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The effects of curcumin (diferuloylmethane) on body composition of patients with advanced pancreatic cancer.

dc.contributor.author Parsons, Henrique A
dc.contributor.author Baracos, Vickie E
dc.contributor.author Hong, David S
dc.contributor.author Abbruzzese, James
dc.contributor.author Bruera, Eduardo
dc.contributor.author Kurzrock, Razelle
dc.coverage.spatial United States
dc.date.accessioned 2016-05-01T13:29:06Z
dc.date.issued 2016-04-12
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26934122
dc.identifier 7773
dc.identifier.uri https://hdl.handle.net/10161/11945
dc.description.abstract BACKGROUND: Curcumin is a natural product that is often explored by patients with cancer. Weight loss due to fat and muscle depletion is a hallmark of pancreatic cancer and is associated with worse outcomes. Studies of curcumin's effects on muscularity show conflicting results in animal models. METHODS AND RESULTS: Retrospective matched 1:2 case-control study to evaluate the effects of curcumin on body composition (determined by computerized tomography) of 66 patients with advanced pancreatic cancer (22 treated,44 controls). Average age (SEM) was 63(1.8) years, 30/66(45%) women, median number of prior therapies was 2, median (IQR) time from advanced pancreatic cancer diagnosis to baseline image was 7(2-13.5) months (p>0.2, all variables). All patients lost weight (3.3% and 1.3%, treated vs. control, p=0.13). Treated patients lost more muscle (median [IQR] percent change -4.8[-9.1,-0.1] vs. -0.05%[-4.2, 2.6] in controls,p<0.001) and fat (median [IQR] percent change -6.8%[-15,-0.6] vs. -4.0%[-7.6, 1.3] in controls,p=0.04). Subcutaneous fat was more affected in the treated patients. Sarcopenic patients treated with curcumin(n=15) had survival of 169(115-223) days vs. 299(229-369) sarcopenic controls(p=0.024). No survival difference was found amongst non-sarcopenic patients. CONCLUSIONS: Patients with advanced pancreatic cancer treated with curcumin showed significantly greater loss of subcutaneous fat and muscle than matched untreated controls.
dc.language eng
dc.publisher Impact Journals, LLC
dc.relation.ispartof Oncotarget
dc.relation.isversionof 10.18632/oncotarget.7773
dc.subject body composition
dc.subject curcumin
dc.subject inflammation
dc.subject pancreatic neoplasms
dc.title The effects of curcumin (diferuloylmethane) on body composition of patients with advanced pancreatic cancer.
dc.type Journal article
duke.contributor.id Abbruzzese, James|0634557
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26934122
pubs.begin-page 20293
pubs.end-page 20304
pubs.issue 15
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 7
dc.identifier.eissn 1949-2553


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