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Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.

dc.contributor.author Swamy, Geeta
dc.contributor.author Grotegut, Chad
dc.contributor.author Hughes, Brenna
dc.contributor.author Weber, Jeremy
dc.contributor.author Harris, Benjamin S
dc.contributor.author Hopkins, Maeve K
dc.contributor.author Villers, Margaret S
dc.contributor.author Pieper, Carl
dc.contributor.author Heine, R Phillips
dc.date.accessioned 2019-06-21T12:01:34Z
dc.date.available 2019-06-21T12:01:34Z
dc.date.issued 2019-04-30
dc.identifier 190014
dc.identifier.issn 2157-6998
dc.identifier.issn 2157-7005
dc.identifier.uri https://hdl.handle.net/10161/18965
dc.description.abstract Objective  To examine the association between perioperative Beta ( β ))-lactam versus non- β -lactam antibiotics and cesarean delivery surgical site infection (SSI). Study Design  Retrospective cohort of women undergoing cesarean delivery from January 1 to December 31, 2014. All women undergoing cesarean after 34 weeks with a postpartum visit were included. Prevalence of SSI was compared between women receiving β -lactam versus non- β -lactam antibiotics. Bivariate analyses were performed using Pearson's Chi-square, Fisher's exact, or Wilcoxon's rank-sum tests. Logistic regression models were fit controlling for possible confounders. Results  Of the 929 women included, 826 (89%) received β -lactam prophylaxis and 103 (11%) received a non- β -lactam. Among the 893 women who reported a non-type I (low risk) allergy, 819 (92%) received β -lactam prophylaxis. SSI occurred in 7% of women who received β -lactam antibiotics versus 15% of women who received a non- β -lactam ( p  = 0.004). β -Lactam prophylaxis was associated with lower odds of SSI compared with non- β -lactam antibiotics (odds ratio [OR] = 0.43; 95% confidence interval [CI] = 0.22-0.83; p  = 0.01) after controlling for chorioamnionitis in labor, postlabor cesarean, endometritis, tobacco use, and body mass index (BMI). Conclusion   β -Lactam perioperative prophylaxis is associated with lower odds of a cesarean delivery surgical site infection compared with non- β -lactam antibiotics.
dc.language eng
dc.publisher Georg Thieme Verlag KG
dc.relation.ispartof AJP reports
dc.relation.isversionof 10.1055/s-0039-1685503
dc.subject antibiotics
dc.subject cesarean delivery
dc.subject penicillin allergy
dc.subject surgical site infection
dc.title Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.
dc.type Journal article
duke.contributor.id Swamy, Geeta|0282189
duke.contributor.id Grotegut, Chad|0225009
duke.contributor.id Hughes, Brenna|0724464
duke.contributor.id Weber, Jeremy|0716457
dc.date.updated 2019-06-21T12:01:32Z
pubs.begin-page e167
pubs.end-page e171
pubs.issue 2
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Staff
pubs.organisational-group Biostatistics & Bioinformatics
pubs.organisational-group Basic Science Departments
pubs.publication-status Published
pubs.volume 9
duke.contributor.orcid Swamy, Geeta|0000-0001-5092-6993


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