüller, Anna C; Kwan, Kenny Yat Hong; Qiu, Yong; Pellise, Ferran; Alanay, Ahmet; Smith, Justin; Quraishi, Nasir; Gray, Randolph; Basu, Saumyajii; Yoshida, Go; Lenke, Lawrence; Lewis, Stephen J; Nielsen, Christopher J; Alavi, Fatemeh; Dantas, Francois; Rampersaud, Y Raja; Lewis, Stephen J; Łajczak, Paweł; Silva, Yasmin Picanco; Ayesha, Ayesha; Von Quednow, Enzo; Jabbar, Rabbia; Zottele, Mariana Zamprogno; Nascimento, Gabriela Fonseca; Rocha, Fabio Victor Vieira; Sahin, Oguz Kagan; Sharma, Eshita; Barbosa, Ramon; Fagundes, Walter; Silva, Yan GMD; Kow, Chien Yew; Moghaddam, Farbod; Choi, May; Nicholls, Fred; Chaves, Jennyfer Paulla Galdino; Hsu, Brian; Sima, Stone; Singh, Bhisham; Diwan, Ashish; Smith, Victoria; Evaniew, Nathan; Soroceanu, Alex; Lewis, Steve; Nicholls, Fred; Swamy, Ganesh; Abdelnour, Mark; Cierson, Tanya; Mumtaz, Rohail; Zhang, TingHua; Alhowsawi, Mamdoh; Swamy, Ganesh; Thomas, Kenneth; Soroceanu, Alex; Wang, Zhi; Stratton, Alexandra; Kingwell, Stephen; Wai, Eugene; Tsai, Eve; Phan, Philippe Tran Nhut; Cadieux, Chloe; Kato, So; Klineberg, Eric; Yilgor, Caglar; Kelly, Michael; Lenke, Lawrence; Shaffrey, Christopher; Cheung, Kenneth; Berven, Sigurd; Matsuyama, Yukihiro; Pellise, Ferran; Dahl, Benny N; Spruit, Maarten; Alanay, Ahmet; Lewis, Stephen J; Eissa, Abdullah T; Kato, So; Lenke, Lawrence; Jones, Kristen; Nielsen, Christopher; Basu, Saumyajit; Kelly, Michael; Strantzas, Samuel; Qiu, Yong; Pellise, Ferran; Alanay, Ahmet; Quraishi, Nasir; Gray, Randolph; Yoshida, Go; Aziz, Amer; Lewis, Stephen; Chan, Vivien; Etigunta, Suhas; Malhotra, Armaan K; Shumilak, Geoffrey; Lebel, David E; Illingworth, Kenneth D; Skaggs, David L; Zohar, Ariel; Loomans, Janneke; Pellise, Ferran; Kato, So; Sardar, Zeeshan; Lenke, Lawrence G; Lewis, Stephen J; Switzer, Lily; Aboelmagd, Karim; Anthony, Alison; Nadler, Emma; Dermott, Jennifer A; Camp, Mark; Lebel, David E; Aboelmagd, Karim; Versteeg, Anne; Camp, Mark; Zeller, Reinhard; Lebel, David; Batista, Nuno M; Liu, Taylor; Romeo, Jessica; Tice, Andrew; Jarvis, James; Smit, Kevin; Imbeault, Rachelle; Shen, Jesse; Parent, Stefan; Alzakri, Abdulmajeed; Turcot, Olivier; Beauséjour, Marie; Roy-Beaudry, Marjolaine; Barchi, Soraya; Turgeon, Isabelle; Yoon, Samuel; Rutz, Erich; Percival, Mia; Johnson, Michael B; Lundine, Kris; Chan, Vivien; Shumilak, Geoffrey; Malhotra, Armaan K; Lebel, David E; Illingworth, Kenneth D; Skaggs, David L; Nielsen, Christopher J; Alavi, Fatemeh; Dantas, Francois; Rampersaud, Y Raja; Lewis, Stephen J; Chan, Vivien; Kong, Andrew Michael Chan Tai; Gausper, Adeesya; Etigunta, Suhas; Liu, Andy M; Illingworth, Kenneth D; Skaggs, David L; Łajczak, Paweł; Sharma, Eshita; Petry, Iago Nathan Simon; Jabbar, Rabbia; Silva, Yasmin Picanço; Rocha, Fabio Victor Vieira; Sahin, Oguz Kagan; da Silva Lobo, Kaike Eduardo; Ayesha, Ayesha; Ahmed, Aisha Rizwan; Fagundes, Walter; Silva, Yan GMD; Abbas, Aazad; Pedro, Karlo; Bailey, Christopher; Phan, Philippe; Uruqhurt, Jennifer; McIntosh, Greg; Rampersaud, Y Raja; Cadieux, Chloe; Lung, Tiffany; Du, Jin Tong; Nahanni, Celina; Nielsen, Christopher; Lewis, Stephen J; Rampersaud, Raja Y; Ross, Nicolas; Aleman, Carlos; Dhenin, Alexandre; Vassal, Matthieu; Lonjon, Guillaume; Salimi, Hamidullah; Terai, Hidetomi; Tamai, Koji; Uematsu, Masato; Katsuda, Hiroshi; Sharma, Eshita; Ayesha, Ayesha; Lobo, Kaike Eduardo Silva; Pomianoski, Beatriz Westphalen; Kotochinsky, Jose Martin; Silva, Yan GMD; Barbosa, Ramon Guerra; Pimenta, Newton; Silva, Yan; Kim, Jieun; Roberts, Richard; Kortbeek, Frank; MacLean, Mark A; Rampersaud, Y Raja; Bailey, Chris; Fisher, Charles; Glennie, R Andrew; Lonjon, Guillaume; Dhenin, Alexandre; Vassal, Matthieu; Van Brenk, Hannah; Bigney, Erin E; Manson, Neil A; Small, Chris; Abraham, Edward; Attabib, Najmedden; Kearney, Jill; Richardson, Eden A; deVries, Gwyneth; Dombrowski, Stephan; CSORN Principal Investigators; Hebert, Jeffrey; Barbosa, Ramon Guerra; Pimenta, Newton; Silva, Yan; Fernandes, Renan Rodrigues; Jacobs, Bradley; Witiw, Christopher; Wang, Zhi; Dhaliwal, Perry; Santaguida, Carlo; Bailey, Christopher; Faridi, Sufyan; Bigney, Erin; Hebert, Jeffrey; Manson, Neil; Abraham, Edward; Small, Chris; Richardson, Eden; Kearney, Jill; Attabib, Najmedden; Rampersaud, Y Raja; Power, J Denise; Kapoor, Mohit; Perruccio, Anthony V; Sharma, Eshita; Lobo, Kaike Eduardo Silva; Ayesha, Ayesha; Łajczak, Paweł; Pomianoski, Beatriz Westphalen; Silva, Yan GMD; Wang, Zhi; Jacobs, Bradley; Witiw, Christopher; Dhaliwal, Perry; Santaguida, Carlo; Bailey, Chris; Wright, Alicia; Rosenstein, Brent; Montpetit, Chanelle; Vaillancourt, Nicolas; Fortin, Maryse; Rosenstein, Brent; Bergevin, Maxime; Bobeuf, Florian; Bherer, Louis; Pageaux, Benjamin; Roy, Mathieu; Fortin, Maryse; Wolfe, Daniel; Dover, Geoffrey; Boily, Mathieu; Fortin, Maryse; Nadler, Emma; Lebel, David