Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
Calcium Channel Blockers
Calcium Channels, L-Type
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Cyclic AMP Response Element-Binding Protein
Gene Expression Regulation
Long QT Syndrome
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Tadross, Michael R; Dick, Ivy E; Yue, David T (Cell, 2008-06-27)Calmodulin (CaM) in complex with Ca(2+) channels constitutes a prototype for Ca(2+) sensors that are intimately colocalized with Ca(2+) sources. The C-lobe of CaM senses local, large Ca(2+) oscillations due to Ca(2+) influx ...
Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism. Koh, James; Hogue, Joyce A; Wang, Yuli; DiSalvo, Matthew; Allbritton, Nancy L; Shi, Yuhong; Olson, John A; ... (8 authors) (J Cell Mol Med, 2016-02)Primary hyperparathyroidism (PHPT) is a common endocrine neoplastic disorder caused by a failure of calcium sensing secondary to tumour development in one or more of the parathyroid glands. Parathyroid adenomas are comprised ...
Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Wang, W; Landstrom, AP; Wang, Q; Munro, ML; Beavers, D; Ackerman, MJ; Soeller, C; ... (8 authors) (American journal of physiology. Heart and circulatory physiology, 2014-11)Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) leak and rapid development of heart failure. The mechanism and physiological ...