Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.
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The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins with altered abundance during protein kinase A (PKA) activation and repression in the opportunistic human fungal pathogen Cryptococcus neoformans. They observed an association between microbial PKA signaling and ubiquitin-proteasome regulation of protein homeostasis. Additionally, they correlated these processes with expression of polysaccharide capsule on the fungal cell surface, the main virulence-associated phenotype in this organism. Not only are their findings important for microbial pathogenesis, but they also support similar associations between human PKA signaling and ubiquitinated protein accumulation in neurodegenerative diseases.
Cyclic AMP-Dependent Protein Kinases
Gene Expression Regulation, Fungal
Published Version (Please cite this version)10.1128/mBio.00021-16
Publication InfoAlspaugh, J Andrew (2016). Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation. MBio, 7(1). pp. e00021-e00016. 10.1128/mBio.00021-16. Retrieved from https://hdl.handle.net/10161/11677.
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James Andrew Alspaugh II
Professor of Medicine
The focus of my research is to understand the ways in which microorganisms sense and respond to changes in their environment. As microbial pathogens enter the infected host, dramatic genetic and phenotypic events occur that allow these organisms to survive in this harsh environment. We study the model fungal organism Cryptococcus neoformans to define signal transduction pathways associated with systemic fungal diseases. This pathogenic fungus causes lethal infections of the ce
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