E; Kim, Dorothy J; Dermott, Jennifer A; Wagman, Emma; Kim, Dorothy J; Nadler, Emma; Lebel, David E; Dermott, Jennifer A; Provost, Myriam; Cobetto, Nikita; Beausejour, Marie; Joncas, Julie; Rojas, Francisca; Tran, Shi-Jia; Sharma, Dhawal; Balondona, Aurelien; Labelle, Hubert; Aubin, Carl-Eric; Chan, Vivien; Michael, George; Illingworth, Kenneth D; Skaggs, David L; Thibault, Jérémie; Dionne, Antoine; Mac-Thiong, Jean-Marc; Olijnyk, Leonardo; Le, Vivian Huong Hoang Thien; Al-Shakfa, Fidaa; Florial, Edisond; Shedid, Daniel; Yuh, Sung-Joo; Boubez, Ghassan; Shen, Jesse; Wang, Zhi; Le, Vivian Huong Hoang Thien; Olijnyk, Leonardo; Al-Shakfa, Fidaa; Florial, Edisond; Shedid, Daniel; Yuh, Sunj-Joo; Boubez, Ghassan; Wang, Zhi; Truong, Van Tri; Dang, The Khanh; Osman, Galil; Al-Shakfa, Fidaa; Boulé, Danielle; Phan, Philippe; Shen, Jesse; Wang, Zhi; Versteeg, Anne; Abdoelmagd, Karim; Camp, Mark; Lebel, David; Hopyan, Sevan; Lewis, Stephen; Essa, Ahmad; Shakil, Husain; Malhotra, Armaan K; Nathens, Avery B; Yuan, Eva Y; He, Yingshi; Jack, Andrew S; Mathieu, Francois; Anekstien, Yoram; Azad, Tej D; Wilson, Jefferson R; Witiw, Christopher D; Bond, Michael; Beresford, Aidan; Noonan, Vanessa K; Rotem-Kohavi, Naama; Dvorak, Marcel F; Kwon, Brian K; Liu, Guiping; Sutherland, Jason M; Ryan, Gareth; Smith, Victoria; Nicholls, Fred; Lischynski, Jennifer R; Brar, Karnvir; Siddiqui, Aasiyah; Galdino, Jennyfer; Ajoku, Uchenna; Vega, Miguel; Alizadeh, Arsilan; Siddiqui, Faisal; Zeiler, Frederick; Dhaliwal, Perry; Whitten, Tara A; Rotem-Kohavi, Naama; Thorogood, Nancy; Humphreys, Suzanne P; Noonan, Vanessa K; Ho, Chester; Bakal, Jeffrey A; Pedro, Karlo; Fehlings, Michael; Alvi, Mohammed; Pedro, Karlo; Fehlings, Michael; Alvi, Mohammed; Essa, Ahmad; Malhotra, Armaan K; Shakil, Husain; Nathens, Avery B; Yuan, Eva Y; He, Yingshi; Jack, Andrew S; Mathieu, Francois; Wilson, Jefferson R; Witiw, Christopher D; Fehlings, Michael; Pedro, Karlo; Alvi, Mohammed; Dionne, Antoine; Richard-Denis, Andréane; Brouillard, Émile; Lassassy, Ismail; Bourassa-Moreau, Etienne; Khoueir, Paul; Wang, Zhi; Mac-Thiong, Jean-Marc; Bond, Michael; Beresford, Aidan; Noonan, Vanessa K; Rotem-Kohavi, Naama; Dvorak, Marcel F; Kwon, Brian K; Liu, Guiping; Sutherland, Jason M; Essa, Ahmad; Malhotra, Armaan K; Shakil, Husain; Nathens, Avery B; Yuan, Eva Y; He, Yingshi; Mathieu, Francois; Sklar, Michael C; Wilson, Jefferson R; Witiw, Christopher D; Badhiwala, Jetan; Sharma, Ojasvi; Levett, Jordan J; Weber, Michael H; Barbosa, Ramon Guerra; Lages, Gustavo; Alencar, Johmeson; Sadiqi, Said; Hakbijl-van der Wind, Aline J; Egberts, Sylvia; Stolwijk, Janneke; Osterthun, Rutger; van Diemen, Tijn; Oner, F Cumhur; Post, Marcel WM; AO Spine Knowledge Forum Trauma and Infection; Hong, Heather A; Parsons, Jessica; Xu, Jijie; Walden, Kristen; Fallah, Nader; Cheng, Christiana L; Attabib, Najmedden; Christie, Sean D; Craven, Cathy B; Fehlings, Michael; Fourney, Daryl R; Kainth, Hardeep S; Kwon, Brian K; Linassi, Gary A; Moganathas, Saranjan; Paquet, Jerome; Mac-Thiong, Jean-Marc; Townson, Andrea F; Urquhart, Jennifer; Tsai, Eve; Whelan, Alex J; Noonan, Vanessa K; ISNCSCI Working Group; Ye, Vincent C; Malhotra, Armaan K; Shakil, Husain; Essa, Ahmad; Witiw, Christopher D; Bond, Michael; Beresford, Aidan; Noonan, Vanessa K; Rotem-Kohavi, Naama; Dvorak, Marcel F; Kwon, Brian K; Liu, Guiping; Sutherland, Jason M; Karthikeyan, Vishwathsen; Lozano, Christopher; Malhotra, Armaan; Shakil, Husain; Wilson, Jefferson; Witiw, Christopher; Badhiwala, Jetan; Chenevert, Alexandre; Lanoue, Charlotte; Couture, Jérôme; Bédard, Sonia; Gammel, Juliette; Silvestre, Jason; Rivas, Gabrielle; Lawrence, James; Ravinsky, Robert; Dermott, Jennifer A; Jaakkimainen, Liisa; To, Teresa; Bouchard, Maryse; Howard, Andrew W; Lebel, David E; Ostertag, Curtis A; Whittaker, Tara; Nicholls, Fred H; Dukkipati, Siril Teja; Driscoll, Mark; Lu, Daisy A; Sahraoui, Oussama; Danino, Alain; Wang, Zhi; Sahi, Gurjovan; Du, Jin Tong; Abbas, Aazad; Hanna, Sager; Berrington, Neil; Almojuela, Alysa; Johnson, Michael; Lewis, Stephen; Goytan, Michael; Toor, Jay; Du, Jin Tong; Lung, Tiffany; Nahanni, Celina; Cadieux, Chloe; Dandal, Gavin; Anderson, Nicola; Lewis, Stephen; Nielsen, Christopher; Massicote, Eric; Rampersaud, Raja; Skaik, Khaled; Phan, Philippe; Belanger, Genevieve; Kingwell, Stephen; Stratton, Alexandra; Coyle, Matthew; Wai, Eugene; Olijnyk, Leonardo; Kaiser, Paul; Brunette-Clément, Tristan; Shedid, Daniel; Yuh, Sung-Joo; Barbosa, Ramon Guerra; Lages, Gustavo; Pimenta, Newton; Murray, Sean A; Driscoll, Mark; Lung, Tiffany; Cadieux, Chloe; Du, Jin