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Functional Selectivity at the Dopamine D2 Receptor
The neuromodulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous system functions through diverse signal transduction pathways. D2R is a prominent target for drug treatments in disorders ...
Physiological Functions of Biased Signaling at the Chemokine Receptor CXCR3
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and one of the most common drug targets. It is now well-established that GPCRs can signal through multiple transducers, including ...