Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.
Abstract
The coordinated production of leukocytes in bone marrow is crucial for innate and
adaptive immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis
over lymphopoiesis, a response that supports the reactive neutrophilia that follows
infection. Here we demonstrate that this specialization for granulopoiesis is determined
by inflammation-induced reductions of growth and retention factors, most significantly
stem cell factor and CXCL12, which act preferentially to inhibit lymphoid development.
These hierarchical effects suggest that the normal equilibrium of leukocyte production
in bone marrow is determined by lymphopoiesis' higher demand for specific growth factors
and/or retention signals. Inflammation regulates this balance by reducing growth factors
that have less impact on developing neutrophils than lymphocytes. We demonstrate that
granulopoiesis and lymphopoiesis are coupled specifically in the bone marrow by development
in a common niche and propose that the leukopoietic equilibrium is specified by limiting
amounts of developmental resources.
Type
Journal articleSubject
AnimalsChemokine CXCL12
Chemokines, CXC
Granulocytes
Immunity, Innate
Inflammation
Lymphocytes
Lymphopoiesis
Mice
Myelopoiesis
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https://hdl.handle.net/10161/10906Published Version (Please cite this version)
10.1084/jem.20041419Publication Info
Ueda, Yoshihiro; Kondo, Motonari; & Kelsoe, Garnett (2005). Inflammation and the reciprocal production of granulocytes and lymphocytes in bone
marrow. J Exp Med, 201(11). pp. 1771-1780. 10.1084/jem.20041419. Retrieved from https://hdl.handle.net/10161/10906.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Garnett H. Kelsoe
James B. Duke Distinguished Professor of Immunology
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and
T cell antigen receptor genes. 2. The germinal center reaction and mechanisms for
clonal selection and self - tolerance. The origins of autoimmunity. 3. Interaction
of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses,

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