Tong; Lazarus, Jed; Nahanni, Celina; Nielsen, Christopher; Rampersaud, Raja; Yoo, Arim; Gandhi, Pranjan; Rajapaksege, Nathasha; Hart, Shannon L; Shi, Victoria; Pahuta, Markian; Guha, Daipayan; Lu, Daisy A; Wang, Zhi; Al-Shakfa, M Fidaa; Shen, Jesse; Mulhall, Drew; Kow, Chien Yew; Masson, Anand Oliveira; Veilleux, Catherine; du Plessis, Stephan; Casha, Steve; Thomas, Ken; Yang, Michael; Valošek, Jan; Bouthillier, Maxime; Cohen-Adad, Julien; Spinal Cord Toolbox team; Li, Ling Jing; Dukkipati, Siril Teja; Driscoll, Mark; Ludwig, Taryn; Mina, Mina; Gibbon, Stephanie; Bello, Oluwakanyinsola; Anderson, Sarah J; Willetts, Lian; Lewkonia, Peter; Deprato, Andy; Chalmers, Kieran; Tice, Andrew; Romeo, Jessica; Carsen, Sasha; Smit, Kevin; Hadi, Ayesha; Kim, Dorothy J; Doria, Andrea S; Khalvati, Farzad; Chen, Chaojun; Dermott, Jennifer A; Lebel, David E; Dufresne, Justin; Aubert, Benjamin; Imbeault, Rachelle; Roy-Beaudry, Marjolaine; Cresson, Thierry; Parent, Stefan; Liu, Taylor; Tice, Andrew; Romeo, Jessica; Smit, KevinItem type: Item , Access status: Open Access , Can Social Function Improve in Older Patients Undergoing Multi-Level Spinal Deformity Surgery?(Global spine journal, 2025-12) Campos Daziano, Mauricio; Daunt, Lauren; Vashishth, Vanessa; Seider, Eliana; Abbas, Aazad; Rienmueller, Anna; Matsuyama, Yukihiro; Qiu, Yong; Kelly, Michael; Smith, Justin S; Dahl, Benny T; Spruit, Maarten; de Kleuver, Marinus; Polly, David W; Sembrano, Jonathan; Pellisé-Urquiza, Ferran; Cheung, Kenneth MC; Alanay, Ahmet; Lenke, Lawrence G; Shaffrey, Christopher I; Berven, Sigurd H; Lewis, Stephen J; PEEDS Study Group and AO Spine Knowledge Forum DeformityDesignPost-hoc analysis of data from prospective multicenter observational study.ObjectivesAdult spinal deformity (ASD) can have significant impact on various aspects of a patient's social life. This study aims to examine the impact of ASD surgery on the social functioning among elderly patients.MethodsPatients ≥60 years undergoing ≥5 levels of spinal fusion from 12 international centers were enrolled and followed up 2 years post-operatively. The outcome measures of interest in the current report were questions 14 and 18 of the Scoliosis Research Society-22r questionnaire (SRS-22r), and question 9 from the Oswestry Disability Index (ODI).Results219 patients met the inclusion criteria, with a median age of 67.5 and 80.4% being female. More than a third were employed or homemakers, 60.3% were retired and 25.7% showed cognitive impairment. For the SRS-22r Q14, at baseline, 40.6% of patients felt their back condition moderately or severely affected their personal relationships compared to 14.7% at 2-years. For SRS-22r Q18, at baseline, 47.7% of patients felt their back often or very often limited them going out with friends/family compared to 17.1% at 2-years. For the ODI, Q9, 8.7% of patients felt that their social was normal and does not cause them extra pain pre-op compared to 44.1% of patients at 2-years.ConclusionWhile many factors can affect a patient's social function, in this cohort ASD surgery had a positive impact on social function.The ClinicalTrails.gov identifier: NCT02035280.Item type: Item , Access status: Open Access , Is more better? Multicenter analysis of the incidence and mechanisms of multiple pelvic fixation failure in adult spinal deformity surgery.(The spine journal : official journal of the North American Spine Society, 2025-12) Jankowski, Pawel P; Tahmasebpour, Paritash; Matthews, Spencer; Passias, Peter G; Martin, Christopher; Sembrano, Jonathan; Kleck, Christopher; Ou-Yang, David; Strobeck, Jack; Javidan, Yashar; Hideshima, Kelsey; Shahzad, Hania; Odland, Kari; Shaffrey, Christopher; Anyiwe, Bishop; Polly, David; Spinal Pelvic Study GroupBackground context
High mechanical stress at the lumbosacral junction (LSJ) contributes to elevated failure rates in long-segment adult spinal deformity (ASD) fusions. To enhance fusion across the LSJ and preserve correction after ASD surgery, pelvic fixation has become a critical component of surgical constructs. However, conventional techniques that use a single point of fixation per side remain prone to implant failure. Biomechanical studies indicate that multiple-point pelvic fixation (MPF) may improve load distribution and construct stability, yet supporting clinical evidence remains limited.Purpose
The purpose of this study was to assess the incidence, mechanisms, and potential protective strategies for pelvic fixation failure (PFF) utilizing multiple pelvic fixation (MPF) constructs in adult spinal deformity (ASD) surgery.Study design/setting
Multicenter retrospective-prospective cohort study conducted across four tertiary spine centers from 2010 to 2024.Patient sample
