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Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.

dc.contributor.author Greschner, Martin
dc.contributor.author Heitman, Alexander K
dc.contributor.author Field, Greg D
dc.contributor.author Li, Peter H
dc.contributor.author Ahn, Daniel
dc.contributor.author Sher, Alexander
dc.contributor.author Litke, Alan M
dc.contributor.author Chichilnisky, EJ
dc.date.accessioned 2019-01-03T15:41:43Z
dc.date.available 2019-01-03T15:41:43Z
dc.date.issued 2016-08
dc.identifier S0960-9822(16)30548-6
dc.identifier.issn 0960-9822
dc.identifier.issn 1879-0445
dc.identifier.uri https://hdl.handle.net/10161/17868
dc.description.abstract Understanding the function of modulatory interneuron networks is a major challenge, because such networks typically operate over long spatial scales and involve many neurons of different types. Here, we use an indirect electrical imaging method to reveal the function of a spatially extended, recurrent retinal circuit composed of two cell types. This recurrent circuit produces peripheral response suppression of early visual signals in the primate magnocellular visual pathway. We identify a type of polyaxonal amacrine cell physiologically via its distinctive electrical signature, revealed by electrical coupling with ON parasol retinal ganglion cells recorded using a large-scale multi-electrode array. Coupling causes the amacrine cells to fire spikes that propagate radially over long distances, producing GABA-ergic inhibition of other ON parasol cells recorded near the amacrine cell axonal projections. We propose and test a model for the function of this amacrine cell type, in which the extra-classical receptive field of ON parasol cells is formed by reciprocal inhibition from other ON parasol cells in the periphery, via the electrically coupled amacrine cell network.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Current biology : CB
dc.relation.isversionof 10.1016/j.cub.2016.05.051
dc.subject Visual Pathways
dc.subject Interneurons
dc.subject Amacrine Cells
dc.subject Retina
dc.subject Animals
dc.subject Macaca fascicularis
dc.subject Macaca mulatta
dc.subject Electrophysiological Phenomena
dc.title Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.
dc.type Journal article
duke.contributor.id Field, Greg D|0663656
dc.date.updated 2019-01-03T15:41:41Z
pubs.begin-page 1935
pubs.end-page 1942
pubs.issue 15
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published
pubs.volume 26


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