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Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.

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Date
2018-06
Authors
Han, Peng
Liu, Hongliang
Shi, Qiong
Liu, Zhensheng
Troy, Jesse D
Lee, Walter T
Zevallos, Jose P
Li, Guojun
Sturgis, Erich M
Wei, Qingyi
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Abstract
Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients and 295 cancer-free controls, we investigated whether expression levels of eight core NER proteins were associated with risk of SCCHN. We quantified NER protein expression levels in cultured peripheral lymphocytes using a reverse-phase protein microarray. Compared with the controls, SCCHN patients had statistically significantly lower expression levels of ERCC3 and XPA (P = 0.001 and 0.001, respectively). After dividing the subjects by controls' median values of expression levels, we found a dose-dependent association between an increased risk of SCCHN and low expression levels of ERCC3 (adjusted OR, 1.75, and 95% CI: 1.26-2.42; Ptrend  = 0.008) and XPA (adjusted OR, 1.88; 95% CI, 1.35-2.60; Ptrend  = 0.001). We also identified a significant multiplicative interaction between smoking status and ERCC3 expression levels (P = 0.014). Finally, after integrating demographic and clinical variables, we found that the addition of ERCC3 and XPA expression levels to the model significantly improved the sensitivity of the expanded model on SCCHN risk. In conclusion, reduced protein expression levels of ERCC3 and XPA were associated with an increased risk of SCCHN. However, these results need to be confirmed in additional large studies.
Type
Journal article
Subject
Lymphocytes
Cells, Cultured
Humans
Carcinoma, Squamous Cell
Head and Neck Neoplasms
DNA Helicases
DNA-Binding Proteins
Risk Assessment
Risk Factors
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Xeroderma Pigmentosum Group A Protein
Young Adult
Permalink
https://hdl.handle.net/10161/18510
Published Version (Please cite this version)
10.1002/mc.22801
Publication Info
Han, Peng; Liu, Hongliang; Shi, Qiong; Liu, Zhensheng; Troy, Jesse D; Lee, Walter T; ... Wei, Qingyi (2018). Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. Molecular carcinogenesis, 57(6). pp. 784-793. 10.1002/mc.22801. Retrieved from https://hdl.handle.net/10161/18510.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Lee

Walter T Lee

Professor of Head and Neck Surgery & Communication Sciences
Global Health, Virtue-Based Professional Development and Leadership, Device Development for Cancer Detection

Zhensheng Liu

Assistant Professor of Medicine
Troy

Jesse David Troy

Assistant Professor of Biostatistics & Bioinformatics
I am a biostatistician supporting research in cell therapies and regenerative medicine at the Duke Marcus Center for Cellular Cures, and research studies in cancer therapeutics and palliative care at the Duke Cancer Institute. I also teach biostatistics in the Master of Biostatistics program and the <a href="
Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
Alphabetical list of authors with Scholars@Duke profiles.
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