Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation.
| dc.contributor.author | Sachan, Roger | |
| dc.contributor.author | Jaipan, Panupong | |
| dc.contributor.author | Zhang, Jennifer Y | |
| dc.contributor.author | Degan, Simone | |
| dc.contributor.author | Erdmann, Detlev | |
| dc.contributor.author | Tedesco, Jonathan | |
| dc.contributor.author | Vanderwal, Lyndsi | |
| dc.contributor.author | Stafslien, Shane J | |
| dc.contributor.author | Negut, Irina | |
| dc.contributor.author | Visan, Anita | |
| dc.contributor.author | Dorcioman, Gabriela | |
| dc.contributor.author | Socol, Gabriel | |
| dc.contributor.author | Cristescu, Rodica | |
| dc.contributor.author | Chrisey, Douglas B | |
| dc.contributor.author | Narayan, Roger J | |
| dc.date.accessioned | 2022-09-01T22:06:37Z | |
| dc.date.available | 2022-09-01T22:06:37Z | |
| dc.date.issued | 2017-01 | |
| dc.date.updated | 2022-09-01T22:06:26Z | |
| dc.description.abstract | Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles. | |
| dc.identifier | IJB-3-2-117 | |
| dc.identifier.issn | 2424-7723 | |
| dc.identifier.issn | 2424-8002 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | AccScience Publishing | |
| dc.relation.ispartof | International journal of bioprinting | |
| dc.relation.isversionof | 10.18063/ijb.2017.02.004 | |
| dc.subject | amphotericin B | |
| dc.subject | antifungal | |
| dc.subject | matrix-assisted pulsed laser evaporation | |
| dc.subject | microneedle | |
| dc.title | Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Zhang, Jennifer Y|0000-0002-4485-1750 | |
| pubs.begin-page | 004 | |
| pubs.issue | 2 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Dermatology | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Surgery, Plastic, Maxillofacial, and Oral Surgery | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Regeneration Next Initiative | |
| pubs.publication-status | Published | |
| pubs.volume | 3 |
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