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Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells.

dc.contributor.author Field, Greg
dc.contributor.author Yao, Xiaoyang
dc.contributor.author Cafaro, Jon
dc.contributor.author McLaughlin, Amanda J
dc.contributor.author Postma, Friso R
dc.contributor.author Paul, David L
dc.contributor.author Awatramani, Gautam
dc.date.accessioned 2019-01-03T15:43:07Z
dc.date.available 2019-01-03T15:43:07Z
dc.date.issued 2018-10
dc.identifier S0896-6273(18)30724-4
dc.identifier.issn 0896-6273
dc.identifier.issn 1097-4199
dc.identifier.uri https://hdl.handle.net/10161/17870
dc.description.abstract Direction-selective ganglion cells (DSGCs) deliver signals from the retina to multiple brain areas to indicate the presence and direction of motion. Delivering reliable signals in response to motion is critical across light levels. Here we determine how populations of DSGCs adapt to changes in light level, from moonlight to daylight. Using large-scale measurements of neural activity, we demonstrate that the population of DSGCs switches encoding strategies across light levels. Specifically, the direction tuning of superior (upward)-preferring ON-OFF DSGCs becomes broader at low light levels, whereas other DSGCs exhibit stable tuning. Using a conditional knockout of gap junctions, we show that this differential adaptation among superior-preferring ON-OFF DSGCs is caused by connexin36-mediated electrical coupling and differences in effective GABAergic inhibition. Furthermore, this adaptation strategy is beneficial for balancing motion detection and direction estimation at the lower signal-to-noise ratio encountered at night. These results provide insights into how light adaptation impacts motion encoding in the retina.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Neuron
dc.relation.isversionof 10.1016/j.neuron.2018.08.021
dc.subject Connexin-36
dc.subject cell types
dc.subject classification
dc.subject detection sensitivity
dc.subject direction discrimination
dc.subject multielectrode arrays
dc.subject neural coding
dc.subject population codes
dc.title Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells.
dc.type Journal article
dc.date.updated 2019-01-03T15:43:05Z
pubs.begin-page 216
pubs.end-page 228.e6
pubs.issue 1
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published
pubs.volume 100


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