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Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila.

dc.contributor.author Yang, Rebecca
dc.contributor.author Wu, Shun-Fan
dc.contributor.author Ja, Ya-Long
dc.contributor.author Zhang, Yi-Jie
dc.date.accessioned 2019-07-01T13:24:37Z
dc.date.available 2019-07-01T13:24:37Z
dc.date.issued 2019-06-11
dc.identifier 46165
dc.identifier.issn 2050-084X
dc.identifier.issn 2050-084X
dc.identifier.uri https://hdl.handle.net/10161/19048
dc.description.abstract Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca2+ influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions.
dc.language eng
dc.publisher eLife Sciences Publications, Ltd
dc.relation.ispartof eLife
dc.relation.isversionof 10.7554/eLife.46165
dc.subject D. melanogaster
dc.subject Drosophila
dc.subject TMC neurons
dc.subject egg-laying
dc.subject hardness discrimination
dc.subject neuroscience
dc.subject sensory integration
dc.subject sweet taste neurons
dc.title Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila.
dc.type Journal article
dc.date.updated 2019-07-01T13:24:35Z
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.publication-status Published
pubs.volume 8


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