229 ASD patients (age ≥ 18 years, minimum of five instrumented levels) with pelvic fixation (S2-alar-iliac [S2AI] and/or iliac screws) with a minimum 1-year follow-up, consecutively collected (2010-2024). MPF was defined as having more than two pelvic fixation points per patient, with at least one sacral-alar-iliac (SAI) screw per side.Outcome measures
The primary endpoint was establishing the incidence of pelvic fixation failure requiring reoperation in MPF constructs. The secondary endpoint was to determine the mechanisms underlying PFF in MPF constructs.Methods
PFF endpoints included implant failure requiring reoperation (RR), all-modality failure RR, all-modality failure not requiring reoperation (NRR), screw loosening (NRR), and rod breakage. Patient information including demographic data and health history (age, sex, BMI), instrumented levels (IL), three-column osteotomy (3CO), interbody fusion (IBF), screw (iliac, S2AI, length, diameter), rod (diameter, material), rod pattern (number crossing lumbopelvic junction), pre- and post-surgery (pelvic incidence, pelvic tilt, T1 pelvic angle (TPA), PI-LL, and sacral slope parameters were collected. Failure rates were compared with single-fixation benchmarks from Eastlack et al. (2022) using one-sample z-tests for proportions. Radiographic parameters and implant characteristics were analyzed between the failure and non-failure groups.Results
From the 229 patients analyzed (52.4% female, mean age 67.2, mean IL 11.3, 3CO 27.9%, L5-S1 IBF 45.8%, L4-L5 IBF 34.1%) 3.1% (n = 7) experienced PFF requiring reoperation after 1 year. Mean screws per patient were 3.6 (S2AI (77.7%). MPF implants had a mean length of 88.7mm and a mean diameter of 9.53mm. Mean rods across the LS junction were 3.37 with 50.7% cobalt chrome. PFF due to mechanical failure requiring reoperation after 1 year was 2.2% (n = 5). The MPF rate without reoperation was 6.6% (n = 15). Further mechanisms of failure included rod breakage (2.2%; n = 5) [2 (0.9%) requiring reoperation] and screw loosening (5.2%; n = 12). Failures tended to be associated with greater preoperative deformity, evidenced by preoperative pelvic tilt (29.6° vs. 26.2°) and TPA (30.4° vs. 27.4°), as well as shorter screw length (86.7 vs. 88.8mm).Conclusions
Multiple-point pelvic fixation reduces the risk of PFF in long-segment ASD surgery. Compared with multicenter reports using single- or limited-point fixation strategies, the observed failure rate, including both revision and non-revision cases, was lower in constructs with multiple pelvic anchors. Load distribution across multiple fixation points enhances construct durability and provides a more stable foundation for long-segment fusion, mitigating implant failure and the need for revision surgery.Item type: Item , Access status: Open Access , Using the Quality Outcomes Database to Identify Minimum Clinically Important Differences for Patients With Cervical Spondylotic Myelopathy.(Neurosurgery, 2026-01) Asher, Anthony L; Lakomkin, Nikita; Mummaneni, Praveen V; Michalopoulos, Giorgos D; Johnson, Sarah E; Park, Paul; Gottfried, Oren N; Asher, Anthony M; Katsos, Konstantinos; Potts, Eric A; Foley, Kevin T; Wang, Michael Y; Knightly, John J; Shaffrey, Christopher I; Virk, Michael S; Fu, Kai-Ming G; Tumialan, Luis M; Turner, Jay D; Uribe, Juan S; Upadhyaya, Cheerag; Shaffrey, Mark E; Coric, Domagoj; Chou, Dean; Haid, Regis W; Bisson, Erica F; Bydon, MohamadBackground and objectives
Minimum clinically important differences (MCIDs) for patient-reported outcome metrics (PROMs) in patients with cervical spondylotic myelopathy (CSM) lack consensus on the most appropriate calculation method. This retrospective study aimed to identify the optimal MCIDs for commonly used PROMs in CSM.Methods
The CSM database from the Quality Outcomes Database SpineCORe Study Group was analyzed. Baseline, 3-month, and 24-month PROM values for Neck Disability Index (NDI), 5-dimension Euro-quality of life (EQ-5D) in quality-adjusted life years, modified Japanese Orthopaedic Association (mJOA) score, and neck/arm pain numeric rating scale (NRS) were collected. MCIDs were calculated for each PROM using previously validated techniques. MCID values were compared using the area under the curve (AUC) with the North American Spine Society satisfaction scale as an anchor.Results
A total of 1141 patients with CSM undergoing surgery were included in this analysis. Improvement of ≥30% from baseline was the optimal MCID for NDI and neck/arm NRS. At 24 months, the optimal percentage cutoff MCID for these instruments resulted in AUCs of 0.76, 0.72, and 0.67, similar to the 30% improvement method, with AUCs of 0.73, 0.71, and 0.67, respectively. Numeric cutoffs (0.065 at 3 months; 0.149 at 24 months) were the superior MCIDs for EQ-5D. For mJOA score, a severity-adjusted MCID outperformed other methods, yielding an AUC of 0.67 at 24 months. MCIDs were achieved in 63% of patients for NDI, 59% for neck pain NRS, 61% for arm pain NRS, 52% for EQ-5D, and 59% for mJOA score at 24 months.Conclusion
