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A three dimensional nerve map of human bladder trigone.

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Date
2017-04
Authors
Purves, J Todd
Spruill, Laura
Rovner, Eric
Borisko, Elyse
McCants, Alden
Mugo, Elizabeth
Wingard, Ainsley
Trusk, Thomas C
Bacro, Thierry
Hughes, Francis M
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Abstract
Central efferent and afferent neural pathways to and from the human urinary bladder are well-characterized, but the location and arborization of these nerves as they traverse the serosa, muscularis, and urothelial layers are not clearly defined. The purpose of this study was to create a three dimensional map of the innervation of the human bladder trigone from the extrinsic perivesical adventitial nerve trunks to the urothelium.A male and a female human bladder were harvested from fresh frozen cadavers and fixed in formalin. The bladder neck and trigone region were serially sectioned (5 μm) and every 20th slide was stained (S100), scanned and aligned to create 3D maps.Nerve penetration into the detrusor muscle occurs with the highest frequency at the bladder neck and interureteric ridge. Nerves traveling parallel to the bladder lumen do so in the adventitia, beyond the outer border of detrusor. In females, the depth of these nerve bands is uniform at 0.7-1.7 cm below the luminal surface, the outer limits of which include the anterior vaginal wall. In the male, depth is more variable owing to detrusor hypertrophy with the minimum depth of nerves approximately 0.5 cm near the interureteric ridge and over 1 cm near the bladder neck.Myelinated neural pathways traversing in the human bladder in the region of the trigone have a discreet regional density. This 3D map of trigonal innervation may provide guidance to more precisely direct therapies for urinary incontinence or pelvic pain. Neurourol. Urodynam. 36:1015-1019, 2017. © 2016 Wiley Periodicals, Inc.
Type
Journal article
Subject
Urothelium
Humans
Cadaver
Imaging, Three-Dimensional
Female
Male
Urinary Bladder
Permalink
https://hdl.handle.net/10161/17173
Published Version (Please cite this version)
10.1002/nau.23049
Publication Info
Purves, J Todd; Spruill, Laura; Rovner, Eric; Borisko, Elyse; McCants, Alden; Mugo, Elizabeth; ... Hughes, Francis M (2017). A three dimensional nerve map of human bladder trigone. Neurourology and urodynamics, 36(4). pp. 1015-1019. 10.1002/nau.23049. Retrieved from https://hdl.handle.net/10161/17173.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Hughes

Monty Hughes Jr.

Assistant Professor in Surgery
 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this l
Purves

J Todd Purves

Associate Professor of Surgery
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