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Synthesis of Reconfigurable Flow-Based Biochips for Scalable Single-Cell Screening

dc.contributor.author Ibrahim, Mohamed
dc.contributor.author Sridhar, Aditya
dc.contributor.author Chakrabarty, Krishnendu
dc.contributor.author Schlichtmann, Ulf
dc.date.accessioned 2018-01-11T14:38:52Z
dc.date.available 2018-01-11T14:38:52Z
dc.date.issued 2018-01-11
dc.identifier.uri https://hdl.handle.net/10161/15989
dc.description.abstract Single-cell screening is used to sort a stream of cells into clusters (or types) based on pre-specified biomarkers, thus supporting type-driven biochemical analysis. Reconfigurable flowbased microfluidic biochips (RFBs) can be utilized to screen hundreds of heterogeneous cells within a few minutes, but they are overburdened with the control of a large number of valves. To address this problem, we present a pin-constrained RFB design methodology for single-cell screening. The proposed design is analyzed using computational fluid dynamics simulations, mapped to an RC-lumped model, and combined with intervalve connectivity information to construct a high-level synthesis framework, referred to as Sortex. Simulation results show that Sortex significantly reduces the number of control pins and fulfills the timing requirements of single-cell screening.
dc.language.iso en_US
dc.relation.ispartofseries ECE;2017-03
dc.subject Biochips, depth-first search, design automation, flowbased microfluidics, RC model, timing-aware synthesis
dc.title Synthesis of Reconfigurable Flow-Based Biochips for Scalable Single-Cell Screening
dc.type Report


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