Using the Quality Outcomes Database SpineCORe data set, we defined optimal MCIDs for key PROMs in CSM. A ≥30% improvement from baseline was optimal in NDI and arm/neck NRS. An absolute numeric cutoff was superior for EQ-5D (0.149 at the 24-month follow-up). A severity-adjusted MCID performed best for mJOA score. These redefined benchmarks better capture the treatment impact and guide care decisions for patients with CSM.Item type: Item , Access status: Open Access , Anatomic parameters for diagnosing congenital cervical stenosis via computed tomography.(Surgical and radiologic anatomy : SRA, 2026-01) Shin, David; Shin, Brandon; Im, Daniel; Tang, Timothy; Dinh, Chandler; Cummings, Carson; Brandt, Zachary; Nguyen, Kai; Carter, Davis; Carter, Mei; Razzouk, Jacob; Taka, Taha M; Harianja, Gideon; Yacoubian, Vahe; Abd-El-Barr, Muhammad; Wycliffe, Nathaniel; Cheng, Wayne; Danisa, OlumidePURPOSE: To establish parameters for congenital cervical stenosis (CCS) using computed tomography (CT), assessing influences of patient sex, race, and ethnicity. METHODS: Measurements were collected of anteroposterior diameter (APD), interpedicular distance (IPD) and cervical intervertebral foramen dimensions (CIFD) from 1000 patients between 18 and 35 years of age without spinal pathology. CCS was determined as two standard deviations below the mean of the collected measurements. RESULTS: Irrespective of vertebral level, mean anatomic APD, CIFD and IPD measurements were as follows: 14.94 ± 1.99 mm for APD, 6.58 ± 1.45 mm and 6.68 ± 1.45 mm for left and right widths, of 9.30 ± 2.30 mm and 9.25 ± 2.80 mm for left and right heights, 57.0 ± 19.2 mm2 and 59.5 ± 20.3 mm2 for left and right areas, and 25.4 ± 1.78 mm for IPD. Irrespective of vertebral level, threshold values for CCS were 10.96 mm for APD, 3.68 mm and 3.78 mm for left and right widths, of 4.70 mm and 3.65 mm for left and right heights, 20.6 mm2 and 19 mm2 for left and right areas, and 21.8 mm for IPD. Males demonstrated larger CCS threshold values than females for left and right CIFD area and APD. African American patients had smaller CIFDs and APD, and subsequent CCS thresholds compared to White patients. CONCLUSIONS: This study reports measurements of CIFD, IPD, and APD to establish quantitative thresholds for diagnosis of CCS. CCS thresholds were significantly influenced by patient sex, race, and ethnicity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00276-025-03797-4.Item type: Item , Access status: Open Access , Exact Lagrangian fillings of twist-spun torus linksHughes, James; Chen, Vincent; Galloway, Patton; Wei, LucianaWe construct exact Lagrangian fillings of Legendrian torus links Λ(k,n−k) that are fixed by a Legendrian loop that acts by 2πℓ/n rotation. Using these rotationally symmetric fillings, we produce fillings of the corresponding Legendrian twist-spun tori. Our construction is combinatorial in nature, relating symmetric weakly separated collections and plabic graphs to symmetric Legendrian weaves via the T-shift procedure of Casals, Le, Sherman-Bennett, and Weng. The main technical ingredient in this process is a necessary and sufficient condition for the existence of maximal weakly separated collections of k-element subsets of {1,…,n} that are fixed by addition of ℓ modulo n.Item type: Item , Access status: Open Access , Exact Lagrangian fillability of 3-braid closures(Bulletin of the London Mathematical Society) Hughes, James; Ma, JiajieItem type: Item , Access status: Open Access , Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.(Allergy, 2020-11) Riedl, Marc A; Maurer, Marcus; Bernstein, Jonathan A; Banerji, Aleena; Longhurst, Hilary J; Li, H Henry; Lu, Peng; Hao, James; Juethner, Salomé; Lumry, William R; HELP InvestigatorsBackground
Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks in the phase 3 HELP Study.Objective
To assess time to onset of effect and long-term efficacy of lanadelumab, based on exploratory findings from the HELP Study.Methods
Eligible patients with HAE type I/II received lanadelumab 150 mg every 4 weeks (q4wks), 300 mg q4wks, 300 mg q2wks, or placebo. Ad hoc analyses evaluated day 0-69 findings using a Poisson regression model accounting for overdispersion. Least-squares mean monthly HAE attack rate for lanadelumab was compared with placebo. Intrapatient comparisons for days 0-69 versus steady state (days 70-182) used a paired t test for continuous endpoints or Kappa statistics for categorical endpoints.Results
