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    Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.

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    Date
    2018-06
    Authors
    Troy, Jesse
    Lee, Walter
    Liu, Zhensheng
    Wei, Qingyi
    Han, Peng
    Liu, Hongliang
    Shi, Qiong
    Zevallos, Jose P
    Li, Guojun
    Sturgis, Erich M
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    Abstract
    Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients and 295 cancer-free controls, we investigated whether expression levels of eight core NER proteins were associated with risk of SCCHN. We quantified NER protein expression levels in cultured peripheral lymphocytes using a reverse-phase protein microarray. Compared with the controls, SCCHN patients had statistically significantly lower expression levels of ERCC3 and XPA (P = 0.001 and 0.001, respectively). After dividing the subjects by controls' median values of expression levels, we found a dose-dependent association between an increased risk of SCCHN and low expression levels of ERCC3 (adjusted OR, 1.75, and 95% CI: 1.26-2.42; Ptrend  = 0.008) and XPA (adjusted OR, 1.88; 95% CI, 1.35-2.60; Ptrend  = 0.001). We also identified a significant multiplicative interaction between smoking status and ERCC3 expression levels (P = 0.014). Finally, after integrating demographic and clinical variables, we found that the addition of ERCC3 and XPA expression levels to the model significantly improved the sensitivity of the expanded model on SCCHN risk. In conclusion, reduced protein expression levels of ERCC3 and XPA were associated with an increased risk of SCCHN. However, these results need to be confirmed in additional large studies.
    Type
    Journal article
    Subject
    Lymphocytes
    Cells, Cultured
    Humans
    Carcinoma, Squamous Cell
    Head and Neck Neoplasms
    DNA Helicases
    DNA-Binding Proteins
    Risk Assessment
    Risk Factors
    Adult
    Aged
    Aged, 80 and over
    Middle Aged
    Female
    Male
    Xeroderma Pigmentosum Group A Protein
    Young Adult
    Permalink
    https://hdl.handle.net/10161/18510
    Published Version (Please cite this version)
    10.1002/mc.22801
    Publication Info
    Troy, Jesse; Lee, Walter; Liu, Zhensheng; Wei, Qingyi; Han, Peng; Liu, Hongliang; ... Sturgis, Erich M (2018). Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Molecular carcinogenesis, 57(6). pp. 784-793. 10.1002/mc.22801. Retrieved from https://hdl.handle.net/10161/18510.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Lee

    Walter T Lee

    Associate Professor of Surgery
    Global Health, Virtue-Based Professional Development and Leadership, Device Development for Cancer Detection

    Zhensheng Liu

    Assistant Professor of Medicine
    Troy

    Jesse David Troy

    Assistant Professor of Pediatrics
    I am a medical statistician who provides statistical support for research studies in stem cell transplantation and cell therapies for a variety of indications including cerebral palsy (CP), brain injury, autism, cancer, and stroke.  My personal research interests are related to medical decision making and patient-centered outcomes in hematologic malignancies. I currently serve as the Scientific Director of the Data Coordinating Center for the National MDS Study (http://www.thenation
    Wei

    Qingyi Wei

    Professor in Population Health Sciences
    Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
    Alphabetical list of authors with Scholars@Duke profiles.
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