Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells.
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Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all TRAs, such as immunoglobulins generated only in B cells after somatic recombination, hyper-mutation, or class-switches. We report here that both mTECs and cortical TECs can efficiently acquire not only cell surface but also intracellular proteins from thymocytes. This reveals a previously unappreciated intercellular sharing of molecules from thymocytes to TECs, which may broaden the TRA inventory in mTECs for establishing a full spectrum of central tolerance.
Major Histocompatibility Complex
Mice, Inbred C57BL
Receptors, Antigen, T-Cell
Published Version (Please cite this version)10.1371/journal.pone.0152641
Publication InfoWang, HX; Qiu, YR; & Zhong, XP (2016). Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. PLoS One, 11(3). pp. e0152641. 10.1371/journal.pone.0152641. Retrieved from http://hdl.handle.net/10161/11812.
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