One hundred twenty-five patients were randomized and treated. During days 0-69, mean monthly attack rate was significantly lower with lanadelumab (0.41-0.76) vs placebo (2.04), including attacks requiring acute treatment (0.33-0.61 vs 1.66) and moderate/severe attacks (0.31-0.48 vs 1.33, all P ≤ .001). More patients receiving lanadelumab vs placebo were attack free (37.9%-48.1% vs 7.3%) and responders (85.7%-100% vs 26.8%). During steady state, the efficacy of lanadelumab vs placebo was similar or improved vs days 0-69. Intrapatient differences were significant with lanadelumab 300 mg q4wks for select outcomes. Lanadelumab efficacy was durable-HAE attack rate was consistently lower vs placebo, from the first 2 weeks of treatment through study end. Treatment emergent adverse events were comparable during days 0-69 and 70-182.Conclusion
Protection with lanadelumab started from the first dose and continued throughout the entire study period.Item type: Item , Access status: Open Access , Community Health Worker Optimization of Antihypertensive Care in HIV (COACH): Study protocol for a pilot trial of an intervention to improve hypertension care among Tanzanians with HIV.(PloS one, 2024-01) Min Htike, Wai Yan; Manavalan, Preeti; Wanda, Lisa; Haukila, Kelvin; Mmbaga, Blandina T; Sakita, Francis M; Zebedayo, Rennyda; Gwasma, Francis; Jafar, Tazeen; Bosworth, Hayden B; Thielman, Nathan M; Hertz, Julian TObjective
This study will evaluate the feasibility and preliminary effectiveness of the COACH (Community Health Worker Optimization of Antihypertensive Care in HIV) intervention, which integrates hypertension management into existing HIV care for people living with HIV (PLWH) in Tanzania.Methods
The study will be conducted at two HIV Care and Treatment Centers (CTCs) in Tanzania. In a single-arm pre-post feasibility trial, 100 PLWH with hypertension will be enrolled and will receive the six-month intervention. The COACH intervention includes six monthly hypertension educational sessions delivered by community health workers (CHWs) and integrated within HIV CTC visits, monthly blood pressure monitoring, follow up care coordination, fully subsidized antihypertensive medications, a standardized antihypertensive treatment algorithm, and training for providers. The intervention's implementation outcomes will be evaluated using the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework, and the primary study outcome (reach of the intervention) will be the proportion of all scheduled intervention sessions attended by participants, a measure of feasibility. Secondary clinical effectiveness outcomes will include adherence to antihypertensive medication, blood pressure control, body mass index, cardiovascular risk, and hypertension knowledge.Significance
The COACH intervention has the potential to significantly improve hypertension management among PLWH in Tanzania by leveraging the existing HIV care infrastructure and CHWs. This study will provide crucial insights into the feasibility and potential effectiveness of the intervention in integrating hypertension care into HIV services, informing larger-scale implementation and policy changes in Tanzania and other resource-limitted settings.Trial registration
Clinical trials.gov Identifer: NCT06503991.Item type: Item , Access status: Open Access , Association of Race and Ethnicity with Genomic Testing at a Comprehensive Cancer Center in North Carolina.(Cancer research communications, 2024-11) Meernik, Clare; Wang, Frances; Raveendran, Yadurshini; Green, Michelle F; Check, Devon K; Bosworth, Hayden B; Sutton, Linda M; Strickler, John H; Akinyemiju, Tomi FSignificance
Non-Hispanic Black patients diagnosed with prostate cancer between 2014 and 2019 and treated at a comprehensive cancer center were less likely to use tumor-specific genomic testing compared with non-Hispanic White patients. Disparities in the use of precision oncology technologies should be monitored and addressed to ensure equitable cancer care.Item type: Item , Access status: Open Access , Cognitive Mediators of Change in Physical Functioning in Response to a Multifaceted Intervention for Managing Osteoarthritis.(International journal of behavioral medicine, 2018-04) Taylor, Shannon Stark; Oddone, Eugene Z; Coffman, Cynthia J; Jeffreys, Amy S; Bosworth, Hayden B; Allen, Kelli DPurpose
Although non-pharmacological interventions have been shown to improve physical functioning in individuals with osteoarthritis (OA), the mechanisms by which this occurs are often unclear. This study assessed whether changes in arthritis self-efficacy, perceived pain control, and pain catastrophizing mediated changes in physical functioning following an osteoarthritis intervention involving weight management, physical activity, and cognitive-behavioral pain management.Method
