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Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature.

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Date
2015
Authors
Theodros, Debebe
Goodwin, C Rory
Crane, Genevieve M
Liauw, Jason
Kleinberg, Lawrence
Lim, Michael
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Abstract
Extrapulmonary small cell carcinomas (EPSCC) are rare malignancies with poor patient prognoses. We present the case of a 63-year-old male who underwent surgical resection of a poorly differentiated small cell carcinoma, likely from a small intestinal primary tumor that metastasized to the cerebellopontine angle (CPA). A 63-year-old male presented with mild left facial paralysis, hearing loss, and balance instability. MRI revealed a 15 mm mass in the left CPA involving the internal auditory canal consistent with a vestibular schwannoma. Preoperative MRI eight weeks later demonstrated marked enlargement to 35 mm. The patient underwent a suboccipital craniectomy and the mass was grossly different visually and in consistency from a standard vestibular schwannoma. The final pathology revealed a poorly differentiated small cell carcinoma. Postoperative PET scan identified avid uptake in the small intestine suggestive of either a small intestinal primary tumor or additional metastatic disease. The patient underwent whole brain radiation therapy and chemotherapy and at last follow-up demonstrated improvement in his symptoms. Surgical resection and radiotherapy are potential treatment options to improve survival in patients diagnosed with NET brain metastases. We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.
Type
Journal article
Permalink
https://hdl.handle.net/10161/15824
Published Version (Please cite this version)
10.1155/2015/847058
Publication Info
Theodros, Debebe; Goodwin, C Rory; Crane, Genevieve M; Liauw, Jason; Kleinberg, Lawrence; & Lim, Michael (2015). Metastatic extrapulmonary small cell carcinoma to the cerebellopontine angle: a case report and review of the literature. Case Rep Oncol Med, 2015. pp. 847058. 10.1155/2015/847058. Retrieved from https://hdl.handle.net/10161/15824.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Goodwin

Courtney Rory Goodwin

Assistant Professor of Neurosurgery
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