Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.
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Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients and 295 cancer-free controls, we investigated whether expression levels of eight core NER proteins were associated with risk of SCCHN. We quantified NER protein expression levels in cultured peripheral lymphocytes using a reverse-phase protein microarray. Compared with the controls, SCCHN patients had statistically significantly lower expression levels of ERCC3 and XPA (P = 0.001 and 0.001, respectively). After dividing the subjects by controls' median values of expression levels, we found a dose-dependent association between an increased risk of SCCHN and low expression levels of ERCC3 (adjusted OR, 1.75, and 95% CI: 1.26-2.42; Ptrend = 0.008) and XPA (adjusted OR, 1.88; 95% CI, 1.35-2.60; Ptrend = 0.001). We also identified a significant multiplicative interaction between smoking status and ERCC3 expression levels (P = 0.014). Finally, after integrating demographic and clinical variables, we found that the addition of ERCC3 and XPA expression levels to the model significantly improved the sensitivity of the expanded model on SCCHN risk. In conclusion, reduced protein expression levels of ERCC3 and XPA were associated with an increased risk of SCCHN. However, these results need to be confirmed in additional large studies.
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Aged, 80 and over
Xeroderma Pigmentosum Group A Protein
Published Version (Please cite this version)10.1002/mc.22801
Publication InfoTroy, Jesse; Lee, Walter; Liu, Zhensheng; Wei, Qingyi; Han, Peng; Liu, Hongliang; ... Sturgis, Erich M (2018). Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Molecular carcinogenesis, 57(6). pp. 784-793. 10.1002/mc.22801. Retrieved from https://hdl.handle.net/10161/18510.
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Associate Professor of Surgery
Global Health, Virtue-Based Professional Development and Leadership, Device Development for Cancer Detection
Assistant Professor of Medicine
Assistant Professor of Pediatrics
I am a medical statistician who provides statistical support for research studies in stem cell transplantation and cell therapies for a variety of indications including cerebral palsy (CP), brain injury, autism, cancer, and stroke. My personal research interests are related to medical decision making and patient-centered outcomes in hematologic malignancies. I currently serve as the Scientific Director of the Data Coordinating Center for the National MDS Study (http://www.thenation
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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