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Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.

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Date
2015-12
Authors
Saelens, Joseph W
Lau-Bonilla, Dalia
Moller, Anneliese
Medina, Narda
Guzmán, Brenda
Calderón, Maylena
Herrera, Raúl
Sisk, Dana M
Xet-Mull, Ana M
Stout, Jason E
Arathoon, Eduardo
Samayoa, Blanca
Tobin, David M
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(13 total)
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Abstract
Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City.
Type
Journal article
Subject
Beijing strains
Central America
Guatemala
Molecular epidemiology
Tuberculosis
Whole genome sequencing
China
DNA, Bacterial
Databases, Genetic
Disease Outbreaks
Genome, Bacterial
Genotype
Guatemala
Humans
Molecular Epidemiology
Mycobacterium tuberculosis
Phenotype
Phylogeny
Polymorphism, Single Nucleotide
Poverty
Predictive Value of Tests
Sequence Analysis, DNA
Tuberculosis
Urban Health
Permalink
https://hdl.handle.net/10161/11176
Published Version (Please cite this version)
10.1016/j.tube.2015.09.001
Publication Info
Saelens, Joseph W; Lau-Bonilla, Dalia; Moller, Anneliese; Medina, Narda; Guzmán, Brenda; Calderón, Maylena; ... Tobin, David M (2015). Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak. Tuberculosis (Edinb), 95(6). pp. 810-816. 10.1016/j.tube.2015.09.001. Retrieved from https://hdl.handle.net/10161/11176.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Stout

Jason Eric Stout

Professor of Medicine
My research focuses on the epidemiology, natural history, and treatment of tuberculosis and nontuberculous mycobacterial infections. I am also interested in the impact of HIV infection on mycobacterial infection and disease, and in examining health disparities as they relate to infectious diseases, particularly in immigrant populations.
Tobin

David M. Tobin

Associate Professor of Molecular Genetics and Microbiology
Tuberculosis: Mycobacterial Pathogenesis and Host Susceptibility Tuberculosis kills 1.5 million people annually. Our laboratory aims to understand the intricate interplay between mycobacteria and their hosts using a combination of model organism genetics, human genetics, pharmacology and high-resolution microscopy. By identifying key pathways utilized by the infecting bacteria and the host innate immune system, we hope to discover new therapeutic targets and interventi
Alphabetical list of authors with Scholars@Duke profiles.
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