Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk.
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2017-05-23
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Abstract
The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents' self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents' aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology.
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Wang, Frances L, Laurie Chassin, John E Bates, Danielle Dick, Jennifer E Lansford, Gregory S Pettit and Kenneth A Dodge (2017). Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk. Dev Psychopathol. pp. 1–21. 10.1017/S095457941700058X Retrieved from https://hdl.handle.net/10161/15831.
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Jennifer Lansford
Jennifer Lansford is the director of the Center for Child and Family Policy and S. Malcolm Gillis Distinguished Research Professor of Public Policy in the Sanford School of Public Policy.
Dr. Lansford's research focuses on the development of aggression and other behavior problems in youth, with an emphasis on how family and peer contexts contribute to or protect against these outcomes. She examines how experiences with parents (e.g., physical abuse, discipline, divorce) and peers (e.g., rejection, friendships) affect the development of children's behavior problems, how influence operates in adolescent peer groups, and how cultural contexts moderate links between parenting and children's adjustment.
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