Three hundred Veteran patients of 30 primary care providers with knee and/or hip OA were cluster randomized to an OA intervention group or usual care. The OA intervention included a 12-month phone-based patient behavioral protocol (weight management, physical activity, and cognitive-behavioral pain management) plus patient-specific OA treatment recommendations delivered to primary care providers.Results
Using linear mixed models adjusted for provider clustering, we observed that baseline to 6-month changes in arthritis self-efficacy and pain control partially mediated baseline to 12-month physical functioning improvements for the intervention group; catastrophizing did not.Conclusion
Findings of a mediating role of arthritis self-efficacy and pain control in intervention-related functional changes are consistent with hypotheses and align with theoretical assertions of the role of cognitions in cognitive and behavioral interventions for chronic pain. However, contrary to hypotheses, catastrophizing was not found to be a mediator of these changes.Item type: Item , Access status: Open Access , Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer.(Journal of geriatric oncology, 2019-03) Sitlinger, Andrea; Shelby, Rebecca A; Van Denburg, Alyssa N; White, Heidi; Edmond, Sarah N; Marcom, Paul K; Bosworth, Hayden B; Keefe, Francis J; Kimmick, Gretchen GObjective
To explore the impact of symptoms on physical function in women on adjuvant endocrine therapy for breast cancer.Methods
Eligible women were postmenopausal, had hormone receptor positive, stage I-IIIA breast cancer, completed surgery, chemotherapy, radiation, and on adjuvant endocrine therapy. At a routine follow-up visit, women (N = 107) completed standardized symptom measures: Brief Fatigue Inventory, Brief Pain Inventory, Menopause Specific Quality of Life Questionnaire, Functional Assessment of Cancer Therapy Neurotoxicity scales. Two performance measures assessed function: grip strength (Jamar dynamometer; n = 71) and timed get-up-and-go (TUG; n = 103). Analyses were performed with an overall symptom composite score. Correlations and multiple linear regression analyses were performed to test adverse effects on physical function.Results
The mean age was 64 years (range 45-84), 81% white, 84% on an aromatase inhibitor, and on endocrine therapy for mean 35 months (range 1-130 months). Dominant hand grip strength was inversely correlated with symptom composite scores (r = -0.29, p = .02). Slower TUG was positively correlated with higher Charlson comorbidity level (r = 0.36, p < .001) and higher symptom composite scores (r = 0.24, p = .01). In multivariate analyses, weaker dominant and non-dominant hand grip strength were significantly associated with greater symptom composite scores (β = -0.27, t = 2.43, p = .02 and β = -0.36, t = 3.15, p = .003, respectively) and slower TUG was associated with higher symptom composite scores (β = 0.18, t = 1.97, p = .05).Conclusions
Higher symptom burden is associated with worse physical function, as measured by hand grip strength and TUG. Further study to determine the impact of endocrine therapy and its side effects on function is warranted.Item type: Item , Access status: Open Access , Mobile health messages help sustain recent weight loss.(The American journal of medicine, 2013-11) Shaw, Ryan J; Bosworth, Hayden B; Silva, Susan S; Lipkus, Isaac M; Davis, Linda L; Sha, Ronald S; Johnson, Constance MBackground
Using regulatory focus theory, an intervention of daily weight loss-sustaining messages was developed and tested for acceptability, feasibility, and efficacy on helping people sustain weight loss.Methods
Participants (n = 120) were randomized to a promotion, prevention, or an attention-control text message group after completion of a weight loss program. Participants completed baseline assessments, and reported their weight at 1 and 3 months postbaseline.Results
Participants found the message content and intervention acceptable and valuable. A minimum of one message per day delivered at approximately 8:00 am was deemed the optimal delivery time and frequency. The sustained weight loss rate at month 3 for the control, promotion, and prevention groups was 90%, 95%, and 100%, respectively. Medium-to-large effects were observed for the promotion and prevention groups at month 1 and for prevention at month 3 relative to controls. The mean weight loss for promotion and prevention was 15 pounds, compared with 10 in the controls at month 3.Conclusion
