PDLA a potential new potent topical analgesic: a case report.
Abstract
Polymer D-lactic acid (PDLA) is a hydrogel that has been shown to sequester L-lactate
(lactate). This reaction is rapid, spontaneous, and non-enzymatic. Lactate has been
shown to have many functions within the nervous system including its use as a secondary
fuel to sustain neural activity and as a neuromodulator. In the central nervous system,
lactate is produced in glial cells and shuttled to neurons to be used mostly as a
fuel. Lactate dehydrogenase (LDH)1 is the predominant LDH isoform within neurons and
unlike LDH5, it preferentially converts lactate to pyruvate which can be used to produce
adenosine triphosphate (ATP). Considering that lactate is intimately involved in the
sustenance of neural activity, PDLA was applied to an open wound and its effects were
examined. The results showed that the application of PDLA induced topical analgesia.
This may be the first report to demonstrate that sequestering lactate, a source of
energy required to sustain the firing of action potentials in neurons, may produce
analgesia.
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https://hdl.handle.net/10161/10219Published Version (Please cite this version)
10.2147/LRA.S72481Publication Info
Goldberg, Joel S (2014). PDLA a potential new potent topical analgesic: a case report. Local Reg Anesth, 7. pp. 59-61. 10.2147/LRA.S72481. Retrieved from https://hdl.handle.net/10161/10219.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Joel Steven Goldberg
Adjunct Professor in the Department of Anesthesiology

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