Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.
Abstract
A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m
Sestamibi in subjects without previous history of breast cancer using a dedicated
SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging
studies were consented and imaged as part of this IRB-approved breast imaging study.
For each of the seven subjects, one randomly selected breast was imaged prone-pendant
using the dedicated, compact breast SPECT-CT system underneath the shielded patient
support. Iteratively reconstructed and attenuation and/or scatter corrected images
were coregistered; CT images were segmented into glandular and fatty tissue by three
different methods; the average concentration of Sestamibi was determined from the
SPECT data using the CT-based segmentation and previously established quantification
techniques. Very minor differences between the segmentation methods were observed,
and the results indicate an average image-based in vivo Sestamibi concentration of
0.10 ± 0.16 μCi/mL with no preferential uptake by glandular or fatty tissues.
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https://hdl.handle.net/10161/12981Published Version (Please cite this version)
10.1155/2012/146943Publication Info
Mann, Steve D; Perez, Kristy L; McCracken, Emily KE; Shah, Jainil P; Wong, Terence
Z; & Tornai, Martin P (2012). Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue
Type in Healthy Breasts Using Dedicated Breast SPECT-CT. J Oncol, 2012. pp. 146943. 10.1155/2012/146943. Retrieved from https://hdl.handle.net/10161/12981.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Steven Mann
Assistant Professor of Radiology
Martin Paul Tornai
Associate Professor of Radiology
The major research focus of my laboratory concerns high resolution and sensitivity
molecular imaging of normalcy and/or disease in the breast using dedicated molecular
3D imaging techniques. Particular attention is paid to improved patient comfort such
that no breast compression is necessary, which then dictates novel physics and engineering
approaches to obtaining the highest quality data. The term "molecular imaging" means
determining the spatial distribution of biological materials based on t
Terence Z. Wong
Professor of Radiology
1. Anatomic/functional oncologic Imaging: SPECT/CT, PET/CT, novel PET radiotracers
2. Radiotheranostics, Radionuclide therapy of cancer, Radiation Therapy Planning 3.
Imaging biomarkers for guiding treatment strategies 4. Multicenter clinical trial
development (NCI National Clinical Trials Network)
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