A clinically significant decrease in mean weight, higher rate of sustained weight loss, and medium-to-large effects on sustained weight loss occurred in the promotion and prevention interventions. Tools such as this text message-based intervention that are constructed and guided by evidence-based content and theoretical constructs show promise in helping people sustain healthy behaviors that can lead to improved health outcomes.Item type: Item , Access status: Open Access , The Cardiovascular Intervention Improvement Telemedicine Study (CITIES): rationale for a tailored behavioral and educational pharmacist-administered intervention for achieving cardiovascular disease risk reduction.(Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 2014-02) Zullig, Leah L; Melnyk, S Dee; Stechuchak, Karen M; McCant, Felicia; Danus, Susanne; Oddone, Eugene; Bastian, Lori; Olsen, Maren; Edelman, David; Rakley, Susan; Morey, Miriam; Bosworth, Hayden BBackground
Hypertension, hyperlipidemia, and diabetes are significant, but often preventable, contributors to cardiovascular disease (CVD) risk. Medication and behavioral nonadherence are significant barriers to successful hypertension, hyperlidemia, and diabetes management. Our objective was to describe the theoretical framework underlying a tailored behavioral and educational pharmacist-administered intervention for achieving CVD risk reduction.Materials and methods
Adults with poorly controlled hypertension and/or hyperlipidemia were enrolled from three outpatient primary care clinics associated with the Durham Veterans Affairs Medical Center (Durham, NC). Participants were randomly assigned to receive a pharmacist-administered, tailored, 1-year telephone-based intervention or usual care. The goal of the study was to reduce the risk for CVD through a theory-driven intervention to increase medication adherence and improve health behaviors.Results
Enrollment began in November 2011 and is ongoing. The target sample size is 500 patients.Conclusions
The Cardiovascular Intervention Improvement Telemedicine Study (CITIES) intervention has been designed with a strong theoretical underpinning. The theoretical foundation and intervention are designed to encourage patients with multiple comorbidities and poorly controlled CVD risk factors to engage in home-based monitoring and tailored telephone-based interventions. Evidence suggests that clinical pharmacist-administered telephone-based interventions may be efficiently integrated into primary care for patients with poorly controlled CVD risk factors.Item type: Item , Access status: Open Access , Medication taking behaviors among breast cancer patients on adjuvant endocrine therapy.(Breast (Edinburgh, Scotland), 2015-10) Kimmick, Gretchen; Edmond, Sara N; Bosworth, Hayden B; Peppercorn, Jeffrey; Marcom, Paul K; Blackwell, Kimberly; Keefe, Francis J; Shelby, Rebecca APurpose
To explore how symptoms and psychosocial factors are related to intentional and unintentional non-adherent medication taking behaviors.Methods
Included were postmenopausal women with hormone receptor positive, stage I-IIIA breast cancer, who had completed surgery, chemotherapy, and radiation, and were taking endocrine therapy. Self-administered, standardized measures were completed during a routine clinic visit: Brief Fatigue Inventory, Brief Pain Inventory, Menopause Specific Quality of Life Questionnaire, Functional Assessment of Cancer Therapy General and Neurotoxicity scales, and Self-Efficacy for Appropriate Medication Use Scale. Regression analyses were performed to determine the degree to which demographic, medical, symptom, and psychosocial variables, explain intentional, such as changing one's doses or stopping medication, and unintentional, such as forgetting to take one's medication, non-adherent behaviors.Results
Participants were 112 women: mean age 64 (SD = 9) years; 81% white; mean time from surgery 40 (SD = 28) months; 49% received chemotherapy (39% including a taxane); mean time on endocrine therapy, 35 (SD = 29.6) months; 82% taking an aromatase inhibitor. Intentional and unintentional non-adherent behaviors were described in 33.9% and 58.9% of participants, respectively. Multivariate analysis showed that higher self-efficacy for taking medication was associated with lower levels of unintentional (p = 0.002) and intentional (p = 0.004) non-adherent behaviors. The presence of symptoms (p = 0.03) and lower self-efficacy for physician communication (p = 0.009) were associated with higher levels of intentional non-adherent behaviors.Conclusions
These results suggest that women who report greater symptoms, lower self-efficacy for communicating with their physician, and lower self-efficacy for taking their medication are more likely to engage in both intentional and unintentional non-adherent behaviors.