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PDLA a potential new potent topical analgesic: a case report.

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Date
2014
Author
Goldberg, Joel S
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Abstract
Polymer D-lactic acid (PDLA) is a hydrogel that has been shown to sequester L-lactate (lactate). This reaction is rapid, spontaneous, and non-enzymatic. Lactate has been shown to have many functions within the nervous system including its use as a secondary fuel to sustain neural activity and as a neuromodulator. In the central nervous system, lactate is produced in glial cells and shuttled to neurons to be used mostly as a fuel. Lactate dehydrogenase (LDH)1 is the predominant LDH isoform within neurons and unlike LDH5, it preferentially converts lactate to pyruvate which can be used to produce adenosine triphosphate (ATP). Considering that lactate is intimately involved in the sustenance of neural activity, PDLA was applied to an open wound and its effects were examined. The results showed that the application of PDLA induced topical analgesia. This may be the first report to demonstrate that sequestering lactate, a source of energy required to sustain the firing of action potentials in neurons, may produce analgesia.
Type
Journal article
Subject
hydrogel
polymer D-lactic acid
topical analgesia
Permalink
https://hdl.handle.net/10161/10219
Published Version (Please cite this version)
10.2147/LRA.S72481
Publication Info
Goldberg, Joel S (2014). PDLA a potential new potent topical analgesic: a case report. Local Reg Anesth, 7. pp. 59-61. 10.2147/LRA.S72481. Retrieved from https://hdl.handle.net/10161/10219.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Joel Steven Goldberg

Adjunct Professor in the Department of Anesthesiology
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