Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
Calcium Channel Blockers
Calcium Channels, L-Type
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Cyclic AMP Response Element-Binding Protein
Gene Expression Regulation
Long QT Syndrome
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Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism. Koh, James; Hogue, Joyce A; Wang, Yuli; DiSalvo, Matthew; Allbritton, Nancy L; Shi, Yuhong; Olson, John A; ... (8 authors) (J Cell Mol Med, 2016-02)Primary hyperparathyroidism (PHPT) is a common endocrine neoplastic disorder caused by a failure of calcium sensing secondary to tumour development in one or more of the parathyroid glands. Parathyroid adenomas are comprised ...
Tadross, Michael R; Dick, Ivy E; Yue, David T (Cell, 2008-06-27)Calmodulin (CaM) in complex with Ca(2+) channels constitutes a prototype for Ca(2+) sensors that are intimately colocalized with Ca(2+) sources. The C-lobe of CaM senses local, large Ca(2+) oscillations due to Ca(2+) influx ...
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Xiao, RP; Avdonin, P; Zhou, YY; Cheng, H; Akhter, SA; Eschenhagen, T; Lefkowitz, RJ; ... (9 authors) (Circ Res, 1999-01-08)-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor (betaAR) signal transduction. Although several of these models have altered betaAR subtypes, the specific functional sequelae of betaAR ...