Mapping nonlinear receptive field structure in primate retina at single cone resolution.
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The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals flowing from the input to the output of the primate retina, using a combination of large-scale multi-electrode recordings from an identified ganglion cell type, visual stimulation targeted at individual cone photoreceptors, and a hierarchical computational model. The results reveal nonlinear subunits in the circuity of OFF midget ganglion cells, which subserve high-resolution vision. The model explains light responses to a variety of stimuli more accurately than a linear model, including stimuli targeted to cones within and across subunits. The recovered model components are consistent with known anatomical organization of midget bipolar interneurons. These results reveal the spatial structure of linear and nonlinear encoding, at the resolution of single cells and at the scale of complete circuits.
Retinal Cone Photoreceptor Cells
Neuroanatomical Tract-Tracing Techniques
Published Version (Please cite this version)10.7554/elife.05241
Publication InfoFreeman, Jeremy; Field, Greg D; Li, Peter H; Greschner, Martin; Gunning, Deborah E; Mathieson, Keith; ... Chichilnisky, EJ (2015). Mapping nonlinear receptive field structure in primate retina at single cone resolution. eLife, 4(OCTOBER2015). 10.7554/elife.05241. Retrieved from https://hdl.handle.net/10161/16628.
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Assistant Professor of Neurobiology
My laboratory studies how the retina processes visual scenes and transmits this information to the brain. We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms a